{"id":"https://openalex.org/W1997368488","doi":"https://doi.org/10.1089/neu.2009.0895","title":"Impact of Early Administration of Sertraline on Depressive Symptoms in the First Year after Traumatic Brain Injury","display_name":"Impact of Early Administration of Sertraline on Depressive Symptoms in the First Year after Traumatic Brain Injury","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W1997368488","doi":"https://doi.org/10.1089/neu.2009.0895","mag":"1997368488","pmid":"https://pubmed.ncbi.nlm.nih.gov/19929217"},"language":"en","primary_location":{"id":"doi:10.1089/neu.2009.0895","doi":"https://doi.org/10.1089/neu.2009.0895","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2009.0895","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038244749","display_name":"Thomas A. Novack","orcid":"https://orcid.org/0000-0003-3043-7900","observed_orcids":["https://orcid.org/0000-0003-3043-7900"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas A. Novack","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama","Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35249-7330, USA. Novack@uab.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35249-7330, USA. Novack@uab.edu","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103395813","display_name":"James H. Ba\u00f1os","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Ba\u00f1os","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043434561","display_name":"Robert C. Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Brunner","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027217533","display_name":"Sharon Guin-Renfroe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Renfroe","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022605090","display_name":"Jay Merlin Meythaler","orcid":"https://orcid.org/0000-0002-4078-2436","observed_orcids":["https://orcid.org/0000-0002-4078-2436"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay M. Meythaler","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Wayne State University, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038244749"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":1.7907,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.85170464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"11","first_page":"1921","last_page":"1928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9800000190734863},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9909999966621399},{"id":"https://openalex.org/keywords/post-traumatic-depression","display_name":"post-traumatic depression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.8109999895095825},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neurobehavioral-functioning","display_name":"neurobehavioral function","score":0.6990000009536743},{"id":"https://openalex.org/keywords/depression-prevention","display_name":"depression prevention","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.9579627513885498},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7441160678863525},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6517933011054993},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5032088160514832},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4848405122756958},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.469168484210968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46440884470939636},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4598596394062042},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4561426639556885},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.42999354004859924},{"id":"https://openalex.org/C2781210005","wikidata":"https://www.wikidata.org/wiki/Q6738337","display_name":"Major depressive episode","level":3,"score":0.426474392414093},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.41717129945755005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37689611315727234},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.20515137910842896},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12110486626625061},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020280","descriptor_name":"Sertraline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/neu.2009.0895","doi":"https://doi.org/10.1089/neu.2009.0895","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2009.0895","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:19929217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19929217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337112","display_name":"National Institute on Disability and Rehabilitation Research","ror":"https://ror.org/021adze67"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W2742689","https://openalex.org/W24345798","https://openalex.org/W388660883","https://openalex.org/W1815011115","https://openalex.org/W1896642986","https://openalex.org/W1966161647","https://openalex.org/W1969874465","https://openalex.org/W1977081702","https://openalex.org/W1992959445","https://openalex.org/W1994214743","https://openalex.org/W1995485985","https://openalex.org/W2000870178","https://openalex.org/W2014737049","https://openalex.org/W2018311752","https://openalex.org/W2036454650","https://openalex.org/W2039215581","https://openalex.org/W2039903541","https://openalex.org/W2040636349","https://openalex.org/W2049328151","https://openalex.org/W2055332375","https://openalex.org/W2070285161","https://openalex.org/W2072358421","https://openalex.org/W2073687865","https://openalex.org/W2076992585","https://openalex.org/W2079765477","https://openalex.org/W2080754325","https://openalex.org/W2080791253","https://openalex.org/W2088939763","https://openalex.org/W2097235661","https://openalex.org/W2100549080","https://openalex.org/W2102772209","https://openalex.org/W2103519615","https://openalex.org/W2111474478","https://openalex.org/W2112778345","https://openalex.org/W2119618076","https://openalex.org/W2129579709","https://openalex.org/W2130613639","https://openalex.org/W2132322340","https://openalex.org/W2135916631","https://openalex.org/W2146599657","https://openalex.org/W2147282051","https://openalex.org/W2151851534","https://openalex.org/W2157449959","https://openalex.org/W2159290299","https://openalex.org/W2164346310","https://openalex.org/W2166010688","https://openalex.org/W2167634014","https://openalex.org/W4299355172"],"related_works":["https://openalex.org/W2083029100","https://openalex.org/W2076976936","https://openalex.org/W1978420745","https://openalex.org/W2954914492","https://openalex.org/W2616694829","https://openalex.org/W2765792238","https://openalex.org/W2146599657","https://openalex.org/W3033220198","https://openalex.org/W4230496386","https://openalex.org/W2559101123"],"abstract_inverted_index":{"The":[0],"potential":[1],"for":[2,65],"sertraline":[3,60,116,144,220,241],"administered":[4,221],"in":[5,24,32,154,170,197,223],"the":[6,20,25,73,82,89,93,118,139,143,158,161,164,181,187,192,200,206,237],"first":[7,26,119],"3":[8,66,120],"months":[9,121],"after":[10,28,46,122,205,225,240],"moderate":[11],"to":[12,18,217],"severe":[13],"traumatic":[14],"brain":[15],"injury":[16,29,47,123],"(TBI)":[17],"decrease":[19],"incidence":[21],"of":[22,43,55,75,92,128,134,142,160,202],"depression":[23],"year":[27,162],"was":[30,79,150],"assessed":[31,80],"a":[33,132],"double-blinded":[34],"randomized":[35],"control":[36],"trial.":[37],"Subjects":[38,68],"were":[39,69],"enrolled":[40],"an":[41],"average":[42],"21":[44],"days":[45],"(none":[48],">8":[49],"weeks)":[50],"followed":[51],"by":[52],"oral":[53],"administration":[54,195],"placebo":[56,107,129],"(50":[57],"subjects)":[58,64],"or":[59,136],"50":[61],"mg":[62],"(49":[63],"months.":[67],"not":[70,177,190],"depressed":[71,179],"at":[72],"time":[74],"study":[76,216],"initiation.":[77],"Outcome":[78],"using":[81],"Hamilton":[83],"Depression":[84,90],"Rating":[85],"Scale":[86,91],"(HDRS)":[87],"and":[88,101],"Neurobehavioral":[94],"Functioning":[95],"Inventory":[96],"(NFI).":[97],"Based":[98],"on":[99,138,236],"intent-to-treat":[100],"efficacy":[102],"subset":[103],"analyses,":[104],"those":[105,114,176],"receiving":[106,115,125],"exhibited":[108],"significantly":[109],"greater":[110,137],"depressive":[111,155,172,203],"symptoms":[112,156,173,204],"than":[113],"during":[117,157],"while":[124,180],"placebo/drug":[126],"(10%":[127],"group":[130],"achieving":[131],"score":[133],"6":[135],"HDRS,":[140],"0%":[141],"group;":[145],"p":[146],"<":[147],"0.023.).":[148],"There":[149,210],"no":[151,212],"significant":[152],"difference":[153],"remainder":[159],"between":[163],"two":[165],"groups.":[166],"Sertraline":[167],"is":[168,183,208,211,230,242],"effective":[169],"diminishing":[171],"even":[174],"among":[175],"clinically":[178],"medication":[182],"being":[184],"taken.":[185],"However,":[186],"results":[188],"do":[189],"support":[191],"idea":[193],"that":[194,219],"early":[196,222],"recovery":[198,224],"diminishes":[199],"expression":[201],"drug":[207],"stopped.":[209],"basis":[213],"from":[214],"this":[215],"assume":[218],"TBI,":[226],"when":[227],"neurotransmitter":[228],"functioning":[229],"often":[231],"altered,":[232],"has":[233],"ongoing":[234],"effects":[235],"serotonin":[238],"system":[239],"discontinued.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}