{"id":"https://openalex.org/W1997302711","doi":"https://doi.org/10.1155/2014/749724","title":"Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways","display_name":"Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1997302711","doi":"https://doi.org/10.1155/2014/749724","mag":"1997302711","pmid":"https://pubmed.ncbi.nlm.nih.gov/25302307","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4180389"},"language":"en","primary_location":{"id":"doi:10.1155/2014/749724","doi":"https://doi.org/10.1155/2014/749724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/749724","pdf_url":"https://downloads.hindawi.com/journals/bmri/2014/749724.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2014/749724.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043415302","display_name":"Kurataka Otsuka","orcid":"https://orcid.org/0000-0002-9751-1100","observed_orcids":["https://orcid.org/0000-0002-9751-1100"]},"institutions":[{"id":"https://openalex.org/I4405265058","display_name":"Kewpie Corporation (Japan)","ror":"https://ror.org/03rr54c41","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265058"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kurataka Otsuka","raw_affiliation_strings":["Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan","Division of Research and Development, Kewpie Corporation, Sengawa-cho, Chofu-shi, Tokyo 182-0002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Division of Research and Development, Kewpie Corporation, Sengawa-cho, Chofu-shi, Tokyo 182-0002, Japan","institution_ids":["https://openalex.org/I4405265058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006406850","display_name":"Takahiro Ochiya","orcid":"https://orcid.org/0000-0002-0776-9918","observed_orcids":["https://orcid.org/0000-0002-0776-9918","https://orcid.org/0009-0004-1064-6531"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahiro Ochiya","raw_affiliation_strings":["Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan","institution_ids":["https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006406850","https://openalex.org/A5043415302"],"corresponding_institution_ids":["https://openalex.org/I4405265058","https://openalex.org/I4405287541"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":0.7222,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.5726257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2014","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8299999833106995},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8140000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/gene-networks","display_name":"gene networks","score":0.6000000238418579},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8645408749580383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6341818571090698},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6250211000442505},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6128523945808411},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.558154821395874},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5045105218887329},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.49640876054763794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47300225496292114},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3838837742805481},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3523589074611664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34756481647491455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2613815665245056},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2136303186416626}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1155/2014/749724","doi":"https://doi.org/10.1155/2014/749724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/749724","pdf_url":"https://downloads.hindawi.com/journals/bmri/2014/749724.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3161044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4180389","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4180389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4180389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmid:25302307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25302307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.5334","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.5334","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/5c/BMRI2014-749724.PMC4180389.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6016e9615c62476ab4f41191989ad4c7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6016e9615c62476ab4f41191989ad4c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Research International, Vol 2014 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2014/749724","doi":"https://doi.org/10.1155/2014/749724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/749724","pdf_url":"https://downloads.hindawi.com/journals/bmri/2014/749724.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2318146376","display_name":null,"funder_award_id":"P10003","funder_id":"https://openalex.org/F4320321680","funder_display_name":"New Energy and Industrial Technology Development Organization"},{"id":"https://openalex.org/G6980433998","display_name":null,"funder_award_id":"P10003","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8819657034","display_name":null,"funder_award_id":"P10003","funder_id":"https://openalex.org/F4320324144","funder_display_name":"National Institute of Biomedical Innovation"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320310702","display_name":"National Cancer Research Institute","ror":"https://ror.org/02mp0vf47"},{"id":"https://openalex.org/F4320317944","display_name":"Kewpie Corporation","ror":"https://ror.org/03rr54c41"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321680","display_name":"New Energy and Industrial Technology Development Organization","ror":"https://ror.org/0055k7a87"},{"id":"https://openalex.org/F4320324144","display_name":"National Institute of Biomedical Innovation","ror":"https://ror.org/001rkbe13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997302711.pdf","grobid_xml":"https://content.openalex.org/works/W1997302711.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1495672122","https://openalex.org/W1533076763","https://openalex.org/W1563316806","https://openalex.org/W1842367235","https://openalex.org/W1920303762","https://openalex.org/W1939472319","https://openalex.org/W1958284284","https://openalex.org/W1963966397","https://openalex.org/W1964500896","https://openalex.org/W1970431885","https://openalex.org/W1974804765","https://openalex.org/W1975308625","https://openalex.org/W1975390562","https://openalex.org/W1976324983","https://openalex.org/W1976874039","https://openalex.org/W1977372263","https://openalex.org/W1978337436","https://openalex.org/W1978406914","https://openalex.org/W1983817294","https://openalex.org/W1983991097","https://openalex.org/W1984247920","https://openalex.org/W1992508898","https://openalex.org/W1992686564","https://openalex.org/W1992920916","https://openalex.org/W1993199813","https://openalex.org/W1993916353","https://openalex.org/W1996445359","https://openalex.org/W2002995168","https://openalex.org/W2005109475","https://openalex.org/W2006173503","https://openalex.org/W2006797972","https://openalex.org/W2010402627","https://openalex.org/W2011912935","https://openalex.org/W2012753961","https://openalex.org/W2012796327","https://openalex.org/W2013721931","https://openalex.org/W2015519364","https://openalex.org/W2017570593","https://openalex.org/W2021709122","https://openalex.org/W2023495875","https://openalex.org/W2024825778","https://openalex.org/W2030613016","https://openalex.org/W2032541751","https://openalex.org/W2036179093","https://openalex.org/W2036923470","https://openalex.org/W2038167014","https://openalex.org/W2040127848","https://openalex.org/W2042004955","https://openalex.org/W2042198997","https://openalex.org/W2046387002","https://openalex.org/W2048577371","https://openalex.org/W2050869737","https://openalex.org/W2053833990","https://openalex.org/W2056530510","https://openalex.org/W2059848983","https://openalex.org/W2061666056","https://openalex.org/W2062290101","https://openalex.org/W2062515127","https://openalex.org/W2066441178","https://openalex.org/W2066636886","https://openalex.org/W2070765029","https://openalex.org/W2071689359","https://openalex.org/W2074210527","https://openalex.org/W2074545297","https://openalex.org/W2074664629","https://openalex.org/W2081184407","https://openalex.org/W2082500464","https://openalex.org/W2082979850","https://openalex.org/W2083158631","https://openalex.org/W2083381199","https://openalex.org/W2087438476","https://openalex.org/W2095125813","https://openalex.org/W2095916340","https://openalex.org/W2098139456","https://openalex.org/W2099439420","https://openalex.org/W2099692224","https://openalex.org/W2100932663","https://openalex.org/W2106278719","https://openalex.org/W2107462637","https://openalex.org/W2109377963","https://openalex.org/W2109712459","https://openalex.org/W2110666579","https://openalex.org/W2110888067","https://openalex.org/W2112968535","https://openalex.org/W2113239055","https://openalex.org/W2115874527","https://openalex.org/W2119239003","https://openalex.org/W2119337308","https://openalex.org/W2120472737","https://openalex.org/W2120991684","https://openalex.org/W2121787561","https://openalex.org/W2123356446","https://openalex.org/W2123827665","https://openalex.org/W2123961393","https://openalex.org/W2124595934","https://openalex.org/W2125120607","https://openalex.org/W2126426563","https://openalex.org/W2128674168","https://openalex.org/W2128989640","https://openalex.org/W2129355962","https://openalex.org/W2130979840","https://openalex.org/W2132194692","https://openalex.org/W2132531407","https://openalex.org/W2133959309","https://openalex.org/W2135314242","https://openalex.org/W2135836598","https://openalex.org/W2138664009","https://openalex.org/W2139246040","https://openalex.org/W2141605287","https://openalex.org/W2141791387","https://openalex.org/W2143297340","https://openalex.org/W2143377286","https://openalex.org/W2144154026","https://openalex.org/W2146483998","https://openalex.org/W2146642335","https://openalex.org/W2147807172","https://openalex.org/W2147835141","https://openalex.org/W2148180921","https://openalex.org/W2148929244","https://openalex.org/W2149291473","https://openalex.org/W2150536104","https://openalex.org/W2150883469","https://openalex.org/W2152256447","https://openalex.org/W2155131748","https://openalex.org/W2157817316","https://openalex.org/W2158667042","https://openalex.org/W2159266275","https://openalex.org/W2160467221","https://openalex.org/W2160968516","https://openalex.org/W2161027618","https://openalex.org/W2161234257","https://openalex.org/W2162789670","https://openalex.org/W2164073093","https://openalex.org/W2165200432","https://openalex.org/W2166646088","https://openalex.org/W2168230240","https://openalex.org/W2168290712","https://openalex.org/W2169756921","https://openalex.org/W2171407623","https://openalex.org/W2292621739","https://openalex.org/W2338315908"],"related_works":["https://openalex.org/W7098473132","https://openalex.org/W3083605593","https://openalex.org/W1970431885","https://openalex.org/W4308766902","https://openalex.org/W2381943726","https://openalex.org/W2357931808","https://openalex.org/W2032337260","https://openalex.org/W4214865934","https://openalex.org/W2224229617","https://openalex.org/W2136605121"],"abstract_inverted_index":{"During":[0],"the":[1,17,33,52,69,72,85,96,114,131],"past":[2],"ten":[3],"years,":[4],"microRNAs":[5],"(miRNAs)":[6],"have":[7],"been":[8,59],"shown":[9],"to":[10,79,81,103,108],"play":[11],"a":[12,62],"more":[13,43],"significant":[14],"role":[15],"in":[16,30,37,144],"formation":[18],"and":[19,90,99,118,147],"progression":[20],"of":[21,35,54,71,77,87,101,134],"cancer":[22,145],"diseases":[23],"than":[24],"previously":[25],"thought.":[26],"With":[27],"an":[28],"increase":[29],"reports":[31],"about":[32],"dysregulation":[34],"miRNAs":[36,78,93],"diverse":[38],"tumor":[39,64,82],"types,":[40],"it":[41,57],"becomes":[42],"obvious":[44],"that":[45,61,113],"classic":[46],"tumor-suppressive":[47],"molecules":[48],"enter":[49],"deep":[50],"into":[51],"world":[53],"miRNAs.":[55],"Recently,":[56],"has":[58],"demonstrated":[60],"typical":[63],"suppressor":[65],"p53,":[66],"known":[67],"as":[68],"guardian":[70],"genome,":[73],"regulates":[74],"some":[75],"kinds":[76],"contribute":[80],"suppression":[83],"by":[84],"induction":[86],"cell-cycle":[88],"arrest":[89],"apoptosis.":[91],"Meanwhile,":[92],"directly/indirectly":[94],"control":[95,138],"expression":[97],"level":[98],"activity":[100],"p53":[102,110,117],"fine-tune":[104],"its":[105],"functions":[106],"or":[107],"render":[109],"inactive,":[111],"indicating":[112],"interplay":[115],"between":[116],"miRNA":[119],"is":[120],"overly":[121],"complicated.":[122],"The":[123],"findings,":[124],"along":[125],"with":[126],"current":[127],"studies,":[128],"will":[129],"underline":[130],"continuing":[132],"importance":[133],"understanding":[135],"this":[136],"interlocking":[137],"system":[139],"for":[140],"future":[141],"therapeutic":[142],"strategies":[143],"treatment":[146],"prevention.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}