{"id":"https://openalex.org/W1997204206","doi":"https://doi.org/10.1016/s0009-8981(98)00049-7","title":"Sex differences and age-related changes in human serum aminopeptidase A activity","display_name":"Sex differences and age-related changes in human serum aminopeptidase A activity","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1997204206","doi":"https://doi.org/10.1016/s0009-8981(98)00049-7","mag":"1997204206","pmid":"https://pubmed.ncbi.nlm.nih.gov/9681597"},"language":"en","primary_location":{"id":"doi:10.1016/s0009-8981(98)00049-7","doi":"https://doi.org/10.1016/s0009-8981(98)00049-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-8981(98)00049-7","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052352950","display_name":"Jos\u00e9 Manuel Mart\u00ednez-Martos","orcid":"https://orcid.org/0000-0002-2950-5614","observed_orcids":["https://orcid.org/0000-0002-2950-5614"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M Mart\u0131\u0301nez","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002979930","display_name":"Isabel Prieto","orcid":"https://orcid.org/0000-0003-0624-9504","observed_orcids":["https://orcid.org/0000-0003-0624-9504"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Prieto","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034709965","display_name":"Mar\u00eda Jes\u00fas Ram\u00edrez-Exp\u00f3sito","orcid":"https://orcid.org/0000-0002-9379-203X","observed_orcids":["https://orcid.org/0000-0002-9379-203X"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u0131\u0301a J Ram\u0131\u0301rez","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055155293","display_name":"Marc de Gasparo","orcid":"https://orcid.org/0000-0002-1005-7866","observed_orcids":["https://orcid.org/0000-0002-1005-7866"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marc de Gasparo","raw_affiliation_strings":["Novartis Pharma, CH-4002, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, CH-4002, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029111914","display_name":"Francisco Hermoso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Hermoso","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jos\u00e9 M Arias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M Arias","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086129394","display_name":"Francisco Alba","orcid":"https://orcid.org/0000-0003-3325-5598","observed_orcids":["https://orcid.org/0000-0003-3325-5598"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Alba","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027294178","display_name":"Manuel R. Ram\u00edrez","orcid":"https://orcid.org/0000-0003-0332-6973","observed_orcids":["https://orcid.org/0000-0003-0332-6973"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Manuel Ram\u0131\u0301rez","raw_affiliation_strings":["Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Physiology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I191420491"]},{"raw_affiliation_string":"Unit of Physiology, University of Jae\u0301n, 23071 Jae\u0301n, Spain;","institution_ids":["https://openalex.org/I191420491"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027294178"],"corresponding_institution_ids":["https://openalex.org/I191420491"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.5012,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.83863273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"274","issue":"1","first_page":"53","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.2029999941587448,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminopeptidase-a","display_name":"aminopeptidase A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6869999766349792},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.7799999713897705},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.609000027179718},{"id":"https://openalex.org/keywords/development-biology","display_name":"development (biology)","score":0.7540000081062317},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.7519999742507935},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2780985610","wikidata":"https://www.wikidata.org/wiki/Q419527","display_name":"Aminopeptidase","level":4,"score":0.8320777416229248},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.8005499839782715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521388828754425},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5133406519889832},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48090672492980957},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45902639627456665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4531961679458618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29795926809310913},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.17974388599395752},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1758141815662384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17244195938110352},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043384","descriptor_name":"Glutamyl Aminopeptidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0009-8981(98)00049-7","doi":"https://doi.org/10.1016/s0009-8981(98)00049-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-8981(98)00049-7","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:9681597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9681597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W116919105","https://openalex.org/W1968226729","https://openalex.org/W1978280297","https://openalex.org/W1991333202","https://openalex.org/W2004683843","https://openalex.org/W2005779768","https://openalex.org/W2012130585","https://openalex.org/W2015141535","https://openalex.org/W2021775305","https://openalex.org/W2033902999","https://openalex.org/W2034562813","https://openalex.org/W2053954003","https://openalex.org/W2061463743","https://openalex.org/W2071138102","https://openalex.org/W2073529067","https://openalex.org/W2128635872","https://openalex.org/W2256547794","https://openalex.org/W2275895261","https://openalex.org/W2307814138","https://openalex.org/W2404372802","https://openalex.org/W2404589767","https://openalex.org/W2409815736","https://openalex.org/W2410693055","https://openalex.org/W2414061643","https://openalex.org/W2416597023","https://openalex.org/W2422556581","https://openalex.org/W2796286277"],"related_works":["https://openalex.org/W2187863006","https://openalex.org/W2075012592","https://openalex.org/W2021775305","https://openalex.org/W2062855572","https://openalex.org/W1993192052","https://openalex.org/W2585817411","https://openalex.org/W2422930672","https://openalex.org/W3002991770","https://openalex.org/W3003104515","https://openalex.org/W2009705035"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}