{"id":"https://openalex.org/W1997209154","doi":"https://doi.org/10.1016/j.neurol.2009.03.013","title":"Efficacit\u00e9 et tol\u00e9rance du cyclophosphamide dans le traitement de fond des formes progressives de la scl\u00e9rose en plaques","display_name":"Efficacit\u00e9 et tol\u00e9rance du cyclophosphamide dans le traitement de fond des formes progressives de la scl\u00e9rose en plaques","publication_year":2009,"publication_date":"2009-06-11","ids":{"openalex":"https://openalex.org/W1997209154","doi":"https://doi.org/10.1016/j.neurol.2009.03.013","mag":"1997209154","pmid":"https://pubmed.ncbi.nlm.nih.gov/19520407"},"language":"fr","primary_location":{"id":"doi:10.1016/j.neurol.2009.03.013","doi":"https://doi.org/10.1016/j.neurol.2009.03.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurol.2009.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S124451323","display_name":"Revue Neurologique","issn_l":"0035-3787","issn":["0035-3787","2213-0004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue Neurologique","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085210659","display_name":"El Hachmia Ait Ben Haddou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. Ait Ben Haddou","raw_affiliation_strings":["Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc. elaitbenha@yahoo.fr","Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc. elaitbenha@yahoo.fr","institution_ids":[]},{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111540255","display_name":"Ali Benomar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A. Benomar","raw_affiliation_strings":["Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022894428","display_name":"Samir Ahid","orcid":"https://orcid.org/0000-0002-7797-4722","observed_orcids":["https://orcid.org/0000-0002-7797-4722"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"S. Ahid","raw_affiliation_strings":["Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075534674","display_name":"H. Chatri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Chatri","raw_affiliation_strings":["Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013717082","display_name":"C. Slimani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Slimani","raw_affiliation_strings":["Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110088352","display_name":"Moulay Rachid El Hassani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hassani","raw_affiliation_strings":["Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063435284","display_name":"Kaoutar El Alaoui Taoussi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"K. El Alaoui Taoussi","raw_affiliation_strings":["Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082488041","display_name":"R\u00e9douane Abouqal","orcid":"https://orcid.org/0000-0002-6117-4341","observed_orcids":["https://orcid.org/0000-0002-6117-4341"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"R. Abouqal","raw_affiliation_strings":["Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche et des essais cliniques, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Laboratoire de biostatistique et de recherche clinique et \u00e9pid\u00e9miologique, facult\u00e9 de m\u00e9decine et de pharmacie, Rabat, Maroc","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004871974","display_name":"Mounir Yahyaoui","orcid":"https://orcid.org/0000-0001-5024-6592","observed_orcids":["https://orcid.org/0000-0001-5024-6592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Yahyaoui","raw_affiliation_strings":["Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie B et neurog\u00e9n\u00e9tique, h\u00f4pital des sp\u00e9cialit\u00e9s, Rabat, Maroc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085210659"],"corresponding_institution_ids":[],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.416,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65248485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"165","issue":"12","first_page":"1086","last_page":"1091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/progressive-multiple-sclerosis","display_name":"progressive multiple sclerosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/primary-progressive-multiple-sclerosis","display_name":"primary progressive multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/baseline-therapy","display_name":"baseline therapy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/edss-progression","display_name":"EDSS progression","score":0.6959999799728394},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.49000000953674316},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8479999899864197},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.744357168674469},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7257087826728821},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6138608455657959},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2273106575012207},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16306671500205994}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006233","descriptor_name":"Persons with Disabilities","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neurol.2009.03.013","doi":"https://doi.org/10.1016/j.neurol.2009.03.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurol.2009.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S124451323","display_name":"Revue Neurologique","issn_l":"0035-3787","issn":["0035-3787","2213-0004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue Neurologique","raw_type":"journal-article"},{"id":"pmid:19520407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19520407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue neurologique","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1493274582","https://openalex.org/W1535775842","https://openalex.org/W1963954204","https://openalex.org/W1969554567","https://openalex.org/W1972663088","https://openalex.org/W1998455368","https://openalex.org/W2012054969","https://openalex.org/W2018837615","https://openalex.org/W2022525996","https://openalex.org/W2030907857","https://openalex.org/W2035620823","https://openalex.org/W2040490702","https://openalex.org/W2046286355","https://openalex.org/W2047251742","https://openalex.org/W2051298001","https://openalex.org/W2060485000","https://openalex.org/W2105074531","https://openalex.org/W2105490558","https://openalex.org/W2112165124","https://openalex.org/W2130355701","https://openalex.org/W2131585698","https://openalex.org/W2139367012","https://openalex.org/W2140216003","https://openalex.org/W2142311493","https://openalex.org/W2144633544","https://openalex.org/W2150669424","https://openalex.org/W2155502276","https://openalex.org/W2165547142","https://openalex.org/W2168578994","https://openalex.org/W2169098250","https://openalex.org/W2340533542","https://openalex.org/W2419224547","https://openalex.org/W4210548604","https://openalex.org/W4240901768","https://openalex.org/W4252893551","https://openalex.org/W4313307391","https://openalex.org/W4317931319"],"related_works":["https://openalex.org/W2040947306","https://openalex.org/W1963954204","https://openalex.org/W7140182084","https://openalex.org/W2789301954","https://openalex.org/W2060485000","https://openalex.org/W7006234102","https://openalex.org/W4251700420","https://openalex.org/W7044411407","https://openalex.org/W2473980629","https://openalex.org/W2000792797"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
