{"id":"https://openalex.org/W1997275703","doi":"https://doi.org/10.1089/153685902321043990","title":"In Vivo and In Vitro Anti-Tumor Effect of 14F7 Monoclonal Antibody","display_name":"In Vivo and In Vitro Anti-Tumor Effect of 14F7 Monoclonal Antibody","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W1997275703","doi":"https://doi.org/10.1089/153685902321043990","mag":"1997275703","pmid":"https://pubmed.ncbi.nlm.nih.gov/12573110"},"language":"en","primary_location":{"id":"doi:10.1089/153685902321043990","doi":"https://doi.org/10.1089/153685902321043990","is_oa":false,"landing_page_url":"https://doi.org/10.1089/153685902321043990","pdf_url":null,"source":{"id":"https://openalex.org/S199469938","display_name":"Hybridoma and Hybridomics","issn_l":"1536-8599","issn":["1536-8599","1557-8097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma and Hybridomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078659992","display_name":"Adriana Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Adriana Carr","raw_affiliation_strings":["Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042590883","display_name":"Circe Mesa","orcid":"https://orcid.org/0000-0001-8342-7779","observed_orcids":["https://orcid.org/0000-0001-8342-7779"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Circe Mesa","raw_affiliation_strings":["Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091340487","display_name":"Mar\u00eda del Carmen Arango","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087066","display_name":"Instituto de Oncolog\u00eda y Radiobiolog\u00eda","ror":"https://ror.org/000kkgk42","country_code":"CU","type":"healthcare","lineage":["https://openalex.org/I4210087066"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mar\u00eda del Carmen Arango","raw_affiliation_strings":["National Radiobiology and Oncology Institute, Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Radiobiology and Oncology Institute, Havana, Cuba","institution_ids":["https://openalex.org/I4210087066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101936588","display_name":"Ana Mar\u00eda V\u00e1zquez","orcid":"https://orcid.org/0000-0003-1265-5066","observed_orcids":["https://orcid.org/0000-0003-1265-5066"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Ana Mar\u00eda V\u00e1zquez","raw_affiliation_strings":["Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101935427","display_name":"Luis Enrique Fernandez","orcid":"https://orcid.org/0000-0002-6779-3952","observed_orcids":["https://orcid.org/0000-0002-6779-3952"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Luis Enrique Fern\u00e1ndez","raw_affiliation_strings":["Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4216,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.57807727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"21","issue":"6","first_page":"463","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm3-ganglioside","display_name":"GM3 ganglioside","score":0.9169999957084656},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/agglutinins","display_name":"agglutinins","score":0.6589999794960022},{"id":"https://openalex.org/keywords/horse-erythrocytes","display_name":"horse erythrocytes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/murine-myeloma-cells","display_name":"murine myeloma cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/complement-dependent-cytotoxicity","display_name":"complement-dependent cytotoxicity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/passive-immunotherapy","display_name":"passive immunotherapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/igg1-antibodies","display_name":"IgG1 antibodies","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.8845643401145935},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8734097480773926},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.8348599672317505},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7484728097915649},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5874642729759216},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5769807696342468},{"id":"https://openalex.org/C2777726029","wikidata":"https://www.wikidata.org/wiki/Q21114926","display_name":"Complement-dependent cytotoxicity","level":5,"score":0.5432149171829224},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5205634236335754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42294031381607056},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.410221129655838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39536261558532715},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35474061965942383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2671782374382019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12532681226730347},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/153685902321043990","doi":"https://doi.org/10.1089/153685902321043990","is_oa":false,"landing_page_url":"https://doi.org/10.1089/153685902321043990","pdf_url":null,"source":{"id":"https://openalex.org/S199469938","display_name":"Hybridoma and Hybridomics","issn_l":"1536-8599","issn":["1536-8599","1557-8097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma and Hybridomics","raw_type":"journal-article"},{"id":"pmid:12573110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12573110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma and hybridomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W3895122","https://openalex.org/W123313477","https://openalex.org/W1596598658","https://openalex.org/W1801816242","https://openalex.org/W1850381170","https://openalex.org/W1951179504","https://openalex.org/W1960710326","https://openalex.org/W1964983191","https://openalex.org/W1975186623","https://openalex.org/W1992441650","https://openalex.org/W1994911302","https://openalex.org/W1996685453","https://openalex.org/W2006106935","https://openalex.org/W2007854174","https://openalex.org/W2016292927","https://openalex.org/W2060294197","https://openalex.org/W2067844377","https://openalex.org/W2075021856","https://openalex.org/W2090032956","https://openalex.org/W2099847629","https://openalex.org/W2110134768","https://openalex.org/W2111838924","https://openalex.org/W2136892516","https://openalex.org/W2138348226","https://openalex.org/W2167531081","https://openalex.org/W2175766170","https://openalex.org/W2396146995","https://openalex.org/W2397858449"],"related_works":["https://openalex.org/W1237446364","https://openalex.org/W4308600702","https://openalex.org/W2065931804","https://openalex.org/W2956637914","https://openalex.org/W2047644188","https://openalex.org/W1964983191","https://openalex.org/W1518938995","https://openalex.org/W2515235946","https://openalex.org/W2015784141","https://openalex.org/W64848736"],"abstract_inverted_index":{"The":[0,79],"14F7":[1,39,60,122],"monoclonal":[2],"antibody":[3,8],"(MAb)":[4],"is":[5,28],"an":[6],"IgG(1)":[7],"that":[9,25,30],"reacts":[10],"specifically":[11,31],"with":[12,16,121,135],"GM3":[13,45],"(NeuGc)":[14],"and":[15,52,69,106,109],"tissue":[17],"sections":[18],"of":[19,38,59,86,97,112],"human":[20],"tumors.":[21],"We":[22],"demonstrated":[23],"here":[24],"this":[26,87],"MAb":[27,40,61,88,107,123],"agglutinin":[29],"agglutinated":[32],"horse":[33],"erythrocytes.":[34],"Additionally,":[35],"the":[36,75,84,92,104,110,113,118,131],"capacity":[37],"to":[41,64,89,130],"mediate":[42],"cytotoxicity":[43,67,72,100],"against":[44,74],"(NeuGc)-positive":[46],"murine":[47,76],"myeloma":[48,77],"cells,":[49],"in":[50,53],"vitro":[51],"vivo,":[54,117],"was":[55,83,101],"evaluated.":[56],"High":[57],"concentrations":[58],"were":[62],"needed":[63],"induce":[65],"complement-dependent":[66],"(CDC)":[68],"antibody-dependent":[70],"cell-mediated":[71],"(ADCC)":[73],"cells.":[78,115],"most":[80],"relevant":[81],"finding":[82],"ability":[85],"directly":[90],"kill":[91],"target":[93,114],"cells":[94],"without":[95],"participation":[96],"complement.":[98],"This":[99],"dependent":[102],"on":[103],"temperature":[105],"concentration":[108],"number":[111],"In":[116],"passive":[119],"treatment":[120],"produced":[124],"a":[125],"strong":[126],"anti-tumor":[127],"activity,":[128],"similar":[129],"anti-tumoral":[132],"response":[133],"obtained":[134],"standard":[136],"chemotherapy":[137],"treatment.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
