{"id":"https://openalex.org/W1997326200","doi":"https://doi.org/10.1016/0304-3940(96)12706-3","title":"Interleukin (IL)-1\u03b2, IL-2, IL-4, IL-6 and transforming growth factor-\u03b1 levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease","display_name":"Interleukin (IL)-1\u03b2, IL-2, IL-4, IL-6 and transforming growth factor-\u03b1 levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1997326200","doi":"https://doi.org/10.1016/0304-3940(96)12706-3","mag":"1997326200","pmid":"https://pubmed.ncbi.nlm.nih.gov/8809836"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3940(96)12706-3","doi":"https://doi.org/10.1016/0304-3940(96)12706-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3940(96)12706-3","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081862693","display_name":"Makio Mogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makio Mogi","raw_affiliation_strings":["Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082446279","display_name":"Minoru Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Harada","raw_affiliation_strings":["Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029484704","display_name":"Hirotaro Narabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaro Narabayashi","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110784518","display_name":"Hirofumi Inagaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Inagaki","raw_affiliation_strings":["Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109161620","display_name":"Masayasu Minami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayasu Minami","raw_affiliation_strings":["Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004939550","display_name":"Toshiharu Nagatsu","orcid":"https://orcid.org/0000-0002-9216-6029","observed_orcids":["https://orcid.org/0000-0002-9216-6029"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4405287432","display_name":"Center for Medical Science, Fujita Health University","ror":"https://ror.org/054he0258","country_code":"JP","type":"facility","lineage":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiharu Nagatsu","raw_affiliation_strings":["Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004939550"],"corresponding_institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":3.9014,"has_fulltext":false,"cited_by_count":561,"citation_normalized_percentile":{"value":0.93603928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"211","issue":"1","first_page":"13","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ventricular-cerebrospinal-fluid","display_name":"ventricular cerebrospinal fluid","score":0.9649999737739563},{"id":"https://openalex.org/keywords/juvenile-parkinsonism","display_name":"juvenile parkinsonism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.6759999990463257},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6887882351875305},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5894511938095093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5684579014778137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5617436170578003},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.545815110206604},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5383326411247253},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.522894561290741},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5097617506980896},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.49401694536209106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49232590198516846},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.44981271028518677},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4398808181285858},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.34764590859413147},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1322804093360901},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002552","descriptor_name":"Cerebral Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002552","descriptor_name":"Cerebral Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3940(96)12706-3","doi":"https://doi.org/10.1016/0304-3940(96)12706-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3940(96)12706-3","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:8809836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8809836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1479685586","https://openalex.org/W1784841343","https://openalex.org/W1894641937","https://openalex.org/W1966918485","https://openalex.org/W1977255656","https://openalex.org/W1980069116","https://openalex.org/W1982438527","https://openalex.org/W1982932097","https://openalex.org/W1984218330","https://openalex.org/W1984292807","https://openalex.org/W1989530031","https://openalex.org/W2022355606","https://openalex.org/W2024377399","https://openalex.org/W2025478725","https://openalex.org/W2027724538","https://openalex.org/W2045756832","https://openalex.org/W2050329524","https://openalex.org/W2059977837","https://openalex.org/W2072100716","https://openalex.org/W2082861241","https://openalex.org/W2118582599","https://openalex.org/W2122400789","https://openalex.org/W2127145932","https://openalex.org/W2128635872","https://openalex.org/W2135392289","https://openalex.org/W2137829901","https://openalex.org/W2405547986","https://openalex.org/W2416725921","https://openalex.org/W2416885298","https://openalex.org/W2417399610","https://openalex.org/W2436560949","https://openalex.org/W2468924547","https://openalex.org/W2481371503","https://openalex.org/W4237550394","https://openalex.org/W4248392232","https://openalex.org/W6713708444","https://openalex.org/W6844504792"],"related_works":["https://openalex.org/W1966918485","https://openalex.org/W1977553663","https://openalex.org/W2497326071","https://openalex.org/W3009059975","https://openalex.org/W2049733399","https://openalex.org/W2127697359","https://openalex.org/W2082861241","https://openalex.org/W17149418","https://openalex.org/W2104183725","https://openalex.org/W2039631987"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}