{"id":"https://openalex.org/W1997306650","doi":"https://doi.org/10.1097/00000539-199806000-00022","title":"Analgesic and Cognitive Effects of Intravenous Ketamine-Alfentanil Combinations Versus Either Drug Alone After Intradermal Capsaicin in Normal Subjects","display_name":"Analgesic and Cognitive Effects of Intravenous Ketamine-Alfentanil Combinations Versus Either Drug Alone After Intradermal Capsaicin in Normal Subjects","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1997306650","doi":"https://doi.org/10.1097/00000539-199806000-00022","mag":"1997306650","pmid":"https://pubmed.ncbi.nlm.nih.gov/9620514"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-199806000-00022","doi":"https://doi.org/10.1097/00000539-199806000-00022","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199806000-00022","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008769882","display_name":"Navil F. Sethna","orcid":"https://orcid.org/0000-0003-2200-9826","observed_orcids":["https://orcid.org/0000-0003-2200-9826"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navil F. Sethna","raw_affiliation_strings":["Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892-1258, USA","(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892-1258, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026872421","display_name":"Maywin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maywin Liu","raw_affiliation_strings":["(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070468727","display_name":"Richard H. Gracely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gracely","raw_affiliation_strings":["(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113844276","display_name":"Gary J. Bennett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary J. Bennett","raw_affiliation_strings":["(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111628764","display_name":"Mitchell B. Max","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell B. Max","raw_affiliation_strings":["(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Liu) Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"(Sethna) Department of Anesthesia, Harvard Medical School, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(Sethna, Liu, Gracely, Bennett, Max) Pain and Neurosensory Mechanisms Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5111628764"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":2.7725,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.90275147,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"86","issue":"6","first_page":"1250","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.24459999799728394,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.15530000627040863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alfentanil","display_name":"alfentanil","score":1.0},{"id":"https://openalex.org/keywords/capsaicin-induced-pain","display_name":"capsaicin-induced pain","score":0.8479999899864197},{"id":"https://openalex.org/keywords/experimental-pain","display_name":"experimental pain","score":0.5809999704360962},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.765999972820282},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8650000095367432},{"id":"https://openalex.org/keywords/digit-symbol-substitution-test","display_name":"Digit Symbol Substitution Test","score":0.7319999933242798},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.5440000295639038},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9481151103973389},{"id":"https://openalex.org/C2781091344","wikidata":"https://www.wikidata.org/wiki/Q176533","display_name":"Alfentanil","level":3,"score":0.9424057006835938},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.7498341202735901},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6960670948028564},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.653052806854248},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.650059700012207},{"id":"https://openalex.org/C2778937273","wikidata":"https://www.wikidata.org/wiki/Q10302254","display_name":"Intradermal injection","level":2,"score":0.48626482486724854},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4482668340206146},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4300103783607483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42291632294654846},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.1715332269668579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09735730290412903},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000778","descriptor_name":"Anesthetics, Dissociative","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000778","descriptor_name":"Anesthetics, Dissociative","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015760","descriptor_name":"Alfentanil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015760","descriptor_name":"Alfentanil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000539-199806000-00022","doi":"https://doi.org/10.1097/00000539-199806000-00022","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-199806000-00022","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"doi:10.1213/00000539-199806000-00022","doi":"https://doi.org/10.1213/00000539-199806000-00022","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199806000-00022","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:9620514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9620514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W27717426","https://openalex.org/W80356008","https://openalex.org/W1535033967","https://openalex.org/W1906520502","https://openalex.org/W1973133262","https://openalex.org/W1981707931","https://openalex.org/W1989958459","https://openalex.org/W2000808619","https://openalex.org/W2006858522","https://openalex.org/W2007174401","https://openalex.org/W2009672632","https://openalex.org/W2011894583","https://openalex.org/W2015621856","https://openalex.org/W2025951798","https://openalex.org/W2044964613","https://openalex.org/W2050988241","https://openalex.org/W2055666787","https://openalex.org/W2055960847","https://openalex.org/W2057650108","https://openalex.org/W2068596852","https://openalex.org/W2079312738","https://openalex.org/W2083900705","https://openalex.org/W2084688496","https://openalex.org/W2089183587","https://openalex.org/W2112733934","https://openalex.org/W2325182562","https://openalex.org/W2430295200","https://openalex.org/W4301513925","https://openalex.org/W4407751074"],"related_works":["https://openalex.org/W2057650108","https://openalex.org/W2009672632","https://openalex.org/W2025235669","https://openalex.org/W2317209152","https://openalex.org/W2021399290","https://openalex.org/W80356008","https://openalex.org/W2091751728","https://openalex.org/W2049046179","https://openalex.org/W1621992602","https://openalex.org/W1997635132"],"abstract_inverted_index":{"UNLABELLED:":[0],"Combinations":[1],"of":[2,32,35,39,51,65,120,146,174,181,193,213,220],"opioids":[3],"and":[4,11,44,54,100,118,124,133,148,154,209],"N-methyl-D-aspartate":[5,199],"(NMDA)":[6],"antagonists":[7],"enhance":[8],"acute":[9],"antinociception":[10],"reduce":[12],"opioid":[13,195],"tolerance":[14],"in":[15,25,41,57,73,162,224],"some":[16],"animal":[17],"experiments":[18],"but":[19],"have":[20],"received":[21],"little":[22],"rigorous":[23],"study":[24,79],"humans.":[26],"To":[27],"quantitatively":[28],"assess":[29],"the":[30,33,128,134,144,214],"nature":[31],"interaction":[34],"these":[36],"two":[37],"classes":[38],"drugs":[40],"producing":[42],"analgesia":[43],"cognitive":[45,125,155],"impairment,":[46],"we":[47,190],"compared":[48],"i.v.":[49],"infusions":[50],"ketamine,":[52],"alfentanil,":[53],"ketamine-alfentanil":[55,176],"combinations":[56],"12":[58],"normal":[59,207],"volunteers":[60,208],"after":[61],"an":[62,194,198],"intradermal":[63],"injection":[64],"capsaicin.":[66],"Drug":[67],"doses":[68,180,192],"for":[69,143],"a":[70,175,186,217],"70-kg":[71],"subject":[72],"this":[74,163],"six-session,":[75],"randomized,":[76],"double-blind,":[77,187],"cross-over":[78],"were:":[80],"ketamine":[81,84,93,101,147],"20":[82],"mg,":[83,86,89,92,99,107],"5":[85],"alfentanil":[87,90,97,105,149],"2":[88],"0.5":[91],"10":[94],"mg":[95,103],"+":[96,104],"1":[98],"2.5":[102],"0.25":[106],"given":[108],"over":[109,178,216],"35":[110],"min.":[111],"Outcome":[112],"measures":[113],"were":[114],"background":[115],"pain,":[116,151],"area":[117],"magnitude":[119],"hyperalgesia":[121],"to":[122,206],"pinprick,":[123],"performance":[126],"on":[127,150],"Digit":[129],"Symbol":[130],"Substitution":[131],"Test":[132],"Perception":[135],"Speed":[136],"Test.":[137],"The":[138],"results":[139],"demonstrated":[140],"simple":[141],"additivity":[142],"effects":[145],"pinprick":[152],"hyperalgesia,":[153],"impairment.":[156],"We":[157],"conclude":[158],"that,":[159],"at":[160],"least":[161],"experimental":[164],"pain":[165,226],"model,":[166],"there":[167],"is":[168],"no":[169,211],"clear":[170],"advantage":[171,212],"or":[172,203],"disadvantage":[173],"combination":[177,205,215],"equianalgesic":[179],"either":[182,221],"component.":[183],"IMPLICATIONS:":[184],"In":[185],"controlled":[188],"trial,":[189],"administered":[191],"analgesic":[196],"(alfentanil),":[197],"receptor":[200],"antagonist":[201],"(ketamine),":[202],"their":[204],"found":[210],"larger":[218],"dose":[219],"drug":[222],"alone":[223],"relieving":[225],"caused":[227],"by":[228],"painful":[229],"chemical":[230],"stimulation.":[231]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
