{"id":"https://openalex.org/W1997146483","doi":"https://doi.org/10.1074/jbc.m114.557454","title":"Regulation of Endothelial Cell Barrier Function by Antibody-driven Affinity Modulation of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)","display_name":"Regulation of Endothelial Cell Barrier Function by Antibody-driven Affinity Modulation of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)","publication_year":2014,"publication_date":"2014-06-17","ids":{"openalex":"https://openalex.org/W1997146483","doi":"https://doi.org/10.1074/jbc.m114.557454","mag":"1997146483","pmid":"https://pubmed.ncbi.nlm.nih.gov/24936065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4110291"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m114.557454","doi":"https://doi.org/10.1074/jbc.m114.557454","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.557454","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m114.557454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048815633","display_name":"Heng Mei","orcid":"https://orcid.org/0000-0001-7941-2443","observed_orcids":["https://orcid.org/0000-0001-7941-2443"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Mei","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005677196","display_name":"Jay M. Campbell","orcid":"https://orcid.org/0000-0002-9916-2055","observed_orcids":["https://orcid.org/0000-0002-9916-2055"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay M. Campbell","raw_affiliation_strings":["Materials Science Center, University of Wisconsin, Madison, Wisconsin 54701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science Center, University of Wisconsin, Madison, Wisconsin 54701","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076149795","display_name":"Cathy M. Paddock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy M. Paddock","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067172101","display_name":"Panida Lertkiatmongkol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panida Lertkiatmongkol","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111847857","display_name":"Michael W. Mosesson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Mosesson","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111547829","display_name":"Ralph M. Albrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Albrecht","raw_affiliation_strings":["Department of Animal Sciences, Pediatrics, and Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 54701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Pediatrics, and Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 54701","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043749891","display_name":"Peter J. Newman","orcid":"https://orcid.org/0000-0001-8853-7707","observed_orcids":["https://orcid.org/0000-0001-8853-7707"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Newman","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043749891"],"corresponding_institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4210117001"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.0771,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93675214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"289","issue":"30","first_page":"20836","last_page":"20844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":1.0},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.8479999899864197},{"id":"https://openalex.org/keywords/homophilic-adhesion","display_name":"homophilic adhesion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/leukocyte-transendothelial-migration","display_name":"leukocyte transendothelial migration","score":0.8669999837875366},{"id":"https://openalex.org/keywords/endothelial-junctions","display_name":"endothelial junctions","score":0.828000009059906},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7961419224739075},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.7060667276382446},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.6936833262443542},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.571499228477478},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.49665290117263794},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4766819477081299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4680366814136505},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4488610327243805},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.44112229347229004},{"id":"https://openalex.org/C183521119","wikidata":"https://www.wikidata.org/wiki/Q5058397","display_name":"Cell\u2013cell interaction","level":3,"score":0.4199664294719696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3822382986545563},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34099531173706055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2056940197944641},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1899760663509369},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0852600634098053}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008567","descriptor_name":"Membranes, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m114.557454","doi":"https://doi.org/10.1074/jbc.m114.557454","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.557454","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3488840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4110291","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4110291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4110291","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:24936065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24936065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m114.557454","doi":"https://doi.org/10.1074/jbc.m114.557454","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.557454","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1731509664","display_name":"Molecular & Cellular Mechanisms in Transfusion Medicine","funder_award_id":"P01HL044612","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1898485612","display_name":null,"funder_award_id":"HL-40926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6237039664","display_name":"Molecular Biology and Function of PECAM-1","funder_award_id":"R01HL040926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W274441265","https://openalex.org/W1512900768","https://openalex.org/W1598629441","https://openalex.org/W1607157162","https://openalex.org/W1739820884","https://openalex.org/W1857298428","https://openalex.org/W1962538984","https://openalex.org/W1964570763","https://openalex.org/W1965320114","https://openalex.org/W1976658012","https://openalex.org/W1977707298","https://openalex.org/W1993266029","https://openalex.org/W1995958961","https://openalex.org/W2002018258","https://openalex.org/W2005574282","https://openalex.org/W2019055633","https://openalex.org/W2028047806","https://openalex.org/W2033358607","https://openalex.org/W2034626872","https://openalex.org/W2037150903","https://openalex.org/W2049760106","https://openalex.org/W2049866297","https://openalex.org/W2053770942","https://openalex.org/W2055755227","https://openalex.org/W2056027939","https://openalex.org/W2061344749","https://openalex.org/W2067811751","https://openalex.org/W2074466423","https://openalex.org/W2076544464","https://openalex.org/W2083052252","https://openalex.org/W2084830265","https://openalex.org/W2089352646","https://openalex.org/W2090106721","https://openalex.org/W2091002608","https://openalex.org/W2099961094","https://openalex.org/W2108833806","https://openalex.org/W2109342412","https://openalex.org/W2113111549","https://openalex.org/W2117538259","https://openalex.org/W2121781131","https://openalex.org/W2127396428","https://openalex.org/W2139340137","https://openalex.org/W2149332837","https://openalex.org/W2152364499","https://openalex.org/W2152532559","https://openalex.org/W2153853402","https://openalex.org/W2155895966","https://openalex.org/W2159495568","https://openalex.org/W2160811005","https://openalex.org/W2160899469","https://openalex.org/W2164487251","https://openalex.org/W2166833739","https://openalex.org/W2169303813","https://openalex.org/W2169778726","https://openalex.org/W2171139467","https://openalex.org/W2189322842","https://openalex.org/W2293815148","https://openalex.org/W2404821003","https://openalex.org/W2417318333","https://openalex.org/W4229609280","https://openalex.org/W6641085495"],"related_works":["https://openalex.org/W2979660149","https://openalex.org/W2083052252","https://openalex.org/W2317982666","https://openalex.org/W2008447781","https://openalex.org/W2061235037","https://openalex.org/W2159495568","https://openalex.org/W2177456672","https://openalex.org/W2417318333","https://openalex.org/W2004472590","https://openalex.org/W3125951432"],"abstract_inverted_index":{"PECAM-1":[0,48,81,155],"is":[1,11],"a":[2,39,52,83,170],"130-kDa":[3],"member":[4],"of":[5,16,25,79,137,154,172],"the":[6,14,22,76,135,151],"immunoglobulin":[7],"(Ig)":[8],"superfamily":[9],"that":[10,34,116,122,150],"expressed":[12],"on":[13],"surface":[15],"platelets":[17,91],"and":[18,20,67,92,166],"leukocytes,":[19],"at":[21],"intracellular":[23],"junctions":[24],"confluent":[26],"endothelial":[27,56,70,141,163],"cell":[28,71,142,164],"monolayers.":[29],"Previous":[30],"studies":[31],"have":[32],"shown":[33],"PECAM-1/PECAM-1":[35],"homophilic":[36],"interactions":[37,115],"play":[38],"key":[40],"role":[41],"in":[42,46,55,58,68,82,140,169],"leukocyte":[43],"transendothelial":[44],"migration,":[45],"allowing":[47],"to":[49,61,64,105,108,133,145],"serve":[50],"as":[51],"mechanosensory":[53],"complex":[54],"cells,":[57,110],"its":[59],"ability":[60,104],"confer":[62],"cytoprotection":[63],"proapoptotic":[65],"stimuli,":[66],"maintaining":[69],"junctional":[72],"integrity.":[73],"To":[74],"examine":[75],"adhesive":[77,114,152],"properties":[78,153],"full-length":[80],"native":[84],"lipid":[85],"environment,":[86],"we":[87],"purified":[88],"it":[89,94],"from":[90],"assembled":[93],"into":[95],"phospholipid":[96],"nanodiscs.":[97],"PECAM-1-containing":[98],"nanodiscs":[99],"retained":[100],"not":[101],"only":[102],"their":[103],"bind":[106,123],"homophilically":[107],"PECAM-1-expressing":[109],"but":[111],"exhibited":[112],"regulatable":[113,157],"could":[117],"be":[118],"modulated":[119],"by":[120],"ligands":[121],"membrane-":[124],"proximal":[125],"Ig":[126],"Domain":[127],"6.":[128],"This":[129],"property":[130],"was":[131],"exploited":[132],"enhance":[134],"rate":[136],"barrier":[138,167],"restoration":[139],"monolayers":[143],"subjected":[144],"inflammatory":[146],"challenge.":[147],"The":[148],"finding":[149],"are":[156],"suggests":[158],"novel":[159],"approaches":[160],"for":[161],"controlling":[162],"migration":[165],"function":[168],"variety":[171],"vascular":[173],"permeability":[174],"disorders.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
