{"id":"https://openalex.org/W1997293297","doi":"https://doi.org/10.1186/1753-6561-5-s9-s15","title":"Comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression","display_name":"Comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression","publication_year":2011,"publication_date":"2011-11-29","ids":{"openalex":"https://openalex.org/W1997293297","doi":"https://doi.org/10.1186/1753-6561-5-s9-s15","mag":"1997293297","pmid":"https://pubmed.ncbi.nlm.nih.gov/22373501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3287849"},"language":"en","primary_location":{"id":"doi:10.1186/1753-6561-5-s9-s15","doi":"https://doi.org/10.1186/1753-6561-5-s9-s15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-5-s9-s15","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-5-S9-S15","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-5-S9-S15","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072612227","display_name":"Heejong Sung","orcid":"https://orcid.org/0000-0002-2329-326X","observed_orcids":["https://orcid.org/0000-0002-2329-326X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heejong Sung","raw_affiliation_strings":["Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA. afw@mail.nih.gov","Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA. afw@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014151353","display_name":"Yoonhee Kim","orcid":"https://orcid.org/0000-0003-2517-1087","observed_orcids":["https://orcid.org/0000-0003-2517-1087"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoonhee Kim","raw_affiliation_strings":["Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066928744","display_name":"Juanliang Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juanliang Cai","raw_affiliation_strings":["Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009315889","display_name":"Cheryl D. Cropp","orcid":"https://orcid.org/0000-0001-7662-9567","observed_orcids":["https://orcid.org/0000-0001-7662-9567"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl D Cropp","raw_affiliation_strings":["Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011669663","display_name":"Claire L. Simpson","orcid":"https://orcid.org/0000-0003-2244-7690","observed_orcids":["https://orcid.org/0000-0003-2244-7690"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire L Simpson","raw_affiliation_strings":["Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404194","display_name":"Qing Li","orcid":"https://orcid.org/0009-0005-1327-4347","observed_orcids":["https://orcid.org/0009-0005-1327-4347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064936196","display_name":"Brian C Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C Perry","raw_affiliation_strings":["Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043718031","display_name":"Alexa J.M. Sorant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa JM Sorant","raw_affiliation_strings":["Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067921126","display_name":"Joan Wilson","orcid":"https://orcid.org/0000-0002-9153-2920","observed_orcids":["https://orcid.org/0000-0002-9153-2920"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan E Bailey-Wilson","raw_affiliation_strings":["Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091519811","display_name":"Alexander F. Wilson","orcid":"https://orcid.org/0000-0002-6682-8156","observed_orcids":["https://orcid.org/0000-0002-6682-8156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander F Wilson","raw_affiliation_strings":["Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091519811"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.7981,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72043562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"S9","first_page":"S15","last_page":"S15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rare-variant-association","display_name":"rare variant association","score":0.777999997138977},{"id":"https://openalex.org/keywords/type-i-error-rate","display_name":"type I error rate","score":0.6830000281333923},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.8989999890327454},{"id":"https://openalex.org/keywords/quantitative-traits","display_name":"quantitative traits","score":0.5839999914169312},{"id":"https://openalex.org/keywords/genetic-analysis-workshop-17","display_name":"Genetic Analysis Workshop 17","score":0.8930000066757202},{"id":"https://openalex.org/keywords/allelic-effects","display_name":"allelic effects","score":0.7450000047683716},{"id":"https://openalex.org/keywords/linear-regression","display_name":"linear regression","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.7218484878540039},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.6995232701301575},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.626148521900177},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.5774325132369995},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.5761587023735046},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5234586596488953},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4626975655555725},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.4588513970375061},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.4364165663719177},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41979730129241943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.338773638010025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29192855954170227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2548476457595825},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25305044651031494},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.17945361137390137},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17719492316246033},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1004205048084259},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1753-6561-5-s9-s15","doi":"https://doi.org/10.1186/1753-6561-5-s9-s15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-5-s9-s15","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-5-S9-S15","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3287849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3287849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proc","raw_type":"Text"},{"id":"pmid:22373501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22373501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC proceedings","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1753-6561-5-s9-s15","doi":"https://doi.org/10.1186/1753-6561-5-s9-s15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-5-s9-s15","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-5-S9-S15","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G736005061","display_name":"Genetic Analysis of Common Diseases: An Evaluation","funder_award_id":"R01GM031575","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997293297.pdf","grobid_xml":"https://content.openalex.org/works/W1997293297.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2012415418","https://openalex.org/W2058148991","https://openalex.org/W2104776392","https://openalex.org/W2108169091","https://openalex.org/W2161633633"],"related_works":["https://openalex.org/W2211503200","https://openalex.org/W2535960470","https://openalex.org/W2104776392","https://openalex.org/W2095170841","https://openalex.org/W2078857258","https://openalex.org/W2068764129","https://openalex.org/W2013078253","https://openalex.org/W2136677697","https://openalex.org/W2063078058","https://openalex.org/W2058148991"],"abstract_inverted_index":{"Tiled":[0],"regression":[1,42,92,168],"is":[2,145,164],"an":[3],"approach":[4],"designed":[5],"to":[6,16,64,72,94,116],"determine":[7],"the":[8,17,24,36,40,45,62,78,83,90,114,126,139,148],"set":[9],"of":[10,19,26,39,97,120,156],"independent":[11],"genetic":[12],"variants":[13,75,111,124],"that":[14,108],"contribute":[15],"variation":[18],"a":[20],"quantitative":[21],"trait":[22,149],"in":[23,51],"presence":[25],"many":[27],"highly":[28],"correlated":[29],"variants.":[30,104],"In":[31,86],"this":[32],"study,":[33],"we":[34,68,88],"evaluate":[35],"statistical":[37],"properties":[38],"tiled":[41,91,167],"method":[43,93],"using":[44],"Genetic":[46],"Analysis":[47],"Workshop":[48],"17":[49],"data":[50],"unrelated":[52],"individuals":[53],"for":[54,134,166],"traits":[55],"Q1,":[56],"Q2,":[57],"and":[58,76,100,150],"Q4.":[59],"To":[60],"increase":[61],"power":[63,115],"detect":[65,117],"rare":[66,74,103,110],"variants,":[67],"use":[69],"two":[70],"methods":[71],"collapse":[73],"compare":[77,89],"results":[79,106],"with":[80,99,125],"those":[81],"from":[82],"uncollapsed":[84],"data.":[85],"addition,":[87],"traditional":[95,135],"tests":[96],"association":[98],"without":[101],"collapsed":[102],"The":[105,158],"show":[107],"collapsing":[109],"generally":[112],"improves":[113],"associations":[118],"regardless":[119],"method,":[121],"although":[122],"only":[123],"largest":[127],"allelic":[128],"effects":[129],"could":[130],"be":[131],"detected.":[132],"However,":[133],"simple":[136],"linear":[137],"regression,":[138],"average":[140],"estimated":[141,159],"type":[142,160],"I":[143,161],"error":[144,162],"dependent":[146],"on":[147],"varies":[151],"by":[152],"about":[153],"three":[154],"orders":[155],"magnitude.":[157],"rate":[163],"stable":[165],"across":[169],"traits.":[170]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}