{"id":"https://openalex.org/W1997188068","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a32","title":"Abstract A32: In vivo imaging of ERK activity of mouse breast cancer cells reveals heterogeneity in response to anti-cancer drugs and tumor forming capacity","display_name":"Abstract A32: In vivo imaging of ERK activity of mouse breast cancer cells reveals heterogeneity in response to anti-cancer drugs and tumor forming capacity","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1997188068","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a32","mag":"1997188068"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.fbcr13-a32","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a32","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.fbcr13-a32","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078848738","display_name":"Yuka Kumagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Kumagai","raw_affiliation_strings":["Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026764864","display_name":"Michiyuki Matsuda","orcid":"https://orcid.org/0000-0002-5876-9969","observed_orcids":["https://orcid.org/0000-0002-5876-9969"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiyuki Matsuda","raw_affiliation_strings":["Kyoto University, Kyoto, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"19_Supplement","first_page":"A32","last_page":"A32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.14749999344348907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk-activity","display_name":"ERK activity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mmtv-neu-mice","display_name":"MMTV-Neu mice","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fret-based-biosensors","display_name":"FRET biosensor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.7870000004768372},{"id":"https://openalex.org/keywords/two-photon-microscopy","display_name":"two-photon microscopy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.652999997138977},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pd0325901","display_name":"PD0325901","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-sphere-formation","display_name":"tumor sphere formation","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7834081053733826},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.6731679439544678},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6667892336845398},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6527283787727356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.621955156326294},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5569952726364136},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5056114196777344},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47093501687049866},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46933284401893616},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.41964399814605713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4002147316932678},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35031893849372864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3481709957122803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3359184265136719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2469661831855774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21868225932121277},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2035590410232544},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.08278688788414001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059300750494003296},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.fbcr13-a32","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a32","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.fbcr13-a32","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085198453","https://openalex.org/W2155975494","https://openalex.org/W2936756322","https://openalex.org/W1967947358","https://openalex.org/W2030403179","https://openalex.org/W2914466450","https://openalex.org/W1977067332","https://openalex.org/W2564260252","https://openalex.org/W2153599512","https://openalex.org/W7221120518"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"Ras-Raf-MEK-ERK":[2],"pathway":[3],"is":[4],"critical":[5],"for":[6,11,46],"normal":[7],"physiological":[8],"development":[9],"and":[10,84,119,133,168,171,184,248],"carcinogenesis.":[12],"However,":[13],"the":[14,65,77,80,91,95,102,111,128,134,191,211,256],"activity":[15,55,97,151,167,200,214,235],"of":[16,67,146,233,236,255],"this":[17],"signaling":[18],"cascade":[19],"has":[20],"never":[21],"been":[22],"examined":[23],"in":[24,56,69,86,110,126,152,180,187,222,243,263],"living":[25,57],"cancer":[26,219,239],"tissues":[27,58],"due":[28],"to":[29,51,159,202,218,245],"technical":[30],"difficulty.":[31],"We":[32,161],"have":[33],"recently":[34],"developed":[35,193],"transgenic":[36],"mice":[37,75,78],"expressing":[38,79],"a":[39,143],"F\u00f6rster":[40],"resonance":[41],"energy":[42],"transfer":[43],"(FRET)":[44],"biosensor":[45,83],"ERK,":[47],"which":[48],"allows":[49],"us":[50],"monitor":[52],"cellular":[53],"ERK":[54,68,81,96,125,150,166,199,213,234],"under":[59,88],"two-photon":[60],"(2P)":[61],"microscopes.":[62],"To":[63],"study":[64],"role":[66],"mammary":[70,93,130,136],"tumors,":[71,94],"we":[72,140],"crossed":[73],"MMTV-Neu":[74],"with":[76,148],"FRET":[82],"observed":[85],"vivo":[87,231],"2P.":[89],"In":[90,230],"primary":[92,129,153,203],"exhibited":[98,176,197],"significant":[99],"divergence":[100],"among":[101],"tumor":[103,113,131,137,185,249],"cells.":[104,114,138],"Such":[105],"heterogeneity":[106,242],"was":[107],"significantly":[108],"diminished":[109],"secondary":[112,135],"A":[115],"MEK":[116],"inhibitor":[117,122],"PD0325901":[118],"an":[120],"EGFR/HER2":[121],"Lapatinib":[123],"suppressed":[124],"both":[127],"cells":[132,147,163,196,240],"Interestingly,":[139],"found":[141],"that":[142,155,210],"small":[144],"number":[145],"low":[149],"tumors":[154,192],"did":[156],"not":[157],"respond":[158],"Lapatinib.":[160],"sorted":[162],"depending":[164],"on":[165,261],"obtained":[169],"ERKlow":[170,174,195],"ERKhigh":[172],"population.The":[173],"population":[175],"higher":[177],"tumorsphere":[178],"formation":[179,186],"nonadherent":[181],"culture":[182],"condition":[183],"syngeneic":[188],"mice.":[189],"Notably,":[190],"from":[194],"heterogeneous":[198,212],"similar":[201],"tumors.":[204,223],"Taken":[205],"together,":[206],"our":[207],"results":[208],"suggest":[209],"might":[215],"be":[216],"related":[217],"stem":[220],"cell":[221],"Citation":[224],"Format:":[225],"Yuka":[226],"Kumagai,":[227],"Michiyuki":[228],"Matsuda.":[229],"imaging":[232],"mouse":[237],"breast":[238],"reveals":[241],"response":[244],"anti-cancer":[246],"drugs":[247],"forming":[250],"capacity.":[251],"[abstract].":[252],"In:":[253],"Proceedings":[254],"Third":[257],"AACR":[258],"International":[259],"Conference":[260],"Frontiers":[262],"Basic":[264],"Cancer":[265,276],"Research;":[266],"Sep":[267],"18-22,":[268],"2013;":[269],"National":[270],"Harbor,":[271],"MD.":[272],"Philadelphia":[273],"(PA):":[274],"AACR;":[275],"Res":[277],"2013;73(19":[278],"Suppl):Abstract":[279],"nr":[280],"A32.":[281]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
