{"id":"https://openalex.org/W1997140139","doi":"https://doi.org/10.1089/omi.2009.0011","title":"Risk Assessment and Communication Tools for Genotype Associations with Multifactorial Phenotypes: The Concept of \u201cEdge Effect\u201d and Cultivating an Ethical Bridge between Omics Innovations and Society","display_name":"Risk Assessment and Communication Tools for Genotype Associations with Multifactorial Phenotypes: The Concept of \u201cEdge Effect\u201d and Cultivating an Ethical Bridge between Omics Innovations and Society","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W1997140139","doi":"https://doi.org/10.1089/omi.2009.0011","mag":"1997140139","pmid":"https://pubmed.ncbi.nlm.nih.gov/19290811","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2727354"},"language":"en","primary_location":{"id":"doi:10.1089/omi.2009.0011","doi":"https://doi.org/10.1089/omi.2009.0011","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2009.0011","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2727354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012423795","display_name":"Vural \u00d6zdemir","orcid":"https://orcid.org/0000-0002-5117-759X","observed_orcids":["https://orcid.org/0000-0002-5117-759X"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vural Ozdemir","raw_affiliation_strings":["Department of Social and Preventive Medicine, Bioethics Programs, Faculty of Medicine, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social and Preventive Medicine, Bioethics Programs, Faculty of Medicine, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074411363","display_name":"Guilherme Suarez\u2010Kurtz","orcid":"https://orcid.org/0000-0002-1115-8319","observed_orcids":["https://orcid.org/0000-0002-1115-8319"]},"institutions":[{"id":"https://openalex.org/I4210142683","display_name":"Instituto Nacional de C\u00e2ncer - INCA","ror":"https://ror.org/055n68305","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210142683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Suarez-Kurtz","raw_affiliation_strings":["Division of Pharmacology, Instituto Nacional de C\u00e2ncer, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Instituto Nacional de C\u00e2ncer, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4210142683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002193386","display_name":"R. Stenne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rapha\u00eblle Stenne","raw_affiliation_strings":["Department of Biomedical Sciences, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada","Department of Biomedical Sciences, University of Montreal, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089827696","display_name":"Andrew Alexander Somogyi","orcid":"https://orcid.org/0000-0003-4779-0380","observed_orcids":["https://orcid.org/0000-0003-4779-0380"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew A. Somogyi","raw_affiliation_strings":["Discipline of Pharmacology, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Pharmacology, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044283342","display_name":"Toshiyuki Someya","orcid":"https://orcid.org/0000-0003-2505-4470","observed_orcids":["https://orcid.org/0000-0003-2505-4470","https://orcid.org/0000-0002-3259-4224"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Someya","raw_affiliation_strings":["Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081114796","display_name":"S. O\u01e7uz Kayaalp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I376670","display_name":"Turkish Academy of Sciences","ror":"https://ror.org/00aqt9352","country_code":"TR","type":"government","lineage":["https://openalex.org/I376670"]},{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S. O\u011fuz Kayaalp","raw_affiliation_strings":["Turkish Academy of Sciences (TUBA) and Faculty of Medicine, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turkish Academy of Sciences (TUBA) and Faculty of Medicine, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I376670","https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087861388","display_name":"Eugene Kolker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Kolker","raw_affiliation_strings":["Bioinformatics and High-Throughput Data Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington","Biomedical and Health Informatics Division, Medical Education and Biomedical Informatics Department, University of Washington, Seattle, Washington","Predictive Analytics, Seattle Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and High-Throughput Data Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Biomedical and Health Informatics Division, Medical Education and Biomedical Informatics Department, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Predictive Analytics, Seattle Children's Hospital","institution_ids":["https://openalex.org/I1295499534"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.346,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95071963,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"43","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edge-effects","display_name":"edge effects","score":0.859000027179718},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.6790000200271606},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6650000214576721},{"id":"https://openalex.org/keywords/risk-communication","display_name":"risk communication","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vkorc1","display_name":"VKORC1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.6349999904632568},{"id":"https://openalex.org/keywords/regulatory-guidance","display_name":"regulatory guidelines","score":0.5410000085830688},{"id":"https://openalex.org/keywords/public-trust","display_name":"public trust","score":0.5379999876022339},{"id":"https://openalex.org/keywords/technology-assessment","display_name":"technology assessment","score":0.6959999799728394},{"id":"https://openalex.org/keywords/nutrigenomics","display_name":"nutrigenomics","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ecogenomics","display_name":"ecogenomics","score":0.972000002861023},{"id":"https://openalex.org/keywords/brazilian-population","display_name":"Brazilian population","score":0.777999997138977},{"id":"https://openalex.org/keywords/stakeholder-conflict","display_name":"stakeholder conflict","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.7561958432197571},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.5938273668289185},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5359811186790466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4943573474884033},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.46871820092201233},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.45491504669189453},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.43812304735183716},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3454596996307373},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3428802490234375},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30913206934928894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27971380949020386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23873662948608398},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2060510814189911},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18583634495735168},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14602407813072205},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14079302549362183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003142","descriptor_name":"Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003933","descriptor_name":"Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011153","descriptor_name":"Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1089/omi.2009.0011","doi":"https://doi.org/10.1089/omi.2009.0011","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2009.0011","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2727354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2727354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS","raw_type":"Text"},{"id":"pmid:19290811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19290811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Omics : a journal of integrative biology","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/50706","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/50706","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1089/omi.2009.0011","raw_type":"Journal article"},{"id":"pmh:oai:openaccess.hacettepe.edu.tr:11655/16047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11655/16047","pdf_url":null,"source":{"id":"https://openalex.org/S4306402578","display_name":"Hacettepe University Institutional Repository (hacettepe.edu.tr)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66514158","host_organization_name":"Hacettepe University","host_organization_lineage":["https://openalex.org/I66514158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/514223","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/514223","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"323610","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2727354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2727354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8066916288","display_name":"Coordinating Center for Beta Cell Biology Consortium","funder_award_id":"U01DK072473","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W521352","https://openalex.org/W98654930","https://openalex.org/W107015616","https://openalex.org/W157642396","https://openalex.org/W196869739","https://openalex.org/W219619262","https://openalex.org/W319904515","https://openalex.org/W430451116","https://openalex.org/W592433216","https://openalex.org/W617987273","https://openalex.org/W626485227","https://openalex.org/W1411330736","https://openalex.org/W1518891040","https://openalex.org/W1552987906","https://openalex.org/W1585922775","https://openalex.org/W1596599977","https://openalex.org/W1605057828","https://openalex.org/W1623913395","https://openalex.org/W1627330950","https://openalex.org/W1629123370","https://openalex.org/W1806928656","https://openalex.org/W1947945212","https://openalex.org/W1964318336","https://openalex.org/W1965763721","https://openalex.org/W1973404359","https://openalex.org/W1976339191","https://openalex.org/W1977284458","https://openalex.org/W1979196241","https://openalex.org/W1989391549","https://openalex.org/W1996022962","https://openalex.org/W1997965740","https://openalex.org/W2002767187","https://openalex.org/W2003392791","https://openalex.org/W2003410018","https://openalex.org/W2003532890","https://openalex.org/W2003967393","https://openalex.org/W2004004137","https://openalex.org/W2006575800","https://openalex.org/W2006914590","https://openalex.org/W2013856177","https://openalex.org/W2015488487","https://openalex.org/W2016501463","https://openalex.org/W2018020999","https://openalex.org/W2021034741","https://openalex.org/W2021889472","https://openalex.org/W2024875479","https://openalex.org/W2028227064","https://openalex.org/W2030321893","https://openalex.org/W2030881336","https://openalex.org/W2031642214","https://openalex.org/W2031990482","https://openalex.org/W2034285001","https://openalex.org/W2035864980","https://openalex.org/W2037113639","https://openalex.org/W2037171637","https://openalex.org/W2037519865","https://openalex.org/W2037520119","https://openalex.org/W2038776626","https://openalex.org/W2040550914","https://openalex.org/W2044164200","https://openalex.org/W2048416680","https://openalex.org/W2049217578","https://openalex.org/W2049477821","https://openalex.org/W2051348934","https://openalex.org/W2055267088","https://openalex.org/W2056551158","https://openalex.org/W2057726553","https://openalex.org/W2058111723","https://openalex.org/W2060598494","https://openalex.org/W2062222093","https://openalex.org/W2063975494","https://openalex.org/W2065586027","https://openalex.org/W2066198266","https://openalex.org/W2066659961","https://openalex.org/W2067180774","https://openalex.org/W2068446440","https://openalex.org/W2071332031","https://openalex.org/W2077301821","https://openalex.org/W2077354992","https://openalex.org/W2078006500","https://openalex.org/W2078749292","https://openalex.org/W2079524824","https://openalex.org/W2082540912","https://openalex.org/W2083861429","https://openalex.org/W2084686194","https://openalex.org/W2085845187","https://openalex.org/W2085846085","https://openalex.org/W2088992809","https://openalex.org/W2091838939","https://openalex.org/W2092325965","https://openalex.org/W2092484446","https://openalex.org/W2093714545","https://openalex.org/W2094714679","https://openalex.org/W2096954709","https://openalex.org/W2101827544","https://openalex.org/W2103542844","https://openalex.org/W2104058573","https://openalex.org/W2105746988","https://openalex.org/W2110294090","https://openalex.org/W2110925860","https://openalex.org/W2112238768","https://openalex.org/W2116000709","https://openalex.org/W2116153150","https://openalex.org/W2116460666","https://openalex.org/W2120172040","https://openalex.org/W2121221571","https://openalex.org/W2123678584","https://openalex.org/W2124667978","https://openalex.org/W2127005440","https://openalex.org/W2129682733","https://openalex.org/W2132163703","https://openalex.org/W2132477232","https://openalex.org/W2132490382","https://openalex.org/W2136646511","https://openalex.org/W2137221887","https://openalex.org/W2139149616","https://openalex.org/W2139240683","https://openalex.org/W2139452536","https://openalex.org/W2140911647","https://openalex.org/W2145118720","https://openalex.org/W2145974353","https://openalex.org/W2151137583","https://openalex.org/W2151341073","https://openalex.org/W2151936813","https://openalex.org/W2152787007","https://openalex.org/W2152852883","https://openalex.org/W2153387822","https://openalex.org/W2154798437","https://openalex.org/W2155253059","https://openalex.org/W2156714835","https://openalex.org/W2159874791","https://openalex.org/W2162679089","https://openalex.org/W2164474957","https://openalex.org/W2166743175","https://openalex.org/W2320765338","https://openalex.org/W2337249715","https://openalex.org/W2400119897","https://openalex.org/W2409318121","https://openalex.org/W2471360278","https://openalex.org/W2517098993","https://openalex.org/W2550965594","https://openalex.org/W2604799231","https://openalex.org/W2612373536","https://openalex.org/W2755078217","https://openalex.org/W2799137111","https://openalex.org/W2906790474","https://openalex.org/W2991434184","https://openalex.org/W3014385642","https://openalex.org/W4245213889","https://openalex.org/W4248016744","https://openalex.org/W4251007455","https://openalex.org/W4285719527","https://openalex.org/W4298439559"],"related_works":["https://openalex.org/W7061526795","https://openalex.org/W2091806847","https://openalex.org/W2102059289","https://openalex.org/W2497014423","https://openalex.org/W1979242230","https://openalex.org/W3193608663","https://openalex.org/W2031897491","https://openalex.org/W2417303638","https://openalex.org/W2056678827","https://openalex.org/W7099761762"],"abstract_inverted_index":{"Applications":[0],"of":[1,28,49,109,116,132,146,156,180,186,197,242,250,259,273,305,325,329,368,386],"omics":[2,30,53,182,228,306,320,330,347,369],"technologies":[3],"in":[4,33,52,93,98,114,119,153,205,216,244,255,262,271,279,327,346],"the":[5,94,99,107,130,144,151,171,187,201,231,317,339],"postgenomics":[6],"era":[7],"swiftly":[8],"expanded":[9],"from":[10,69,338,384],"rare":[11],"monogenic":[12],"disorders":[13],"to":[14,62,75,169,218,268,289,315,335,341,362,375,388],"multifactorial":[15,158],"common":[16],"complex":[17],"diseases,":[18],"pharmacogenomics,":[19],"and":[20,40,57,60,64,135,175,200,236,275,288,296,308,322,353,366,393,397],"personalized":[21],"medicine.":[22],"Already,":[23],"there":[24],"are":[25,46,214,253,294,298,356],"signposts":[26],"indicative":[27],"further":[29],"technology":[31,399],"investment":[32],"nutritional":[34],"sciences":[35],"(nutrigenomics),":[36],"environmental":[37],"health/ecology":[38],"(ecogenomics),":[39],"agriculture":[41],"(agrigenomics).":[42],"Genotype-phenotype":[43],"association":[44,70,83,122,139,223,292],"studies":[45,71,84,293],"a":[47,79,120,125,157,162,206,238,248,343,377],"centerpiece":[48],"translational":[50],"research":[51],"science.":[54],"Yet":[55],"scientific":[56,280],"ethical":[58],"standards":[59,297],"ways":[61],"assess":[63],"communicate":[65],"risk":[66,133,260],"information":[67,261],"obtained":[68],"have":[72,247],"been":[73],"neglected":[74],"date.":[76],"This":[77],"is":[78,161,191,332],"significant":[80],"gap":[81,318],"because":[82],"decisively":[85],"influence":[86],"which":[87],"genetic":[88,91,100,121,203],"loci":[89],"become":[90],"tests":[92],"clinic":[95],"or":[96],"products":[97],"test":[101],"marketplace.":[102],"A":[103],"growing":[104],"challenge":[105],"concerns":[106],"interpretation":[108],"large":[110],"overlap":[111],"typically":[112],"observed":[113],"distribution":[115],"quantitative":[117,159],"traits":[118],"study":[123],"with":[124],"polygenic/multifactorial":[126],"phenotype.":[127],"To":[128,302],"remedy":[129,334],"shortage":[131],"assessment":[134],"communication":[136,258],"tools":[137],"for":[138,222,282],"studies,":[140],"this":[141],"paper":[142],"presents":[143],"concept":[145,190],"edge":[147,188,211],"effect.":[148],"That":[149],"is,":[150],"shift":[152],"population":[154,167,172,208],"edges":[155],"phenotype":[160],"more":[163,357],"sensitive":[164],"measure":[165,361],"(than":[166],"averages)":[168],"gauge":[170],"level":[173],"impact":[174],"by":[176,286],"extension,":[177],"policy":[178],"significance":[179],"an":[181,194],"marker.":[183],"Empirical":[184],"application":[185],"effect":[189,212],"illustrated":[192],"using":[193],"original":[195],"analysis":[196],"warfarin":[198],"pharmacogenomics":[199],"VKORC1":[202],"variation":[204],"Brazilian":[207],"sample.":[209],"These":[210],"analyses":[213,396],"examined":[215],"relation":[217],"regulatory":[219],"guidance":[220],"development":[221],"studies.":[224],"We":[225],"explain":[226],"that":[227,252,355],"science":[229,331],"transcends":[230],"conventional":[232],"laboratory":[233,321],"bench":[234],"space":[235],"includes":[237],"highly":[239],"heterogeneous":[240],"cast":[241],"stakeholders":[243],"society":[245],"who":[246],"plurality":[249],"interests":[251],"often":[254],"conflict.":[256],"Hence,":[257],"diagnostic":[263],"medicine":[264],"also":[265],"demands":[266],"attention":[267],"processes":[269],"involved":[270],"production":[272],"knowledge":[274],"human":[276],"values":[277],"embedded":[278],"practice,":[281],"example,":[283],"why,":[284],"how,":[285],"whom,":[287],"what":[290],"ends":[291],"conducted,":[295],"developed":[299],"(or":[300],"not).":[301],"ensure":[303,342],"sustainability":[304,367],"innovations":[307],"forecast":[309],"their":[310],"trajectory,":[311],"we":[312],"need":[313],"interventions":[314],"bridge":[316],"between":[319],"society.":[323],"Appreciation":[324],"scholarship":[326],"history":[328],"one":[333],"responsibly":[336],"learn":[337],"past":[340],"sustainable":[344],"future":[345],"fields,":[348],"both":[349],"emerging":[350],"(nutrigenomics,":[351],"ecogenomics),":[352],"those":[354],"established":[358],"(pharmacogenomics).":[359],"Another":[360],"build":[363],"public":[364],"trust":[365],"fields":[370],"could":[371],"be":[372],"legislative":[373],"initiatives":[374],"create":[376],"multidisciplinary":[378],"oversight":[379],"body,":[380],"at":[381],"arm's":[382],"length":[383],"conflict":[385],"interests,":[387],"carry":[389],"out":[390],"independent,":[391],"impartial,":[392],"transparent":[394],"innovation":[395],"prospective":[398],"assessment.":[400]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
