{"id":"https://openalex.org/W1997256256","doi":"https://doi.org/10.1165/ajrcmb/5.1.34","title":"Thrombin Enhances Lung Fibroblast Proliferation in Bleomycin-induced Pulmonary Fibrosis","display_name":"Thrombin Enhances Lung Fibroblast Proliferation in Bleomycin-induced Pulmonary Fibrosis","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1997256256","doi":"https://doi.org/10.1165/ajrcmb/5.1.34","mag":"1997256256","pmid":"https://pubmed.ncbi.nlm.nih.gov/1715176"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb/5.1.34","doi":"https://doi.org/10.1165/ajrcmb/5.1.34","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb/5.1.34","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080826692","display_name":"Kenji Tani","orcid":"https://orcid.org/0000-0001-5822-710X","observed_orcids":["https://orcid.org/0000-0001-5822-710X"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Tani","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112134885","display_name":"Susumu Yasuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Yasuoka","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015710166","display_name":"Fumitaka Ogushi","orcid":"https://orcid.org/0000-0003-3525-3457","observed_orcids":["https://orcid.org/0000-0003-3525-3457"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumitaka Ogushi","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kanji Asada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanji Asada","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028929027","display_name":"Kenji Fujisawa","orcid":"https://orcid.org/0000-0001-8720-6906","observed_orcids":["https://orcid.org/0000-0001-8720-6906"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Fujisawa","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112167868","display_name":"Toshio Ozaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Ozaki","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111451973","display_name":"Nobuya Sano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuya Sano","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086172496","display_name":"Takeshi Ogura","orcid":"https://orcid.org/0000-0003-2916-6568","observed_orcids":["https://orcid.org/0000-0003-2916-6568"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Ogura","raw_affiliation_strings":["Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and Second Department of Pathology, School of Medicine, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080826692"],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":null,"apc_paid":null,"fwci":4.3701,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.94418362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"34","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/thrombin-inhibitors","display_name":"thrombin inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hirudin","display_name":"hirudin","score":0.984000027179718},{"id":"https://openalex.org/keywords/alpha1-proteinase-inhibitor","display_name":"alpha 1-proteinase inhibitor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7794197201728821},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7722533345222473},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7124625444412231},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.6496999263763428},{"id":"https://openalex.org/C2778271848","wikidata":"https://www.wikidata.org/wiki/Q386715","display_name":"Hirudin","level":4,"score":0.5516435503959656},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5287135243415833},{"id":"https://openalex.org/C2776710957","wikidata":"https://www.wikidata.org/wiki/Q5280395","display_name":"Direct thrombin inhibitor","level":5,"score":0.5090603232383728},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.47896578907966614},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.4329107403755188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4307454228401184},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.42975395917892456},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4271894693374634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41489747166633606},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3620550334453583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3329482674598694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3299030065536499},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21489134430885315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10320469737052917},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09598475694656372},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000645","descriptor_name":"Ammonium Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1165/ajrcmb/5.1.34","doi":"https://doi.org/10.1165/ajrcmb/5.1.34","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb/5.1.34","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:1715176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1715176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W84467775","https://openalex.org/W302054957","https://openalex.org/W948817926","https://openalex.org/W1746577773","https://openalex.org/W1775749144","https://openalex.org/W1880873233","https://openalex.org/W1907990126","https://openalex.org/W1972637257","https://openalex.org/W1988878944","https://openalex.org/W2003817454","https://openalex.org/W2005101822","https://openalex.org/W2013547341","https://openalex.org/W2020910725","https://openalex.org/W2025233341","https://openalex.org/W2025939139","https://openalex.org/W2035307463","https://openalex.org/W2046027264","https://openalex.org/W2054287558","https://openalex.org/W2059777229","https://openalex.org/W2060297306","https://openalex.org/W2066262964","https://openalex.org/W2068123131","https://openalex.org/W2089468771","https://openalex.org/W2099780759","https://openalex.org/W2109284143","https://openalex.org/W2111803376","https://openalex.org/W2125059344","https://openalex.org/W2414699566"],"related_works":["https://openalex.org/W37345603","https://openalex.org/W1570214505","https://openalex.org/W2596958471","https://openalex.org/W2773554636","https://openalex.org/W2174210430","https://openalex.org/W2136539876","https://openalex.org/W2312869006","https://openalex.org/W7214218667","https://openalex.org/W2304246175","https://openalex.org/W4240275817"],"abstract_inverted_index":{"To":[0],"clarify":[1],"the":[2,10,22,61,74,80,97,114,160,170,173,182,188,199,207,210],"role":[3],"of":[4,12,24,49,113,163,181,190,198,209],"thrombin":[5,25,67,94,131,148,165,183,222],"in":[6,15,32,79,96,152,172,187,195,227,235],"fibroblast":[7,28,230],"growth":[8,231],"and":[9,56,60,69,106,141,154,232],"development":[11],"pulmonary":[13,233],"fibrosis":[14,234],"bleomycin-induced":[16,236],"interstitial":[17,237],"lung":[18,238],"disease,":[19],"we":[20],"examined":[21],"relationship":[23],"activity":[26,30,68,95,171,184],"to":[27,192,221],"growth-stimulating":[29],"(FGA)":[31],"bronchoalveolar":[33],"lavage":[34],"(BAL)":[35],"fluid":[36,63,82,99,116,212],"from":[37,83,117,213],"bleomycin-treated":[38,92,118,214],"rats.":[39],"Male":[40],"Wistar":[41],"rats":[42,84,119,215],"were":[43],"given":[44],"a":[45],"single":[46],"intratracheal":[47],"injection":[48],"bleomycin,":[50],"BAL":[51,62,81,98,115,174,211],"was":[52,64,77,100,123,157,185,201,216],"performed":[53],"2,":[54],"6,":[55],"15":[57],"days":[58],"later,":[59],"assayed":[65],"for":[66,229],"FGA.":[70],"Higher":[71],"FGA":[72,112,151,156,200,208],"than":[73],"control":[75],"value":[76],"detected":[78],"on":[85,103,108,120],"day":[86,104,109,121],"6":[87,122],"after":[88],"bleomycin":[89],"administration.":[90],"In":[91,143],"rats,":[93],"significantly":[101,124],"elevated":[102],"2":[105],"maximal":[107],"6.":[110],"The":[111],"decreased":[125],"by":[126,159],"its":[127,155],"treatment":[128],"with":[129],"various":[130],"inhibitors,":[132],"such":[133],"as":[134,167],"alpha":[135],"1-protease":[136],"inhibitor,":[137],"antithrombin":[138],"III,":[139],"hirudin,":[140],"MD-805.":[142],"our":[144],"assay,":[145],"purified":[146],"rat":[147],"also":[149],"showed":[150],"vitro,":[153],"inhibited":[158],"same":[161],"concentrations":[162],"these":[164],"inhibitors":[166],"those":[168],"inhibiting":[169],"fluid.":[175],"On":[176],"ammonium":[177],"sulfate":[178],"fractionation,":[179],"most":[180,197],"recovered":[186],"fraction":[189],"35":[191],"50%":[193],"saturation":[194],"which":[196],"detected.":[202],"These":[203],"results":[204],"suggest":[205],"that":[206],"at":[217,225],"least":[218,226],"partly":[219],"due":[220],"is":[223],"responsible,":[224],"part,":[228],"disease.":[239]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}