{"id":"https://openalex.org/W1997288239","doi":"https://doi.org/10.1001/archneur.1993.00540020011006","title":"Psychopathology in Metachromatic Leukodystrophy-Reply","display_name":"Psychopathology in Metachromatic Leukodystrophy-Reply","publication_year":1993,"publication_date":"1993-02-01","ids":{"openalex":"https://openalex.org/W1997288239","doi":"https://doi.org/10.1001/archneur.1993.00540020011006","mag":"1997288239"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.1993.00540020011006","doi":"https://doi.org/10.1001/archneur.1993.00540020011006","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1993.00540020011006","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056413476","display_name":"Thomas M. Hyde","orcid":"https://orcid.org/0000-0002-8746-3037","observed_orcids":["https://orcid.org/0000-0002-8746-3037"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Hyde","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. C. Ziegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Ziegler","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043264677","display_name":"Daniel R. Weinberger","orcid":"https://orcid.org/0000-0003-2409-2969","observed_orcids":["https://orcid.org/0000-0003-2409-2969","https://orcid.org/0000-0003-1178-8086"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. R. Weinberger","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13467593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"50","issue":"2","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metachromatic-leukodystrophy","display_name":"metachromatic leukodystrophy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/psychopathology","display_name":"psychopathology","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8679999709129333},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776326100","wikidata":"https://www.wikidata.org/wiki/Q1120682","display_name":"Metachromatic leukodystrophy","level":2,"score":0.9362390041351318},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7774261236190796},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.5982553362846375},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5919862985610962},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5903964042663574},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5199036002159119},{"id":"https://openalex.org/C541082541","wikidata":"https://www.wikidata.org/wiki/Q192560","display_name":"Limbic system","level":3,"score":0.4870308041572571},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.424007385969162},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.3255155384540558},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.16226449608802795},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10343867540359497}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/archneur.1993.00540020011006","doi":"https://doi.org/10.1001/archneur.1993.00540020011006","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1993.00540020011006","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W110230828","https://openalex.org/W1934525866","https://openalex.org/W1983805449","https://openalex.org/W1995362640","https://openalex.org/W2042649681","https://openalex.org/W2128230812"],"related_works":["https://openalex.org/W2072902555","https://openalex.org/W2128230812","https://openalex.org/W4242849732","https://openalex.org/W1999350213","https://openalex.org/W2414157187","https://openalex.org/W4232393892","https://openalex.org/W2419071720","https://openalex.org/W2419003224","https://openalex.org/W2411958467","https://openalex.org/W2439703828"],"abstract_inverted_index":{"In":[0],"Reply.":[1],"\u2014We":[2],"appreciate":[3],"the":[4,40,50,97,103,117,123,126,134],"comments":[5],"from":[6,133],"Merriam":[7],"and":[8,26],"Hegarty":[9],"regarding":[10],"our":[11,37,64],"recently":[12],"published":[13],"article":[14],"about":[15],"psychosis":[16,69,131],"in":[17,36,45,61,63],"metachromatic":[18],"leukodystrophy.1We":[19],"were":[20,91],"aware":[21],"of":[22,42,74,77,87,120,125,136],"their":[23,27,46],"case":[24],"report":[25],"other":[28],"publications.":[29],"Their":[30],"case,":[31],"however,":[32],"was":[33,107],"not":[34],"included":[35],"review":[38],"because":[39],"age":[41,51],"clinical":[43],"onset":[44],"patient":[47],"fell":[48],"outside":[49],"group":[52],"(12":[53],"to":[54,72,93],"30":[55],"years)":[56],"that":[57,68,130],"we":[58],"focused":[59],"on":[60],"detail":[62],"article.":[65],"The":[66],"hypothesis":[67],"is":[70],"related":[71],"disruption":[73],"neocortical":[75],"regulation":[76],"limbic":[78,140],"systems":[79],"has":[80],"a":[81,85],"long":[82],"history,":[83],"with":[84],"variety":[86],"incarnations.":[88],"If":[89],"one":[90],"compelled":[92],"determine":[94],"its":[95],"origin,":[96],"task":[98],"would":[99],"be":[100],"daunting":[101],"at":[102],"least.":[104],"It":[105],"probably":[106],"first":[108],"articulated":[109],"clearly":[110],"by":[111],"MacLean,2who":[112],"stressed":[113],"neocortical-limbic":[114],"connectivity":[115],"as":[116],"neural":[118],"substrate":[119],"psychosis.":[121],"Nauta3emphasized":[122],"role":[124],"prefrontal":[127,137],"cortex,":[128],"suggesting":[129],"resulted":[132],"loss":[135],"control":[138],"over":[139],"activity.":[141],"More":[142]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}