{"id":"https://openalex.org/W1997282583","doi":"https://doi.org/10.1016/0140-6736(93)90488-3","title":"Reliability of polymerase chain reaction for detection of hepatitis C virus","display_name":"Reliability of polymerase chain reaction for detection of hepatitis C virus","publication_year":1993,"publication_date":"1993-03-01","ids":{"openalex":"https://openalex.org/W1997282583","doi":"https://doi.org/10.1016/0140-6736(93)90488-3","mag":"1997282583","pmid":"https://pubmed.ncbi.nlm.nih.gov/8095626"},"language":"en","primary_location":{"id":"doi:10.1016/0140-6736(93)90488-3","doi":"https://doi.org/10.1016/0140-6736(93)90488-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0140-6736(93)90488-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091240947","display_name":"Hans L. Zaaijer","orcid":"https://orcid.org/0000-0003-0773-7315","observed_orcids":["https://orcid.org/0000-0003-0773-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.L. Zaaijer","raw_affiliation_strings":["Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111729231","display_name":"H.T.M. Cuypers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.T.M. Cuypers","raw_affiliation_strings":["Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070630828","display_name":"Henk W. Reesink","orcid":"https://orcid.org/0000-0002-5298-2494","observed_orcids":["https://orcid.org/0000-0002-5298-2494","https://orcid.org/0000-0002-6199-9247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.W. Reesink","raw_affiliation_strings":["Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040010646","display_name":"I.N. Winkel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I.N. Winkel","raw_affiliation_strings":["Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109852561","display_name":"P.N. Lelie","orcid":"https://orcid.org/0000-0003-1043-661X","observed_orcids":["https://orcid.org/0000-0003-1043-661X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P.N. Lelie","raw_affiliation_strings":["Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eurohep Concerted Action on Viral Hepatitis (Eurohep), Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018899274","display_name":"Guido Gerken","orcid":"https://orcid.org/0000-0001-6734-5001","observed_orcids":["https://orcid.org/0000-0001-6734-5001"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Gerken","raw_affiliation_strings":["Medizinische Klinik und Poliklinik, Universit\u00e4t Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik, Universit\u00e4t Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109852561"],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":48.6066,"has_fulltext":false,"cited_by_count":391,"citation_normalized_percentile":{"value":0.99932592,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"341","issue":"8847","first_page":"722","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hcv-rna-detection","display_name":"HCV RNA detection","score":0.972000002861023},{"id":"https://openalex.org/keywords/pcr","display_name":"PCR","score":0.8489999771118164},{"id":"https://openalex.org/keywords/assay-reliability","display_name":"assay reliability","score":0.796999990940094},{"id":"https://openalex.org/keywords/interlaboratory-comparison","display_name":"interlaboratory comparison","score":0.7239999771118164},{"id":"https://openalex.org/keywords/false-negative-results","display_name":"false-negative results","score":0.7450000047683716},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.8109999895095825},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.3959999978542328},{"id":"https://openalex.org/keywords/plasma-samples","display_name":"plasma samples","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6281884908676147},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.6181386113166809},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6009538173675537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.507129430770874},{"id":"https://openalex.org/C2909814700","wikidata":"https://www.wikidata.org/wiki/Q18207010","display_name":"False Negative Reactions","level":2,"score":0.4939749836921692},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.47248807549476624},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45531731843948364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28805190324783325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2780172824859619},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09617593884468079},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09387239813804626}],"mesh":[{"descriptor_ui":"D005188","descriptor_name":"False Negative Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019411","descriptor_name":"Clinical Laboratory Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/0140-6736(93)90488-3","doi":"https://doi.org/10.1016/0140-6736(93)90488-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0140-6736(93)90488-3","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:8095626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8095626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/d451d39e-e1a0-4517-b177-73c989e520b2","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/reliability-of-polymerase-chain-reaction-for-detection-of-hepatitis-c-virus(d451d39e-e1a0-4517-b177-73c989e520b2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lancet, 341(8847), 722 - 724. Elsevier Limited","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e20aa342-3739-4feb-9304-95f0e7f4f42f","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e20aa342-3739-4feb-9304-95f0e7f4f42f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zaaijer, H L, Cuypers, H T, Reesink, H W, Winkel, I N, Gerken, G & Lelie, P N 1993, 'Reliability of polymerase chain reaction for detection of hepatitis C virus', Lancet, vol. 341, no. 8847, pp. 722-724. https://doi.org/10.1016/0140-6736(93)90488-3","raw_type":"info:eu-repo/semantics/annotation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1517480469","https://openalex.org/W1968954796","https://openalex.org/W2002170053","https://openalex.org/W2073276419","https://openalex.org/W2079020481","https://openalex.org/W2134812217","https://openalex.org/W2166229810"],"related_works":["https://openalex.org/W1977504685","https://openalex.org/W2429679126","https://openalex.org/W2351515537","https://openalex.org/W2137130199","https://openalex.org/W7008394893","https://openalex.org/W4229673313","https://openalex.org/W2472172455","https://openalex.org/W2064186866","https://openalex.org/W2397843321","https://openalex.org/W7217048438"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}