{"id":"https://openalex.org/W1997205759","doi":"https://doi.org/10.1158/1538-7445.am2012-4730","title":"Abstract 4730: Inhibition of the p53-HDMX interaction sensitizes melanoma to chemotherapy","display_name":"Abstract 4730: Inhibition of the p53-HDMX interaction sensitizes melanoma to chemotherapy","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1997205759","doi":"https://doi.org/10.1158/1538-7445.am2012-4730","mag":"1997205759"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-4730","doi":"https://doi.org/10.1158/1538-7445.am2012-4730","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4730","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024787813","display_name":"Elisabeth A. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth A. Russell","raw_affiliation_strings":["1NCI, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017581020","display_name":"Agnieszka Gembarska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Agnieszka Gembarska","raw_affiliation_strings":["2KULeuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008853880","display_name":"Jean\u2010Christophe Marine","orcid":"https://orcid.org/0000-0003-2433-9837","observed_orcids":["https://orcid.org/0000-0003-2433-9837"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Christophe Marine","raw_affiliation_strings":["2KULeuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2KULeuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090162798","display_name":"Federico Bernal","orcid":"https://orcid.org/0000-0002-4667-5105","observed_orcids":["https://orcid.org/0000-0002-4667-5105"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federico Bernal","raw_affiliation_strings":["1NCI, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"4730","last_page":"4730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hdmx","display_name":"HDMX","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.6660000085830688},{"id":"https://openalex.org/keywords/nutlin-3","display_name":"Nutlin-3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.5950000286102295},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8009999990463257},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8276108503341675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6993809342384338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6775587797164917},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5354243516921997},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5287463665008545},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.501239538192749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4993782043457031},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.478385329246521},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46680453419685364},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3330031633377075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24623706936836243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21249711513519287},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12345361709594727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06858831644058228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-4730","doi":"https://doi.org/10.1158/1538-7445.am2012-4730","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4730","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046585589","https://openalex.org/W2138244274","https://openalex.org/W2063313554","https://openalex.org/W2103069797","https://openalex.org/W2955862491","https://openalex.org/W1969396454","https://openalex.org/W2590591064","https://openalex.org/W3100751285","https://openalex.org/W7111903635","https://openalex.org/W7100360501"],"abstract_inverted_index":{"Abstract":[0],"Melanoma":[1],"is":[2,13,18,167],"the":[3,44,63,98,107,141,187,192,195,199,234,239],"leading":[4],"cause":[5],"of":[6,29,39,56,75,89,111,144,194,201,209,233,238],"death":[7],"from":[8],"skin":[9],"disease":[10,36],"worldwide.":[11],"It":[12],"an":[14,127],"aggressive":[15],"cancer":[16],"that":[17,77,96,135,164],"often":[19],"resistant":[20],"to":[21,46,50,84,118,156,169,181],"conventional":[22,121],"chemotherapy":[23],"and":[24,37,70,150],"radiation-based":[25],"therapy.":[26],"The":[27,207],"combination":[28],"a":[30,72,136,174,214,217],"low":[31],"survival":[32],"rate":[33],"in":[34,87,101,205],"metastatic":[35,170,203,223],"lack":[38],"successful":[40],"treatment":[41,119,166,182],"options":[42],"underscores":[43],"need":[45],"elucidate":[47],"novel":[48],"methods":[49],"target":[51],"melanoma.":[52,92,224],"More":[53],"than":[54],"95%":[55],"human":[57,90,202],"melanomas":[58],"retain":[59],"wild":[60],"type":[61],"p53,":[62,79,112],"protein":[64],"responsible":[65],"for":[66,154,216,222,242],"maintaining":[67],"genomic":[68],"integrity;":[69],"HDMX,":[71],"negative":[73],"regulator":[74],"p53":[76,129,145,155,211],"neutralizes":[78],"has":[80],"recently":[81],"been":[82],"found":[83],"be":[85],"overexpressed":[86],"65%":[88],"cutaneous":[91],"These":[93],"features":[94],"suggest":[95],"targeting":[97],"p53-HDMX":[99,151,196],"interaction":[100],"melanoma":[102,116,171,180,204],"could":[103],"not":[104],"only":[105],"restore":[106],"tumor":[108],"suppressor":[109],"function":[110],"but":[113],"also":[114],"sensitize":[115],"cells":[117,172],"with":[120,183],"chemotherapeutic":[122],"agents":[123],"which":[124],"rely":[125],"on":[126,140],"intact":[128],"response.":[130],"We":[131],"have":[132],"previously":[133,218],"demonstrated":[134],"hydrocarbon-stapled":[137],"\u03b1-helix":[138],"based":[139],"transactivation":[142],"domain":[143],"(SAH-p53-8)":[146],"efficiently":[147],"disrupts":[148],"p53-HDM2":[149],"complexes":[152],"allowing":[153],"induce":[157],"apoptotic":[158],"cell":[159],"death.":[160],"Here,":[161],"we":[162],"show":[163],"SAH-p53-8":[165,178],"cytotoxic":[168],"by":[173],"p53-dependent":[175],"mechanism.":[176],"Additionally,":[177],"sensitizes":[179],"either":[184],"cisplatin":[185],"or":[186],"HDM2-specific":[188],"inhibitor":[189],"Nutlin-3.":[190],"Importantly,":[191],"inhibition":[193],"complex":[197],"arrests":[198],"growth":[200],"vivo.":[206],"restoration":[208],"functional":[210],"activity":[212],"provides":[213],"basis":[215],"unrecognized":[219],"targeted":[220],"therapy":[221],"Citation":[225],"Format:":[226],"{Authors}.":[227],"{Abstract":[228],"title}":[229],"[abstract].":[230],"In:":[231],"Proceedings":[232],"103rd":[235],"Annual":[236],"Meeting":[237],"American":[240],"Association":[241],"Cancer":[243,254],"Research;":[244],"2012":[245],"Mar":[246],"31-Apr":[247],"4;":[248],"Chicago,":[249],"IL.":[250],"Philadelphia":[251],"(PA):":[252],"AACR;":[253],"Res":[255],"2012;72(8":[256],"Suppl):Abstract":[257],"nr":[258],"4730.":[259],"doi:1538-7445.AM2012-4730":[260]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
