{"id":"https://openalex.org/W1997237244","doi":"https://doi.org/10.1507/endocrj1954.33.875","title":"Plasma disappearance half-time and metabolic clearance rate of exogenous human growth hormone-releasing hormone-(1-44)-NH2 in normal subjects.","display_name":"Plasma disappearance half-time and metabolic clearance rate of exogenous human growth hormone-releasing hormone-(1-44)-NH2 in normal subjects.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W1997237244","doi":"https://doi.org/10.1507/endocrj1954.33.875","mag":"1997237244","pmid":"https://pubmed.ncbi.nlm.nih.gov/3107967"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj1954.33.875","doi":"https://doi.org/10.1507/endocrj1954.33.875","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.33.875","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/33/6/33_6_875/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1954/33/6/33_6_875/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052414377","display_name":"Yasuhiko Okimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YASUHIKO OKIMURA","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113653169","display_name":"Kazuo Chihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUO CHIHARA","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032983935","display_name":"Hiromi Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROMI ABE","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068859334","display_name":"Hidesuke Kaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDESUKE KAJI","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113731800","display_name":"Hitoshi Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HITOSHI KODAMA","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401460","display_name":"Tetsuya Kita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TETSUYA KITA","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608390","display_name":"YOICHI KASHIO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOICHI KASHIO","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105417933","display_name":"Takuo Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKUO FUJITA","raw_affiliation_strings":["Third Division, Department of Medicine, Kobe University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of Medicine, Kobe University School of Medicine","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.08491947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"6","first_page":"875","last_page":"881"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.9290000200271606},{"id":"https://openalex.org/keywords/metabolic-clearance-rate","display_name":"metabolic clearance rate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9300000071525574},{"id":"https://openalex.org/keywords/biexponential-elimination","display_name":"biexponential elimination","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hypothalamic-hormones","display_name":"hypothalamic hormones","score":0.7689999938011169},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7153682708740234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6791390180587769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5987569689750671},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5268025398254395},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5263102054595947},{"id":"https://openalex.org/C2781042741","wikidata":"https://www.wikidata.org/wiki/Q409489","display_name":"Growth hormone\u2013releasing hormone","level":4,"score":0.49468228220939636},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.45883458852767944},{"id":"https://openalex.org/C3020190219","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous bolus","level":2,"score":0.4421462416648865},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.25988560914993286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19968420267105103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13645079731941223}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj1954.33.875","doi":"https://doi.org/10.1507/endocrj1954.33.875","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.33.875","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/33/6/33_6_875/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},{"id":"pmid:3107967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3107967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia japonica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj1954.33.875","doi":"https://doi.org/10.1507/endocrj1954.33.875","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.33.875","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/33/6/33_6_875/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997237244.pdf","grobid_xml":"https://content.openalex.org/works/W1997237244.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1974136631","https://openalex.org/W2003264590","https://openalex.org/W2004949005","https://openalex.org/W2063587143","https://openalex.org/W2066102305","https://openalex.org/W2066694892","https://openalex.org/W2077181804","https://openalex.org/W2080185465","https://openalex.org/W2087526401","https://openalex.org/W2093189833"],"related_works":["https://openalex.org/W2078109912","https://openalex.org/W2066102305","https://openalex.org/W7099972173","https://openalex.org/W7097401740","https://openalex.org/W1993219960","https://openalex.org/W1984199896","https://openalex.org/W2171970407","https://openalex.org/W1983717696","https://openalex.org/W2010070224","https://openalex.org/W2036147787"],"abstract_inverted_index":{"By":[0],"means":[1],"of":[2,16,27,41,49,68,83,94,96,106,115,125,135,143],"human":[3,138],"growth":[4],"hormone-releasing":[5],"hormone":[6],"(hGHRH)-RIA":[7],"using":[8],"an":[9,37],"antiserum":[10],"directed":[11],"toward":[12],"the":[13,18,107,123,151],"C-terminal":[14],"region":[15],"hGHRH-(1-44)-NH2,":[17],"plasma":[19,52,108,139,153],"disappearance":[20,48],"half-time":[21],"and":[22,63,72],"metabolic":[23,65],"clearance":[24,134],"rate":[25],"(MCR)":[26],"immuoreactive":[28],"hGHRH":[29,136,157],"(IR-hGHRH)":[30],"were":[31],"examined":[32,128],"in":[33,148,159],"normal":[34],"subjects":[35],"after":[36,122,156],"iv":[38],"bolus":[39],"injection":[40,124,158],"synthetic":[42],"hGHRH-(1-44)-NH2":[43,116,126],"(1":[44],"microgram/kg":[45],"BW).":[46],"The":[47,81,92,103],"IR-hGHRH":[50,84,97,109],"from":[51,113,137],"was":[53,85,98,110],"characterized":[54],"by":[55,129],"a":[56],"biexponential":[57],"decay":[58],"curve,":[59],"with":[60],"initial":[61],"distribution":[62,95],"subsequent":[64],"t1/2":[66],"value":[67],"5.0":[69],"+/-":[70,74,78,87,100],"1.0":[71],"29.6":[73],"5.4":[75],"min":[76,121],"(mean":[77],"SE),":[79],"respectively.":[80],"MCR":[82],"6.1":[86],"1.2":[88],"ml/min":[89],"X":[90],"kg.":[91],"volume":[93],"3.3":[99],"0.4":[101],"liters.":[102],"molecular":[104],"size":[105],"not":[111],"different":[112],"that":[114,142],"for":[117],"at":[118],"least":[119],"90":[120],"when":[127],"gel-filtration":[130],"chromatography.":[131],"This":[132],"prolonged":[133],"relative":[140],"to":[141],"other":[144],"hypothalamic":[145],"hormones":[146],"may":[147],"part":[149],"explain":[150],"sustained":[152],"GH":[154],"rises":[155],"man.":[160]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
