{"id":"https://openalex.org/W1997300966","doi":"https://doi.org/10.1006/taap.1998.8417","title":"Dichloroacetate and Trichloroacetate Promote Clonal Expansion of Anchorage-Independent Hepatocytesin Vivoandin Vitro","display_name":"Dichloroacetate and Trichloroacetate Promote Clonal Expansion of Anchorage-Independent Hepatocytesin Vivoandin Vitro","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1997300966","doi":"https://doi.org/10.1006/taap.1998.8417","mag":"1997300966","pmid":"https://pubmed.ncbi.nlm.nih.gov/9653059"},"language":"en","primary_location":{"id":"doi:10.1006/taap.1998.8417","doi":"https://doi.org/10.1006/taap.1998.8417","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.1998.8417","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047159128","display_name":"Anja J. Stauber","orcid":"https://orcid.org/0000-0001-9389-5832","observed_orcids":["https://orcid.org/0000-0001-9389-5832"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.J. Stauber","raw_affiliation_strings":["Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, USA","Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062319467","display_name":"Richard J. Bull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325736334","display_name":"Battelle","ror":"https://ror.org/01h5tnr73","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1325736334"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.J. Bull","raw_affiliation_strings":["Molecular Biosciences Department, Battelle, Pacific Northwest National Laboratory, Richland, Washington","Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences Department, Battelle, Pacific Northwest National Laboratory, Richland, Washington","institution_ids":["https://openalex.org/I1325736334","https://openalex.org/I142606810"]},{"raw_affiliation_string":"Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110543549","display_name":"Brian D. Thrall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B.D. Thrall","raw_affiliation_strings":["Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology/Toxicology Graduate Program, Washington State University, Pullman, Washington","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110543549"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.3985,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8115942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"150","issue":"2","first_page":"287","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.21860000491142273,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dichloroacetate","display_name":"dichloroacetate","score":1.0},{"id":"https://openalex.org/keywords/trichloroacetate","display_name":"trichloroacetate","score":1.0},{"id":"https://openalex.org/keywords/haloacetic-acids","display_name":"haloacetic acids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8119999766349792},{"id":"https://openalex.org/keywords/plating-density","display_name":"plating density","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7342170476913452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5978410840034485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4012010991573334}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003999","descriptor_name":"Dichloroacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003999","descriptor_name":"Dichloroacetic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014238","descriptor_name":"Trichloroacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014238","descriptor_name":"Trichloroacetic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/taap.1998.8417","doi":"https://doi.org/10.1006/taap.1998.8417","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.1998.8417","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:9653059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9653059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W145522988","https://openalex.org/W1512094340","https://openalex.org/W1580320138","https://openalex.org/W1602406888","https://openalex.org/W1750807446","https://openalex.org/W1966809987","https://openalex.org/W1976385326","https://openalex.org/W1985420122","https://openalex.org/W1985533702","https://openalex.org/W1987593522","https://openalex.org/W1988038204","https://openalex.org/W1994269797","https://openalex.org/W2002279172","https://openalex.org/W2010819439","https://openalex.org/W2020646996","https://openalex.org/W2027500005","https://openalex.org/W2038745662","https://openalex.org/W2046654058","https://openalex.org/W2046983903","https://openalex.org/W2048738951","https://openalex.org/W2052390369","https://openalex.org/W2056508997","https://openalex.org/W2060245506","https://openalex.org/W2062370056","https://openalex.org/W2072157913","https://openalex.org/W2074457872","https://openalex.org/W2077969705","https://openalex.org/W2081317275","https://openalex.org/W2081492585","https://openalex.org/W2082160888","https://openalex.org/W2091749219","https://openalex.org/W2093876701","https://openalex.org/W2095032459","https://openalex.org/W2107152250","https://openalex.org/W2109661077","https://openalex.org/W2120893938","https://openalex.org/W2146788158","https://openalex.org/W4300758206","https://openalex.org/W4322384705","https://openalex.org/W6600319584"],"related_works":["https://openalex.org/W2038745662","https://openalex.org/W1974286731","https://openalex.org/W1976414973","https://openalex.org/W2093876701","https://openalex.org/W2049190631","https://openalex.org/W4206833612","https://openalex.org/W2145144222","https://openalex.org/W7097956229","https://openalex.org/W2131248659","https://openalex.org/W1994868653"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}