{"id":"https://openalex.org/W1997279293","doi":"https://doi.org/10.1016/s0006-3495(99)77415-1","title":"Lipid Composition and the Lateral Pressure Profile in Bilayers","display_name":"Lipid Composition and the Lateral Pressure Profile in Bilayers","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1997279293","doi":"https://doi.org/10.1016/s0006-3495(99)77415-1","mag":"1997279293","pmid":"https://pubmed.ncbi.nlm.nih.gov/10233077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1300232"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-3495(99)77415-1","doi":"https://doi.org/10.1016/s0006-3495(99)77415-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(99)77415-1","pdf_url":"http://www.cell.com/article/S0006349599774151/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1997279293"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0006349599774151/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089456906","display_name":"Robert S. Cantor","orcid":"https://orcid.org/0000-0003-3355-0546","observed_orcids":["https://orcid.org/0000-0003-3355-0546"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert S. Cantor","raw_affiliation_strings":["The Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA. rcantor@dartmouth.edu","The Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA. rcantor@dartmouth.edu","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"The Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089456906"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":4.6926,"has_fulltext":false,"cited_by_count":459,"citation_normalized_percentile":{"value":0.96077798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"76","issue":"5","first_page":"2625","last_page":"2639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-composition","display_name":"lipid composition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lateral-pressure-profile","display_name":"lateral pressure profile","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.8500000238418579},{"id":"https://openalex.org/keywords/membrane-thickness","display_name":"membrane thickness","score":0.5479999780654907},{"id":"https://openalex.org/keywords/hydrophobic-mismatch","display_name":"hydrophobic mismatch","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7120000123977661},{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chain-length","display_name":"chain length","score":0.5350000262260437},{"id":"https://openalex.org/keywords/alkanols","display_name":"alkanols","score":0.6970000267028809},{"id":"https://openalex.org/keywords/membrane-protein-function","display_name":"membrane protein function","score":0.8050000071525574},{"id":"https://openalex.org/keywords/molecular-area","display_name":"molecular area","score":0.7829999923706055},{"id":"https://openalex.org/keywords/statistical-mechanics","display_name":"statistical mechanics","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C201268389","wikidata":"https://www.wikidata.org/wiki/Q905639","display_name":"Degree of unsaturation","level":2,"score":0.9072307348251343},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7243410348892212},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7172966003417969},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6647964119911194},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6472107172012329},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4590602517127991},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44649142026901245},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.34630119800567627},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.23506242036819458},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2264326512813568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18143892288208008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06938746571540833},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0006-3495(99)77415-1","doi":"https://doi.org/10.1016/s0006-3495(99)77415-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(99)77415-1","pdf_url":"http://www.cell.com/article/S0006349599774151/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmid:10233077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10233077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1300232","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1300232/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.539.7122","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.539.7122","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.dartmouth.edu/~rcantor/BPJ99a.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/s0006-3495(99)77415-1","doi":"https://doi.org/10.1016/s0006-3495(99)77415-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(99)77415-1","pdf_url":"http://www.cell.com/article/S0006349599774151/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1997279293.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W178354323","https://openalex.org/W283307160","https://openalex.org/W595744503","https://openalex.org/W600590637","https://openalex.org/W607690890","https://openalex.org/W654417284","https://openalex.org/W1533275683","https://openalex.org/W1535007134","https://openalex.org/W1540205595","https://openalex.org/W1835482150","https://openalex.org/W1964809614","https://openalex.org/W1965976339","https://openalex.org/W1966256199","https://openalex.org/W1975068702","https://openalex.org/W1978195377","https://openalex.org/W1983439040","https://openalex.org/W1984813792","https://openalex.org/W1987604530","https://openalex.org/W1993611155","https://openalex.org/W1994215475","https://openalex.org/W1994876448","https://openalex.org/W1995002044","https://openalex.org/W1999698653","https://openalex.org/W2004315725","https://openalex.org/W2004981027","https://openalex.org/W2006993514","https://openalex.org/W2007960243","https://openalex.org/W2015401371","https://openalex.org/W2018142647","https://openalex.org/W2018514315","https://openalex.org/W2020835297","https://openalex.org/W2026885029","https://openalex.org/W2032837243","https://openalex.org/W2050760568","https://openalex.org/W2051792483","https://openalex.org/W2054206182","https://openalex.org/W2055122725","https://openalex.org/W2061792388","https://openalex.org/W2065061795","https://openalex.org/W2072511617","https://openalex.org/W2078995260","https://openalex.org/W2079205673","https://openalex.org/W2081025398","https://openalex.org/W2090241067","https://openalex.org/W2092068407","https://openalex.org/W2096995495","https://openalex.org/W2097769570","https://openalex.org/W2114469046","https://openalex.org/W2129365131","https://openalex.org/W2135044922","https://openalex.org/W2151929256","https://openalex.org/W2159149836","https://openalex.org/W2163025802","https://openalex.org/W2174326934","https://openalex.org/W2494135302","https://openalex.org/W2577338546"],"related_works":["https://openalex.org/W2078995260","https://openalex.org/W2044092676","https://openalex.org/W312309775","https://openalex.org/W2114922134","https://openalex.org/W2345994378","https://openalex.org/W1991186550","https://openalex.org/W2072599573","https://openalex.org/W2017965509"],"abstract_inverted_index":{"The":[0],"mechanisms":[1],"by":[2],"which":[3,33],"variations":[4],"in":[5,32,35,45,90,175],"the":[6,13,54,63,135,143,146,186,194],"lipid":[7,36,78],"composition":[8,37],"of":[9,15,41,58,62,75,82,96,104,111,126,134,149,151,166,185,193],"cell":[10],"membranes":[11],"influence":[12],"function":[14,179],"membrane":[16,177],"proteins":[17],"are":[18,70,85,114,203],"not":[19],"yet":[20],"well":[21],"understood.":[22],"In":[23,53],"recent":[24],"work,":[25],"a":[26,39,73,191],"nonlocal":[27],"thermodynamic":[28,60],"mechanism":[29],"was":[30],"suggested":[31],"changes":[34,113],"cause":[38],"redistribution":[40],"lateral":[42,83],"pressures":[43],"that":[44,116,142],"turn":[46],"modulates":[47],"protein":[48,178],"conformational":[49],"(or":[50],"aggregation)":[51],"equilibria.":[52],"present":[55],"study,":[56],"results":[57,162],"statistical":[59],"calculations":[61],"equilibrium":[64],"pressure":[65,84,136,147,187],"profile":[66,148,188],"and":[67,77,94,102,106,172,180,199,207],"bilayer":[68,121],"thickness":[69],"reported":[71],"for":[72],"range":[74],"lipids":[76],"mixtures.":[79],"Large":[80],"redistributions":[81],"predicted":[86,141],"to":[87,120],"accompany":[88],"variation":[89],"chain":[91,97],"length,":[92],"degree":[93],"position":[95],"unsaturation,":[98],"head":[99],"group":[100],"repulsion,":[101],"incorporation":[103],"cholesterol":[105],"interfacially":[107],"active":[108],"solutes.":[109],"Combinations":[110],"compositional":[112],"found":[115],"compensate":[117],"with":[118,157,205],"respect":[119],"thickness,":[122],"thus":[123],"eliminating":[124],"effects":[125],"hydrophobic":[127],"mismatch,":[128],"while":[129],"still":[130],"effecting":[131],"significant":[132],"shifts":[133],"profile.":[137],"It":[138],"is":[139],"also":[140],"effect":[144],"on":[145],"addition":[150],"short":[152],"alkanols":[153],"can":[154],"be":[155],"reproduced":[156],"certain":[158],"unnatural":[159],"lipids.":[160],"These":[161],"suggest":[163,181],"possible":[164],"roles":[165],"cholesterol,":[167],"highly":[168],"unsaturated":[169],"fatty":[170],"acids":[171],"small":[173],"solutes":[174],"modulating":[176],"unambiguous":[182],"experimental":[183,206],"tests":[184],"hypothesis.":[189],"As":[190],"test":[192],"methodology,":[195],"calculated":[196],"molecular":[197],"areas":[198],"area":[200],"elastic":[201],"moduli":[202],"compared":[204],"simulation":[208],"results.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}