{"id":"https://openalex.org/W1997226877","doi":"https://doi.org/10.1371/journal.pone.0030509","title":"Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia","display_name":"Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia","publication_year":2012,"publication_date":"2012-02-16","ids":{"openalex":"https://openalex.org/W1997226877","doi":"https://doi.org/10.1371/journal.pone.0030509","mag":"1997226877","pmid":"https://pubmed.ncbi.nlm.nih.gov/22359542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3281025"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0030509","doi":"https://doi.org/10.1371/journal.pone.0030509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030509","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030509&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030509&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020086487","display_name":"Michele L. Scotti","orcid":"https://orcid.org/0000-0002-4696-1611","observed_orcids":["https://orcid.org/0000-0002-4696-1611"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele L. Scotti","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kristin E. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin E. Smith","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","Mayo Clinic Jacksonville (FL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"Mayo Clinic Jacksonville (FL)","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001481592","display_name":"Amanda Saravia-Butler","orcid":"https://orcid.org/0000-0001-7505-2743","observed_orcids":["https://orcid.org/0000-0001-7505-2743"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda M. Butler","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","Mayo Clinic Jacksonville (FL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"Mayo Clinic Jacksonville (FL)","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088822347","display_name":"Shelly R. Calcagno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelly R. Calcagno","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","Mayo Clinic Jacksonville (FL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"Mayo Clinic Jacksonville (FL)","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054373028","display_name":"Howard C. Crawford","orcid":"https://orcid.org/0000-0001-9360-3019","observed_orcids":["https://orcid.org/0000-0001-9360-3019"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard C. Crawford","raw_affiliation_strings":["Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067987771","display_name":"Michael Leitges","orcid":"https://orcid.org/0000-0003-4203-6995","observed_orcids":["https://orcid.org/0000-0003-4203-6995"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Michael Leitges","raw_affiliation_strings":["Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway","University of Oslo#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"University of Oslo#TAB#","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081306238","display_name":"Alan P. Fields","orcid":"https://orcid.org/0000-0001-9529-0888","observed_orcids":["https://orcid.org/0000-0001-9529-0888"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P. Fields","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003409853","display_name":"Nicole R. Murray","orcid":"https://orcid.org/0000-0002-6833-8273","observed_orcids":["https://orcid.org/0000-0002-6833-8273"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole R. Murray","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003409853"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2645,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79014776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"2","first_page":"e30509","last_page":"e30509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c-iota","display_name":"PRKCI","score":0.984000027179718},{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7519999742507935},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.9580000042915344},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8899999856948853},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pancreatic-neoplasia","display_name":"pancreatic neoplasia","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pancreatic-epithelium","display_name":"pancreatic epithelium","score":0.6150000095367432},{"id":"https://openalex.org/keywords/pkc-inhibition","display_name":"PKC inhibition","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2909925829","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic Intraepithelial Neoplasia","level":5,"score":0.7946279048919678},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7203943729400635},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7165254950523376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6832201480865479},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4917660057544708},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.47430184483528137},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.450550377368927},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38523101806640625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3809051215648651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38081789016723633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3789525330066681},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3456820845603943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33194592595100403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3152112364768982},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20972341299057007},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000099293","descriptor_name":"Protein Kinase C-lambda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020783","descriptor_name":"Matrix Metalloproteinase 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061354","descriptor_name":"Acinar Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0030509","doi":"https://doi.org/10.1371/journal.pone.0030509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030509","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030509&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3281025","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3281025","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22359542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22359542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:999d12913e0544b8af1acb8fe7d27131","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/999d12913e0544b8af1acb8fe7d27131","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 2, p e30509 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/128695","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Protein_Kinase_C_Iota_Regulates_Pancreatic_Acinar_to_Ductal_Metaplasia/128695","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0030509","doi":"https://doi.org/10.1371/journal.pone.0030509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030509","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030509&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1185147035","display_name":"Protein Kinase C Signaling Mechanisms in Cancer","funder_award_id":"R01CA081436","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1655353241","display_name":null,"funder_award_id":"CA102701","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2075094911","display_name":null,"funder_award_id":"CA102701","funder_id":"https://openalex.org/F4320306143","funder_display_name":"Mayo Clinic"},{"id":"https://openalex.org/G5538709824","display_name":"ADAM17 in pancreatic cancer and pancreatitis","funder_award_id":"R01CA159222","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5583185491","display_name":"Mayo Clinic SPORE in Pancreatic Cancer","funder_award_id":"P50CA102701","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6099097669","display_name":null,"funder_award_id":"IA 52242","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8149169081","display_name":"Role of PKC iota in metaplasia and initiation of pancreatic cancer","funder_award_id":"R01CA140290","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G815598048","display_name":null,"funder_award_id":"P50 CA102701","funder_id":"https://openalex.org/F4320306143","funder_display_name":"Mayo Clinic"},{"id":"https://openalex.org/G9000146046","display_name":null,"funder_award_id":"CA102701","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320308851","display_name":"Lustgarten Foundation","ror":"https://ror.org/030635250"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997226877.pdf","grobid_xml":"https://content.openalex.org/works/W1997226877.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W62932861","https://openalex.org/W1547700789","https://openalex.org/W1589994366","https://openalex.org/W1675105744","https://openalex.org/W1966427973","https://openalex.org/W1980135491","https://openalex.org/W1982781304","https://openalex.org/W1983114685","https://openalex.org/W1987099302","https://openalex.org/W1991039898","https://openalex.org/W1991313250","https://openalex.org/W2001914338","https://openalex.org/W2019267635","https://openalex.org/W2042082068","https://openalex.org/W2043497705","https://openalex.org/W2056768114","https://openalex.org/W2058703787","https://openalex.org/W2061340775","https://openalex.org/W2064794660","https://openalex.org/W2066135299","https://openalex.org/W2067738832","https://openalex.org/W2071607446","https://openalex.org/W2084480556","https://openalex.org/W2088693506","https://openalex.org/W2105845694","https://openalex.org/W2110831371","https://openalex.org/W2111476336","https://openalex.org/W2115899458","https://openalex.org/W2118068705","https://openalex.org/W2123155461","https://openalex.org/W2130821995","https://openalex.org/W2132387165","https://openalex.org/W2135896412","https://openalex.org/W2140736039","https://openalex.org/W2144512179","https://openalex.org/W2148054025","https://openalex.org/W2158819616","https://openalex.org/W2164006717","https://openalex.org/W2165068298","https://openalex.org/W2170785598","https://openalex.org/W2418152404"],"related_works":["https://openalex.org/W7100158793","https://openalex.org/W2089174697","https://openalex.org/W2322371309","https://openalex.org/W2105845694","https://openalex.org/W4395666237","https://openalex.org/W7098267456","https://openalex.org/W2263865356","https://openalex.org/W2301319450","https://openalex.org/W2042988340","https://openalex.org/W4393096638"],"abstract_inverted_index":{"Pancreatic":[0],"acinar-to-ductal":[1],"metaplasia":[2,226],"(ADM)":[3],"is":[4,14,45,53,102,120,149,205,216],"associated":[5],"with":[6],"an":[7,206],"increased":[8],"risk":[9],"of":[10,18,24,61,76,85,131,161,170,209,221],"pancreatic":[11,19,34,50,62,78,81,89,108,124,157,210,224],"cancer":[12,51,63],"and":[13,52,59,80,94,106,110,135,155,159,166,176,179,212],"considered":[15],"a":[16,73,143,189,217],"precursor":[17],"ductal":[20,225],"adenocarcinoma.":[21],"Transgenic":[22],"expression":[23,69,175],"transforming":[25],"growth":[26,58],"factor":[27],"alpha":[28],"(TGF-\u03b1)":[29],"or":[30],"K-ras(G12D)":[31,86,119,222],"in":[32,38,48,72,91,104,114,126,139,152,185,223,227],"mouse":[33,74,107],"epithelium":[35],"induces":[36,195],"ADM":[37,79,90,109,125,158,184,196],"vivo.":[39,115,228],"Protein":[40],"kinase":[41],"C":[42],"iota":[43],"(PKC\u03b9)":[44],"highly":[46,150],"expressed":[47,151],"human":[49,105],"required":[54],"for":[55,97],"the":[56,95,132],"transformed":[57],"tumorigenesis":[60],"cells.":[64],"In":[65],"this":[66],"study,":[67],"PKC\u03b9":[68,101,148,162,171,204,215],"was":[70,99],"assessed":[71],"model":[75],"K-ras(G12D)-induced":[77,156,173],"cancer.":[82],"The":[83],"ability":[84],"to":[87,122],"induce":[88,123],"explant":[92,127],"culture,":[93,128],"requirement":[96],"PKC\u03b9,":[98],"investigated.":[100],"elevated":[103],"intraepithelial":[111],"neoplastic":[112],"lesions":[113],"We":[116],"demonstrate":[117],"that":[118,193,203,214],"sufficient":[121],"exhibiting":[129],"many":[130],"same":[133],"morphologic":[134],"biochemical":[136],"alterations":[137],"observed":[138],"TGF-\u03b1-induced":[140],"ADM,":[141],"including":[142],"dependence":[144],"on":[145],"Notch":[146,177,198],"activation.":[147,199],"both":[153],"TGF-\u03b1-":[154,165],"inhibition":[160],"significantly":[163],"reduces":[164],"K-ras(G12D)-mediated":[167,183],"ADM.":[168],"Inhibition":[169],"suppresses":[172],"MMP-7":[174,181],"activation,":[178],"exogenous":[180],"restores":[182],"PKC\u03b9-depleted":[186],"cells,":[187],"implicating":[188],"K-ras(G12D)-PKC\u03b9-MMP-7":[190],"signaling":[191],"axis":[192],"likely":[194],"through":[197],"Our":[200],"results":[201],"indicate":[202],"early":[207],"marker":[208],"neoplasia":[211],"suggest":[213],"potential":[218],"downstream":[219],"target":[220]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
