{"id":"https://openalex.org/W1997201791","doi":"https://doi.org/10.1002/ijc.10264","title":"Evidence for an age\u2010related influence of microsatellite instability on colorectal cancer survival","display_name":"Evidence for an age\u2010related influence of microsatellite instability on colorectal cancer survival","publication_year":2002,"publication_date":"2002-02-19","ids":{"openalex":"https://openalex.org/W1997201791","doi":"https://doi.org/10.1002/ijc.10264","mag":"1997201791","pmid":"https://pubmed.ncbi.nlm.nih.gov/11948461"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.10264","doi":"https://doi.org/10.1002/ijc.10264","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10264","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007530177","display_name":"Susan Mary Farrington","orcid":"https://orcid.org/0000-0001-5955-7389","observed_orcids":["https://orcid.org/0000-0001-5955-7389"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan M. Farrington","raw_affiliation_strings":["Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","MRC Human Genetics Unit, Edinburgh, United Kingdom","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"MRC Human Genetics Unit, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614"]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745643","display_name":"Aileen J. McKinley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aileen J. McKinley","raw_affiliation_strings":["Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112308971","display_name":"Andrew D. Carothers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew D. Carothers","raw_affiliation_strings":["MRC Human Genetics Unit, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Human Genetics Unit, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008612028","display_name":"Chris Cunningham","orcid":"https://orcid.org/0000-0002-8636-6577","observed_orcids":["https://orcid.org/0000-0002-8636-6577","https://orcid.org/0000-0003-2489-5745"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Cunningham","raw_affiliation_strings":["Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063620741","display_name":"Vivien J. Bubb","orcid":"https://orcid.org/0000-0003-2763-7004","observed_orcids":["https://orcid.org/0000-0003-2763-7004"]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vivien J. Bubb","raw_affiliation_strings":["Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085045412","display_name":"Linda Sharp","orcid":"https://orcid.org/0000-0001-9515-1722","observed_orcids":["https://orcid.org/0000-0001-9515-1722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Sharp","raw_affiliation_strings":["Information and Statistics Division, Scottish Health Service Common Services Agency, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information and Statistics Division, Scottish Health Service Common Services Agency, Edinburgh, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111633604","display_name":"Andrew H. Wyllie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew H. Wyllie","raw_affiliation_strings":["Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Laboratories, Department of Pathology, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016100282","display_name":"Malcolm G. Dunlop","orcid":"https://orcid.org/0000-0002-3033-5851","observed_orcids":["https://orcid.org/0000-0002-3033-5851"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Malcolm G. Dunlop","raw_affiliation_strings":["","Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","MRC Human Genetics Unit, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"MRC Human Genetics Unit, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016100282"],"corresponding_institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":4.8595,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.95372265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"98","issue":"6","first_page":"844","last_page":"850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mlh1","display_name":"MLH1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mucinous-tumors","display_name":"mucinous tumors","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dukes-stage","display_name":"Dukes stage","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cancer-surveillance","display_name":"cancer surveillance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.8961619138717651},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.7499912977218628},{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.66130131483078},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6415331363677979},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5880445241928101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5464249849319458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5432549118995667},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.5358072519302368},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5093179941177368},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48249268531799316},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4782087802886963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4539170563220978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29841211438179016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18999311327934265},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.18606603145599365},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.13202154636383057},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.11578446626663208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0773862898349762},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070957","descriptor_name":"MutL Protein Homolog 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002288","descriptor_name":"Adenocarcinoma, Mucinous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002288","descriptor_name":"Adenocarcinoma, Mucinous","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002288","descriptor_name":"Adenocarcinoma, Mucinous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.10264","doi":"https://doi.org/10.1002/ijc.10264","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.10264","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11948461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11948461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1499941079","https://openalex.org/W1516261157","https://openalex.org/W1534626339","https://openalex.org/W1967155906","https://openalex.org/W1967449511","https://openalex.org/W1968748902","https://openalex.org/W1969345006","https://openalex.org/W1969665961","https://openalex.org/W1979800232","https://openalex.org/W1986604538","https://openalex.org/W1986937402","https://openalex.org/W1987096080","https://openalex.org/W1989305101","https://openalex.org/W2006113448","https://openalex.org/W2010053675","https://openalex.org/W2016079519","https://openalex.org/W2017363328","https://openalex.org/W2018009295","https://openalex.org/W2035678974","https://openalex.org/W2036146722","https://openalex.org/W2046245027","https://openalex.org/W2054036401","https://openalex.org/W2057946199","https://openalex.org/W2061596342","https://openalex.org/W2085843470","https://openalex.org/W2089287416","https://openalex.org/W2096758188","https://openalex.org/W2098441538","https://openalex.org/W2100143432","https://openalex.org/W2107972234","https://openalex.org/W2114149902","https://openalex.org/W2122304368","https://openalex.org/W2126122220","https://openalex.org/W2134554242","https://openalex.org/W2141366450","https://openalex.org/W2156299764","https://openalex.org/W2165308016","https://openalex.org/W2398491052","https://openalex.org/W2401758330","https://openalex.org/W2408100331","https://openalex.org/W2408778242","https://openalex.org/W2414143183","https://openalex.org/W2416966756","https://openalex.org/W2437120592"],"related_works":["https://openalex.org/W2008071450","https://openalex.org/W2091553814","https://openalex.org/W1973028752","https://openalex.org/W2414143183","https://openalex.org/W2590006427","https://openalex.org/W2994416550","https://openalex.org/W2082026751","https://openalex.org/W2978510277","https://openalex.org/W2089287416","https://openalex.org/W7056057206"],"abstract_inverted_index":{"It":[0],"is":[1,16,37,66,76,105,270],"well":[2,296],"established":[3],"that":[4,27,86,268],"microsatellite":[5,29],"instability":[6],"(MSI),":[7],"the":[8,89,111,124,149,190,282,301],"hallmark":[9],"of":[10,43,52,81,115,123,126,132,151,160,173,189,243,248,289,300,303],"defective":[11],"DNA":[12],"mismatch":[13],"repair":[14],"(MMR),":[15],"associated":[17,271],"with":[18,25,56,169,175,194,200,227,272],"prolonged":[19],"survival":[20,53,91,104,129,197,225,259],"in":[21,33,54,69,93,130,148,260,275,291],"colorectal":[22,35],"cancer":[23,133,306],"compared":[24,199,226],"tumours":[26,36,70,177,208,213,290],"are":[28,47],"stable":[30],"(MSS).":[31],"MSI":[32,65,127,162,176,188,207,257,269,304],"sporadic":[34],"primarily":[38],"due":[39],"to":[40,196],"epigenetic":[41],"silencing":[42],"MLH1.":[44],"However,":[45],"there":[46,75],"no":[48,252],"prospective":[49],"population-based":[50],"studies":[51],"patients":[55,134,168,174,204],"germline":[57,98,179],"MMR":[58,99,292],"gene":[59,100,293],"mutations":[60,101],"who":[61],"develop":[62],"cancer.":[63],"Although":[64],"almost":[67],"universal":[68],"from":[71],"HNPCC":[72,94],"family":[73],"members,":[74],"a":[77,156],"potential":[78],"confounding":[79],"effect":[80],"ascertainment":[82],"and":[83,186,198,222,240,258,286],"other":[84],"biases":[85],"could":[87],"explain":[88],"apparent":[90],"benefit":[92],"families.":[95],"Resolving":[96],"whether":[97],"impact":[102],"on":[103,128,164,305],"important":[106],"because":[107],"it":[108],"potentially":[109],"undermines":[110],"rationale":[112,283],"for":[113,284],"surveillance":[114,285],"mutation":[116],"carriers.":[117],"Here,":[118],"we":[119,264],"report":[120],"an":[121],"investigation":[122],"influence":[125,159,302],"cohorts":[131],"(aged":[135],"<":[136,210,215],"30":[137],"years":[138],"at":[139,238],"diagnosis,":[140],"n":[141,145],"=":[142,146],"118;":[143],"non-age-selected,":[144],"181)":[147],"context":[150],"clinicopathologic":[152],"variables.":[153],"There":[154,250],"was":[155,251],"substantial":[157],"age-related":[158],"tumour":[161,170,187,256],"status":[163],"survival.":[165,249],"In":[166],"young":[167,261],"MSI,":[171],"65%":[172],"had":[178,205],"MSH2":[180],"or":[181],"MLH1":[182],"mutations.":[183],"Clinicopathologic":[184],"variables":[185],"cohort":[191],"were":[192],"studied":[193],"respect":[195],"control":[201],"groups.":[202],"Young":[203],"excess":[206],"(p":[209,214,219],"0.000001),":[211],"mucinous":[212],"0.01),":[216],"advanced":[217],"disease":[218],"approximately":[220],"0.001)":[221],"poorer":[223],"5-year":[224],"older":[228],"cases.":[229],"Cox":[230],"proportional":[231],"hazard":[232],"analysis":[233],"identified":[234],"Dukes'":[235],"stage,":[236],"age":[237],"diagnosis":[239],"calendar":[241],"year":[242],"treatment":[244],"as":[245,295,297],"independent":[246],"predictors":[247],"detectable":[253],"association":[254],"between":[255],"patients,":[262],"although":[263],"confirmed":[265],"previous":[266],"observations":[267],"better":[273],"prognosis":[274],"later":[276],"onset":[277],"cohorts.":[278],"These":[279],"findings":[280],"underscore":[281],"early":[287],"identification":[288],"carriers":[294],"refining":[298],"understanding":[299],"progression.":[307]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
