{"id":"https://openalex.org/W1997201471","doi":"https://doi.org/10.1002/jat.951","title":"Assessment of the skin sensitization potency of eugenol and its dimers using a non\u2010radioisotopic modi\ufb01cation of the local lymph node assay","display_name":"Assessment of the skin sensitization potency of eugenol and its dimers using a non\u2010radioisotopic modi\ufb01cation of the local lymph node assay","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1997201471","doi":"https://doi.org/10.1002/jat.951","mag":"1997201471","pmid":"https://pubmed.ncbi.nlm.nih.gov/14745850"},"language":"en","primary_location":{"id":"doi:10.1002/jat.951","doi":"https://doi.org/10.1002/jat.951","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.951","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079927458","display_name":"Masahiro Takeyoshi","orcid":"https://orcid.org/0000-0001-8941-2076","observed_orcids":["https://orcid.org/0000-0001-8941-2076"]},"institutions":[{"id":"https://openalex.org/I4210155996","display_name":"Chemicals Evaluation and Research Institute","ror":"https://ror.org/05b6qj426","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210155996"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Takeyoshi","raw_affiliation_strings":["Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan. takeyoshi-masahiro@ceri.jp","Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan. takeyoshi-masahiro@ceri.jp","institution_ids":["https://openalex.org/I4210155996"]},{"raw_affiliation_string":"Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan","institution_ids":["https://openalex.org/I4210155996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112205677","display_name":"Shuji Noda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155996","display_name":"Chemicals Evaluation and Research Institute","ror":"https://ror.org/05b6qj426","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210155996"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Noda","raw_affiliation_strings":["Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan","institution_ids":["https://openalex.org/I4210155996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065497241","display_name":"Shunsuke Yamazaki","orcid":"https://orcid.org/0009-0001-5507-8724","observed_orcids":["https://orcid.org/0009-0001-5507-8724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Yamazaki","raw_affiliation_strings":["Cosmetic Laboratory, Kanebo Ltd., 5-3-28, Kotobuki-cho, Odawara, Kanagawa 2500002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmetic Laboratory, Kanebo Ltd., 5-3-28, Kotobuki-cho, Odawara, Kanagawa 2500002, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090482705","display_name":"Hiroshi Kakishima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Kakishima","raw_affiliation_strings":["Cosmetic Laboratory, Kanebo Ltd., 5-3-28, Kotobuki-cho, Odawara, Kanagawa 2500002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmetic Laboratory, Kanebo Ltd., 5-3-28, Kotobuki-cho, Odawara, Kanagawa 2500002, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063418044","display_name":"Kanji Yamasaki","orcid":"https://orcid.org/0000-0001-5175-0053","observed_orcids":["https://orcid.org/0000-0001-5175-0053"]},"institutions":[{"id":"https://openalex.org/I4210155996","display_name":"Chemicals Evaluation and Research Institute","ror":"https://ror.org/05b6qj426","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210155996"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanji Yamasaki","raw_affiliation_strings":["Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3-822, Ishii-machi, Hita-shi, Oita 8770061, Japan","institution_ids":["https://openalex.org/I4210155996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085384594","display_name":"Ian Kimber","orcid":"https://orcid.org/0000-0002-3538-8581","observed_orcids":["https://orcid.org/0000-0002-3538-8581"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian Kimber","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta Central Toxicology Laboratory, Alderley Park, Maccles\ufb01eld, Cheshire, SK10 4TJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Maccles\ufb01eld, Cheshire, SK10 4TJ, UK","institution_ids":["https://openalex.org/I4210087094"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079927458"],"corresponding_institution_ids":["https://openalex.org/I4210155996"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":1.8706,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83536222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"77","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":0.953000009059906},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.8700000047683716},{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.9269999861717224},{"id":"https://openalex.org/keywords/allergic-contact-dermatitis","display_name":"allergic contact dermatitis","score":0.843999981880188},{"id":"https://openalex.org/keywords/local-lymph-node-assay","display_name":"local lymph node assay","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bromodeoxyuridine","display_name":"bromodeoxyuridine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/guinea-pig-maximization-test","display_name":"guinea pig maximization test","score":0.9649999737739563},{"id":"https://openalex.org/keywords/stimulation-index","display_name":"stimulation index","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2780614586","wikidata":"https://www.wikidata.org/wiki/Q6664446","display_name":"Local lymph node assay","level":4,"score":0.9628109931945801},{"id":"https://openalex.org/C3018346242","wikidata":"https://www.wikidata.org/wiki/Q4826986","display_name":"Skin sensitization","level":3,"score":0.8893287181854248},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.7879066467285156},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.668922483921051},{"id":"https://openalex.org/C2780470866","wikidata":"https://www.wikidata.org/wiki/Q423357","display_name":"Eugenol","level":2,"score":0.5465221405029297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4997718334197998},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4916754364967346},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.40700697898864746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3227127194404602},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24843677878379822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1435786485671997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13678091764450073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11003619432449341},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08418989181518555}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023441","descriptor_name":"Local Lymph Node Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jat.951","doi":"https://doi.org/10.1002/jat.951","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.951","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:14745850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14745850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/7ffab65a-0e58-4b4a-ae79-f4810c4dab29","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/7ffab65a-0e58-4b4a-ae79-f4810c4dab29","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Takeyoshi, M, Noda, S, Yamazaki, S, Kakishima, H, Yamasaki, K & Kimber, I 2004, 'Assessment of the skin sensitization potency of eugenol and its dimers using a non-radioisotopic modification of the local lymph node assay', Journal of Applied Toxicology, vol. 24, no. 1, pp. 77-81. https://doi.org/10.1002/jat.951","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W198336809","https://openalex.org/W1753071495","https://openalex.org/W1963577642","https://openalex.org/W2028598695","https://openalex.org/W2041795762","https://openalex.org/W2067932098","https://openalex.org/W2086279866","https://openalex.org/W2110108389","https://openalex.org/W2116387860","https://openalex.org/W2952822525","https://openalex.org/W4255520262"],"related_works":["https://openalex.org/W2137415100","https://openalex.org/W2116387860","https://openalex.org/W2012252934","https://openalex.org/W2148595739","https://openalex.org/W2132842859","https://openalex.org/W2054865262","https://openalex.org/W2143069022","https://openalex.org/W2043219954","https://openalex.org/W2147728377","https://openalex.org/W2121112784"],"abstract_inverted_index":{"Allergic":[0],"contact":[1,90],"dermatitis":[2],"is":[3,9,260],"a":[4,10,50,87,122,128,158,261],"serious":[5],"health":[6],"problem.":[7],"There":[8],"need":[11,262],"to":[12,22,65,147,156,195,255,263],"identify":[13],"and":[14,92,97,132,212],"characterize":[15],"skin":[16,82,124,130,137,172],"sensitization":[17],"hazards,":[18],"particularly":[19],"with":[20,232],"respect":[21],"relative":[23,171,223],"potency,":[24],"so":[25],"that":[26,220,245],"accurate":[27],"risk":[28],"assessments":[29,221],"can":[30],"be":[31],"developed.":[32,44],"For":[33],"these":[34,176,217],"purposes":[35],"the":[36,81,104,113,140,181,243,246,256,265],"murine":[37],"local":[38],"lymph":[39,67],"node":[40,68],"assay":[41],"(LLNA)":[42],"was":[43,119,154,178],"Here,":[45],"we":[46,78],"have":[47,79],"investigated":[48],"further":[49],"modi":[51],"fi":[52],"cation":[53],"of":[54,62,73,85,115,162,175,186,192,199,222,267],"this":[55,76],"assay,":[56],"non-radioisotopic":[57,141,182,227,247],"LLNA,":[58],"which":[59],"in":[60,103,180],"place":[61],"tritiated":[63],"thymidine":[64],"measure":[66],"cell":[69],"proliferation":[70],"employs":[71],"incorporation":[72],"5-bromo-2'-deoxyuridine.":[74],"Using":[75],"method":[77],"examined":[80],"sensitizing":[83,173],"activity":[84],"eugenol,":[86,208],"known":[88],"human":[89],"allergen,":[91],"its":[93],"dimers":[94],"2,2'-dihydroxyl-3,3'-dimethoxy-5,5'-diallyl-biphenyl":[95],"(DHEA)":[96],"4,5'-diallyl-2'-hydroxy-2,3'-dimethoxy":[98],"phenyl":[99],"ether":[100],"(DHEB).":[101],"Activity":[102],"guinea":[105],"pig":[106],"maximization":[107],"test":[108,168],"(GPMT)":[109],"also":[110],"measured.":[111],"On":[112],"basis":[114],"GPMT":[116,236,257],"assays,":[117],"eugenol":[118],"classified":[120],"as":[121,127,134,152,251],"mild":[123],"sensitizer,":[125],"DHEA":[126,211],"weak":[129],"sensitizer":[131],"DHEB":[133],"an":[135,187,197,252],"extreme":[136],"sensitizer.":[138],"In":[139],"LLNA":[142,183,228,248],"all":[143],"chemicals":[144,177],"were":[145,205],"found":[146],"give":[148],"positive":[149],"responses":[150,229],"insofar":[151],"each":[153],"able":[155],"provoke":[157,196],"stimulation":[159],"index":[160],"(SI)":[161],">or=3":[163],"at":[164],"one":[165],"or":[166],"more":[167],"concentrations.":[169],"The":[170,201],"potency":[174,224],"evaluated":[179],"by":[184],"derivation":[185],"ec(3)":[188,202],"value":[189],"(the":[190],"concentration":[191],"chemical":[193],"required":[194],"SI":[198],"3).":[200],"values":[203],"calculated":[204],"25.1%":[206],"for":[207,210,214,242],">30%":[209],"2.3%":[213],"DHEB.":[215],"Collectively":[216],"data":[218],"suggest":[219],"deriving":[225],"from":[226],"correlate":[230],"well":[231],"evaluations":[233],"based":[234],"on":[235],"results.":[237],"These":[238],"investigations":[239],"provide":[240],"support":[241],"proposal":[244],"may":[249],"serve":[250],"effective":[253],"alternative":[254],"where":[258],"there":[259],"avoid":[264],"use":[266],"radioisotopes.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
