{"id":"https://openalex.org/W1997229649","doi":"https://doi.org/10.1021/bi8015789","title":"15N{31P} REDOR NMR Studies of the Binding of Phosphonate Reaction Intermediate Analogues to Saccharomyces cerevisiae Lumazine Synthase","display_name":"15N{31P} REDOR NMR Studies of the Binding of Phosphonate Reaction Intermediate Analogues to Saccharomyces cerevisiae Lumazine Synthase","publication_year":2008,"publication_date":"2008-12-03","ids":{"openalex":"https://openalex.org/W1997229649","doi":"https://doi.org/10.1021/bi8015789","mag":"1997229649","pmid":"https://pubmed.ncbi.nlm.nih.gov/19117095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630582"},"language":"en","primary_location":{"id":"doi:10.1021/bi8015789","doi":"https://doi.org/10.1021/bi8015789","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8015789","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057468033","display_name":"Tsyr\u2010Yan Yu","orcid":"https://orcid.org/0000-0001-7051-4769","observed_orcids":["https://orcid.org/0000-0001-7051-4769"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tsyr-Yan Yu","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert D. O\u2019Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Robert D. O\u2019Connor","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043057991","display_name":"Astrid C. Sivertsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Astrid C. Sivertsen","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040510414","display_name":"Colby Chiauzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Colby Chiauzzi","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088077790","display_name":"Barbara Poliks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Barbara Poliks","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006304159","display_name":"Markus J. Fischer","orcid":"https://orcid.org/0000-0001-7243-4199","observed_orcids":["https://orcid.org/0000-0001-7243-4199"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Markus Fischer","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068798153","display_name":"Adelbert Bacher","orcid":"https://orcid.org/0000-0001-5174-4139","observed_orcids":["https://orcid.org/0000-0001-5174-4139"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Adelbert Bacher","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070327668","display_name":"Ilka Haase","orcid":"https://orcid.org/0000-0001-8527-0461","observed_orcids":["https://orcid.org/0000-0001-8527-0461"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ilka Haase","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025438490","display_name":"Mark Cushman","orcid":"https://orcid.org/0000-0002-0152-5891","observed_orcids":["https://orcid.org/0000-0002-0152-5891"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Mark Cushman","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103146642","display_name":"Jacob Schaefer","orcid":"https://orcid.org/0000-0002-7544-6408","observed_orcids":["https://orcid.org/0000-0002-7544-6408","https://orcid.org/0009-0008-4979-9833"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Jacob Schaefer","raw_affiliation_strings":["Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington University, St. Louis, Missouri 63130, Department of Physics, State University of New York at Binghamton, Binghamton, New York 13902, Institute of Food Chemistry, Universit\u00e4t Hamburg, Grindelallee 117, D-20146 Hamburg, Germany, Lehrstuhl f\u00fcr Organische Chemie and Biochemie, Technische Universit\u00e4t M\u00fcnchen, D-85747 Garching, Germany, and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West","institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025438490","https://openalex.org/A5103146642"],"corresponding_institution_ids":["https://openalex.org/I123946342","https://openalex.org/I159176309","https://openalex.org/I204465549","https://openalex.org/I62916508"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6811,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60938119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"52","first_page":"13942","last_page":"13951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lumazine-synthase","display_name":"lumazine synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/riboflavin-biosynthesis","display_name":"riboflavin biosynthesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/enzyme-ligand-binding","display_name":"enzyme-ligand binding","score":0.7160000205039978},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2777626080","wikidata":"https://www.wikidata.org/wiki/Q422733","display_name":"Phosphonate","level":2,"score":0.849750816822052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6851918697357178},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6353311538696289},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5735470652580261},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4431537091732025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24042871594429016},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.21832820773124695}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010759","descriptor_name":"Phosphorus Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi8015789","doi":"https://doi.org/10.1021/bi8015789","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8015789","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19117095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19117095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2630582","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630582","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.690.8230","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.690.8230","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630582/pdf/nihms-86613.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2630582","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630582","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1495202843","display_name":null,"funder_award_id":"EB001964","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2284484778","display_name":"Protein Binding Sites by REDOR NMR","funder_award_id":"R01EB001964","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4233561887","display_name":"Ligands for Probing the Active Site of Lumazine Synthase","funder_award_id":"R01GM051469","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6427651337","display_name":null,"funder_award_id":"GM 51469","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W186810952","https://openalex.org/W1039779313","https://openalex.org/W1512810258","https://openalex.org/W1964223660","https://openalex.org/W1973957927","https://openalex.org/W1974891981","https://openalex.org/W1976499671","https://openalex.org/W1979002358","https://openalex.org/W1980081562","https://openalex.org/W1980532193","https://openalex.org/W1984112228","https://openalex.org/W1991659634","https://openalex.org/W1994896583","https://openalex.org/W2008517160","https://openalex.org/W2018573392","https://openalex.org/W2020890335","https://openalex.org/W2026978960","https://openalex.org/W2031427361","https://openalex.org/W2042258122","https://openalex.org/W2046608743","https://openalex.org/W2061148513","https://openalex.org/W2067133614","https://openalex.org/W2070787653","https://openalex.org/W2074896088","https://openalex.org/W2084786642","https://openalex.org/W2089961627","https://openalex.org/W2096712606","https://openalex.org/W2103723759","https://openalex.org/W2107029002","https://openalex.org/W2126865613","https://openalex.org/W2146048807","https://openalex.org/W2151060424","https://openalex.org/W2158534713","https://openalex.org/W2171881772","https://openalex.org/W2208194134","https://openalex.org/W2402281020","https://openalex.org/W2414489610","https://openalex.org/W2414805111","https://openalex.org/W2425792272","https://openalex.org/W2466841613","https://openalex.org/W2951888752","https://openalex.org/W4323285025"],"related_works":["https://openalex.org/W7095552354","https://openalex.org/W2951888752","https://openalex.org/W1980532193","https://openalex.org/W2049661050","https://openalex.org/W2026119781","https://openalex.org/W7134667977","https://openalex.org/W1993865672","https://openalex.org/W2146048807","https://openalex.org/W2070787653","https://openalex.org/W2012820507"],"abstract_inverted_index":{"Lumazine":[0],"synthase":[1,50],"catalyzes":[2],"the":[3,14,61,65,68,88,95,100,116,123,130,136,142],"reaction":[4,22,42],"of":[5,18,26,37,64,72,92,94,105,115,125],"5-amino-6-D-ribitylamino-2,4(1H,3H)-pyrimidinedione(1)":[6],"with":[7,87,99,135],"(S)-3,4-dihydroxybutanone":[8],"4-phosphate":[9],"(2)":[10],"to":[11,46,67],"afford":[12],"6,7-dimethyl-8-D-ribityllumazine(3),":[13],"immediate":[15],"biosynthetic":[16],"precursor":[17],"riboflavin.":[19],"The":[20,32,110],"overall":[21],"implies":[23],"a":[24,103],"series":[25,104],"intermediates":[27],"that":[28],"are":[29],"incompletely":[30],"understood.":[31],"15N{31P}":[33],"REDOR":[34],"NMR":[35],"spectra":[36],"three":[38],"metabolically":[39],"stable":[40],"phosphonate":[41],"intermediate":[43,96],"analogues":[44,97],"complexed":[45,98],"Saccharomyces":[47],"cereVisiae":[48],"lumazine":[49],"have":[51,78],"been":[52,79],"obtained":[53],"at":[54],"7":[55],"and":[56,76],"12":[57],"T.":[58],"Distances":[59],"from":[60,129],"phosphorus":[62],"atoms":[63],"ligands":[66],"side":[69,118],"chain":[70],"nitrogens":[71],"Lys92,":[73],"His97,":[74],"Arg136,":[75],"His148":[77],"determined.":[80],"These":[81],"distances":[82],"were":[83],"used":[84],"in":[85,102,132],"combination":[86],"X-ray":[89],"crystal":[90],"coordinates":[91],"one":[93,133],"enzyme":[101],"distance-restrained":[106],"molecular":[107],"dynamics":[108],"simulations.":[109],"resulting":[111],"models":[112],"indicate":[113],"mobility":[114],"Lys92":[117],"chain,":[119],"which":[120],"could":[121],"facilitate":[122],"exchange":[124],"inorganic":[126],"phosphate":[127],"eliminated":[128],"substrate":[131,139],"reaction,":[134],"organic":[137],"phosphate-containing":[138],"necessary":[140],"for":[141],"next":[143],"reaction.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}