{"id":"https://openalex.org/W1997294622","doi":"https://doi.org/10.1021/js9800174","title":"Sugar\u2013polymer hydrogen bond interactions in lyophilized amorphous mixtures","display_name":"Sugar\u2013polymer hydrogen bond interactions in lyophilized amorphous mixtures","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1997294622","doi":"https://doi.org/10.1021/js9800174","mag":"1997294622","pmid":"https://pubmed.ncbi.nlm.nih.gov/10189276"},"language":"en","primary_location":{"id":"doi:10.1021/js9800174","doi":"https://doi.org/10.1021/js9800174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/js9800174","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090835640","display_name":"Lynne S. Taylor","orcid":"https://orcid.org/0000-0002-4568-6021","observed_orcids":["https://orcid.org/0000-0002-4568-6021"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne S. Taylor","raw_affiliation_strings":["School of Pharmacy, University of Wisconsin-Madison, 53706, USA","School of Pharmacy, University of WisconsinsMadison, 425 North Charter Street, Madison, Wisconsin, 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin-Madison, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"School of Pharmacy, University of WisconsinsMadison, 425 North Charter Street, Madison, Wisconsin, 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039878143","display_name":"George Zografi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George Zografi","raw_affiliation_strings":["School of Pharmacy, University of WisconsinsMadison, 425 North Charter Street, Madison, Wisconsin, 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of WisconsinsMadison, 425 North Charter Street, Madison, Wisconsin, 53706","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039878143"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":4.8407,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.95700314,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"87","issue":"12","first_page":"1615","last_page":"1621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10474","display_name":"Material Dynamics and Properties","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10474","display_name":"Material Dynamics and Properties","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10544","display_name":"Glass properties and applications","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2503","display_name":"Ceramics and Composites"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8180000185966492},{"id":"https://openalex.org/keywords/amorphous-solid-dispersions","display_name":"amorphous solid dispersions","score":0.847000002861023},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8069999814033508},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glass-transition-temperature","display_name":"glass transition temperature","score":0.7699999809265137},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.9610000252723694},{"id":"https://openalex.org/keywords/trehalose","display_name":"trehalose","score":0.9980000257492065},{"id":"https://openalex.org/keywords/raffinose","display_name":"raffinose","score":0.9959999918937683},{"id":"https://openalex.org/keywords/maltodextrin","display_name":"maltodextrin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/disaccharides","display_name":"disaccharides","score":0.9549999833106995},{"id":"https://openalex.org/keywords/thermodynamics-of-mixing","display_name":"thermodynamics of mixing","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ft-raman-spectroscopy","display_name":"FT-Raman spectroscopy","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7951911687850952},{"id":"https://openalex.org/C122865956","wikidata":"https://www.wikidata.org/wiki/Q825643","display_name":"Glass transition","level":3,"score":0.750449538230896},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6841424107551575},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.6629270911216736},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.660106897354126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6043199896812439},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5887856483459473},{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.5494123101234436},{"id":"https://openalex.org/C2777846834","wikidata":"https://www.wikidata.org/wiki/Q177570","display_name":"Maltodextrin","level":3,"score":0.518650233745575},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.35610851645469666},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.33197471499443054},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.23546478152275085},{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.1262304186820984},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.09769058227539062},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004187","descriptor_name":"Disaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005612","descriptor_name":"Freeze Drying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008320","descriptor_name":"Maltose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011205","descriptor_name":"Povidone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014312","descriptor_name":"Trisaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/js9800174","doi":"https://doi.org/10.1021/js9800174","is_oa":false,"landing_page_url":"https://doi.org/10.1021/js9800174","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:10189276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10189276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W13308618","https://openalex.org/W112580190","https://openalex.org/W159322865","https://openalex.org/W1489640652","https://openalex.org/W1600549048","https://openalex.org/W1605467703","https://openalex.org/W1977640937","https://openalex.org/W1986072821","https://openalex.org/W1987538717","https://openalex.org/W1989452602","https://openalex.org/W1989801989","https://openalex.org/W2001682539","https://openalex.org/W2006850991","https://openalex.org/W2007999038","https://openalex.org/W2014213512","https://openalex.org/W2022071216","https://openalex.org/W2022871296","https://openalex.org/W2024118271","https://openalex.org/W2043700769","https://openalex.org/W2047037301","https://openalex.org/W2047948690","https://openalex.org/W2048016595","https://openalex.org/W2048421180","https://openalex.org/W2060024541","https://openalex.org/W2073352795","https://openalex.org/W2075179133","https://openalex.org/W2076578690","https://openalex.org/W2084893331","https://openalex.org/W2086555498","https://openalex.org/W2151480464","https://openalex.org/W2151491292","https://openalex.org/W2333575373","https://openalex.org/W2480487131","https://openalex.org/W2500620862","https://openalex.org/W4247727653","https://openalex.org/W4249000196"],"related_works":["https://openalex.org/W2026416057","https://openalex.org/W2088155929","https://openalex.org/W1989801989","https://openalex.org/W2054101065","https://openalex.org/W2312186031","https://openalex.org/W2323416132","https://openalex.org/W2057956836","https://openalex.org/W4306742848","https://openalex.org/W2058263077","https://openalex.org/W2075648788"],"abstract_inverted_index":{"The":[0,31,48,108,137],"objective":[1],"of":[2,14,35,110,123,139,146],"this":[3],"work":[4],"was":[5,63,113],"to":[6,65,68,95,102,115,129,143],"investigate":[7],"hydrogen":[8,49,66,96,111,130,140],"bonding":[9,50,112,141],"interactions":[10,51,142],"between":[11,52],"a":[12,18,69,75,92],"variety":[13],"glass-forming":[15],"sugars":[16,37],"and":[17,38,55,86],"model":[19],"polymer,":[20],"poly(vinylpyrrolidone)":[21],"(PVP),":[22],"in":[23,148],"binary":[24],"amorphous":[25,149],"solid":[26],"solutions,":[27],"produced":[28],"by":[29],"lyophilization.":[30],"glass":[32,120],"transition":[33,121],"temperatures":[34],"the":[36,80,87,99,103,119,124,127,134,144],"sugar-PVP":[39],"colyophilized":[40],"mixtures":[41],"were":[42,57],"assessed":[43],"using":[44,59],"differential":[45],"scanning":[46],"calorimetry.":[47],"each":[53],"sugar":[54],"PVP":[56,73],"monitored":[58],"FT-Raman":[60],"spectroscopy.":[61],"Sucrose":[62],"found":[64,114],"bond":[67,97,131],"greater":[70],"extent":[71,109],"with":[72,98,118,126],"at":[74],"particular":[76],"sugar:polymer":[77],"ratio":[78],"than":[79],"other":[81],"disaccharides":[82],"studied":[83],"including":[84],"trehalose":[85],"trisaccharide":[88],"raffinose.":[89],"Maltodextrins":[90],"showed":[91],"decreased":[93],"tendency":[94,128],"polymer":[100],"compared":[101],"lower":[104],"molecular":[105],"weight":[106],"sugars.":[107],"correlate":[116],"inversely":[117],"temperature":[122],"sugar,":[125],"decreasing":[132],"as":[133],"Tg":[135],"increased.":[136],"importance":[138],"thermodynamics":[145],"mixing":[147],"solids":[150],"is":[151],"discussed.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
