{"id":"https://openalex.org/W1997296646","doi":"https://doi.org/10.1016/j.tox.2007.12.014","title":"Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity","display_name":"Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity","publication_year":2007,"publication_date":"2007-12-28","ids":{"openalex":"https://openalex.org/W1997296646","doi":"https://doi.org/10.1016/j.tox.2007.12.014","mag":"1997296646","pmid":"https://pubmed.ncbi.nlm.nih.gov/18243470"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2007.12.014","doi":"https://doi.org/10.1016/j.tox.2007.12.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2007.12.014","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026517567","display_name":"Gary O'Neal Rankin","orcid":"https://orcid.org/0000-0002-5385-3512","observed_orcids":["https://orcid.org/0000-0002-5385-3512"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary O. Rankin","raw_affiliation_strings":["Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. rankin@marshall.edu","Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. rankin@marshall.edu","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113629330","display_name":"S. K. Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suk-kil Hong","raw_affiliation_strings":["Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083025616","display_name":"Dianne K. Anestis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dianne K. Anestis","raw_affiliation_strings":["Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088635150","display_name":"John G. Ball","orcid":"https://orcid.org/0000-0002-1874-8135","observed_orcids":["https://orcid.org/0000-0002-1874-8135"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Ball","raw_affiliation_strings":["Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018878943","display_name":"Monica A. Valentovic","orcid":"https://orcid.org/0000-0001-7065-5721","observed_orcids":["https://orcid.org/0000-0001-7065-5721"]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica A. Valentovic","raw_affiliation_strings":["Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology & Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA","institution_ids":["https://openalex.org/I88694374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026517567"],"corresponding_institution_ids":["https://openalex.org/I88694374"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.14450118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"245","issue":"1-2","first_page":"123","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7577999830245972,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/renal-cortical-slices","display_name":"renal cortical slices","score":0.699999988079071},{"id":"https://openalex.org/keywords/reactive-metabolites","display_name":"reactive metabolites","score":0.6909999847412109},{"id":"https://openalex.org/keywords/co-oxidation","display_name":"CO oxidation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.6570000052452087},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9480000138282776},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8420000076293945},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cysteine-conjugate-beta-lyase","display_name":"cysteine conjugate beta-lyase","score":0.7160000205039978},{"id":"https://openalex.org/keywords/organic-anion-transport","display_name":"organic anion transport","score":0.6470000147819519},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-release","display_name":"lactate dehydrogenase release","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7775320410728455},{"id":"https://openalex.org/C2780730560","wikidata":"https://www.wikidata.org/wiki/Q209205","display_name":"2,4-Dichlorophenol","level":3,"score":0.7096640467643738},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6992606520652771},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5499035716056824},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.49586543440818787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39461827278137207},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3793249726295471},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.34855616092681885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27300408482551575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26832014322280884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10705196857452393},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08067566156387329},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002733","descriptor_name":"Chlorophenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2007.12.014","doi":"https://doi.org/10.1016/j.tox.2007.12.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2007.12.014","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:18243470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18243470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1576815711","https://openalex.org/W1780672101","https://openalex.org/W1805378417","https://openalex.org/W1966771686","https://openalex.org/W1975883602","https://openalex.org/W1980582852","https://openalex.org/W1982169002","https://openalex.org/W1985893449","https://openalex.org/W1990224230","https://openalex.org/W1994475612","https://openalex.org/W1999717857","https://openalex.org/W2004464824","https://openalex.org/W2006248594","https://openalex.org/W2030318391","https://openalex.org/W2031431690","https://openalex.org/W2050415328","https://openalex.org/W2051620692","https://openalex.org/W2052015807","https://openalex.org/W2053919514","https://openalex.org/W2062453634","https://openalex.org/W2066583840","https://openalex.org/W2066812217","https://openalex.org/W2067685349","https://openalex.org/W2071836082","https://openalex.org/W2080069513","https://openalex.org/W2086376951","https://openalex.org/W2090477151","https://openalex.org/W2092249878","https://openalex.org/W2095498024","https://openalex.org/W2133515745","https://openalex.org/W2143310401","https://openalex.org/W2157514229","https://openalex.org/W2162659089","https://openalex.org/W2164318291","https://openalex.org/W2166939062","https://openalex.org/W2185110452","https://openalex.org/W2898020700","https://openalex.org/W4406984086"],"related_works":["https://openalex.org/W2086376951","https://openalex.org/W3174568641","https://openalex.org/W2006248594","https://openalex.org/W1999430001","https://openalex.org/W3173616949","https://openalex.org/W2014993686","https://openalex.org/W1975883602","https://openalex.org/W7098190500","https://openalex.org/W4252411182","https://openalex.org/W2291806496"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
