{"id":"https://openalex.org/W1997249468","doi":"https://doi.org/10.1016/j.jalz.2005.06.079","title":"[P\u2010017]: Clinical proteomics to diagnose Alzheimer's disease","display_name":"[P\u2010017]: Clinical proteomics to diagnose Alzheimer's disease","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W1997249468","doi":"https://doi.org/10.1016/j.jalz.2005.06.079","mag":"1997249468"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2005.06.079","doi":"https://doi.org/10.1016/j.jalz.2005.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2005.06.079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2005.06.079","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2005.06.079","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110177064","display_name":"Dwight C. German","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight C. German","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054216133","display_name":"Harold R. Garner","orcid":"https://orcid.org/0000-0001-5359-5990","observed_orcids":["https://orcid.org/0000-0001-5359-5990"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold R. Garner","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029617270","display_name":"Ramon R. Diaz-Arrastia","orcid":"https://orcid.org/0000-0001-6051-3594","observed_orcids":["https://orcid.org/0000-0001-6051-3594"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramon Diaz-Arrastia","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004676250","display_name":"Animesh Nandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Animesh Nandi","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110200041","display_name":"Prem Gurnani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prem Gurnani","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056323628","display_name":"Carol B. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Moore","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108810184","display_name":"Kevin P. Rosenblatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Rosenblatt","raw_affiliation_strings":["UT Southwestern Medical School, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical School, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10181582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1S_Part_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.3865000009536743,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-protein-profile","display_name":"serum protein profile","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7002031803131104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6496565341949463},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6139655113220215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.575936496257782},{"id":"https://openalex.org/C2994587664","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein chip","level":2,"score":0.5550068616867065},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.547717809677124},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44374826550483704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4081839323043823},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40726664662361145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3782919943332672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.223634272813797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10363498330116272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2005.06.079","doi":"https://doi.org/10.1016/j.jalz.2005.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2005.06.079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2005.06.079","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2005.06.079","doi":"https://doi.org/10.1016/j.jalz.2005.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2005.06.079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2005.06.079","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997249468.pdf","grobid_xml":"https://content.openalex.org/works/W1997249468.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027296514","https://openalex.org/W2388717657","https://openalex.org/W2128462285","https://openalex.org/W2620434301","https://openalex.org/W804942306","https://openalex.org/W2128987855","https://openalex.org/W2945300267","https://openalex.org/W2897143291","https://openalex.org/W1970673364","https://openalex.org/W2918874992"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,318],"(AD)":[2],"is":[3,49,61,75],"the":[4,13,20,28,42,69,90,103,110,113,118,150,186,193,230,238,248,280,296,309,317],"most":[5],"common":[6],"neurological":[7],"disorder":[8],"responsible":[9],"for":[10,185,237,262,305],"dementia":[11],"in":[12,102,203,282],"elderly":[14],"population.":[15],"While":[16],"research":[17],"efforts":[18],"over":[19],"past":[21],"decade":[22],"have":[23,36,121,139,234,256],"increased":[24],"our":[25],"knowledge":[26],"about":[27],"pathogenesis":[29],"of":[30,46,63,112,152,179,188,190,198,241,259,298,302,316],"AD,":[31,131],"we":[32,53,255,277],"still":[33],"do":[34],"not":[35],"a":[37,56,167,272,303],"simple":[38],"test":[39],"to":[40,50,81,108,149,158,228,291],"identify":[41],"disease.":[43],"The":[44,212,300],"goal":[45],"this":[47,204],"project":[48],"determine":[51],"whether":[52],"can":[54,182,215],"detect":[55],"serum":[57,67,70,104,123,181,239,246,249],"protein":[58,213,231],"profile":[59],"that":[60,79,86,233],"predictive":[62],"AD":[64,162,306],"using":[65,265],"raw":[66,245],"and/or":[68],"albumin":[71,250],"fraction.":[72],"Clinical":[73],"proteomics":[74],"an":[76],"emerging":[77],"field":[78],"promises":[80],"provide":[82],"unique":[83],"clinical":[84],"tools":[85],"may":[87],"dramatically":[88],"revolutionize":[89],"way":[91],"human":[92,180,242,253],"diseases":[93],"are":[94,105],"detected,":[95],"treated,":[96],"and":[97,132,144,163,210,247,269,285,288,312],"clinically":[98,128],"managed.":[99],"Proteins":[100],"present":[101],"now":[106],"believed":[107],"reflect":[109],"status":[111],"various":[114],"tissues":[115],"perfused":[116],"by":[117],"blood.":[119],"We":[120],"collected":[122],"samples":[124],"taken":[125],"from":[126,252],"patients":[127],"diagnosed":[129],"with":[130,142,160,219],"age-matched":[133],"normal":[134],"control":[135],"subjects.":[136],"Both":[137],"groups":[138,147],"been":[140,275],"examined":[141],"MRI":[143],"divided":[145],"into":[146],"according":[148],"degree":[151],"white":[153],"matter":[154],"damage":[155],"(from":[156],"severe":[157],"none),":[159],"30":[161],"41":[164],"controls.":[165],"Using":[166,244],"new":[168],"technique":[169],"called":[170],"SELDI-MS":[171],"(surface":[172],"enhanced":[173],"laser":[174],"desorption/ionization-mass":[175],"spectrometry),":[176],"minute":[177],"amounts":[178],"be":[183,201,217,226],"analyzed":[184],"measurement":[187],"thousands":[189],"proteins":[191],"at":[192],"same":[194],"time.":[195],"Three":[196],"types":[197],"instruments":[199],"will":[200,225,278,307],"employed":[202],"study:":[205],"SELDI":[206],"time-of-flight":[207],"(TOF),":[208],"SELDI-qTOF,":[209],"MALDI-TOF.":[211],"pattern":[214],"then":[216,286],"evaluated":[218],"special":[220],"computer":[221],"algorithms.":[222],"Bioinfomatic":[223],"software":[224],"used":[227],"analyze":[229],"profiles":[232],"proven":[235],"useful":[236],"diagnosis":[240],"cancers.":[243],"fraction":[251],"blood":[254],"detected":[257],"hundreds":[258],"protein/peptide":[260],"peaks":[261],"each":[263],"sample":[264],"Ciphergen":[266],"chips":[267],"(CM10":[268],"IMAC).":[270],"Once":[271],"bio-signature":[273,304],"has":[274],"developed,":[276],"validate":[279],"biomarkers":[281],"blinded":[283],"studies":[284],"enrich/purify":[287],"sequence":[289],"them,":[290],"potentially":[292],"shed":[293],"light":[294],"on":[295],"pathophysiology":[297],"AD.":[299],"identification":[301],"enable":[308],"early":[310,314],"detection":[311],"possible":[313],"treatment":[315],"before":[319],"significant":[320],"neurodegeneration":[321]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
