{"id":"https://openalex.org/W1997122713","doi":"https://doi.org/10.1073/pnas.79.16.4988","title":"Tumor-promoter-resistant cells lack trisialoganglioside response.","display_name":"Tumor-promoter-resistant cells lack trisialoganglioside response.","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W1997122713","doi":"https://doi.org/10.1073/pnas.79.16.4988","mag":"1997122713","pmid":"https://pubmed.ncbi.nlm.nih.gov/6956909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/346811"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.79.16.4988","doi":"https://doi.org/10.1073/pnas.79.16.4988","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.16.4988","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L Srinivas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Srinivas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027575395","display_name":"Thomas D. Gindhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T D Gindhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048962207","display_name":"Nancy H. Colburn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N H Colburn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5303,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81159754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"79","issue":"16","first_page":"4988","last_page":"4991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.3041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/jb6-epidermal-cells","display_name":"JB6 epidermal cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/sialoglycoconjugates","display_name":"sialoglycoconjugates","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gangliosides","display_name":"gangliosides","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.4480000138282776},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.7963954210281372},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.6566615104675293},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.560806155204773},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5269250273704529},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5238235592842102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.486640065908432},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.4773036241531372},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47471940517425537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44933316111564636},{"id":"https://openalex.org/C2909761558","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"Tetradecanoylphorbol Acetate","level":4,"score":0.4416464567184448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36845964193344116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3680001497268677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33585864305496216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2542172074317932},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24486592411994934},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.2090478539466858},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12622559070587158},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.09048441052436829}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010704","descriptor_name":"Phorbols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.79.16.4988","doi":"https://doi.org/10.1073/pnas.79.16.4988","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.16.4988","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:346811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6956909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6956909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:346811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1512094340","https://openalex.org/W1540191125","https://openalex.org/W1771691146","https://openalex.org/W1900423039","https://openalex.org/W1941237551","https://openalex.org/W1960078512","https://openalex.org/W1973907819","https://openalex.org/W1974170868","https://openalex.org/W1978064025","https://openalex.org/W1982739312","https://openalex.org/W1988142577","https://openalex.org/W1994028952","https://openalex.org/W1996497544","https://openalex.org/W2016086566","https://openalex.org/W2029770423","https://openalex.org/W2030533124","https://openalex.org/W2032585326","https://openalex.org/W2039450453","https://openalex.org/W2046983903","https://openalex.org/W2052624177","https://openalex.org/W2061390773","https://openalex.org/W2064762154","https://openalex.org/W2068502595","https://openalex.org/W2085433407","https://openalex.org/W2119672886","https://openalex.org/W2126779118","https://openalex.org/W2130474643","https://openalex.org/W2474028837"],"related_works":["https://openalex.org/W2115894706","https://openalex.org/W4300951025","https://openalex.org/W2025044881","https://openalex.org/W2402252820","https://openalex.org/W2113008499","https://openalex.org/W2416352163","https://openalex.org/W1887000505","https://openalex.org/W7098639859","https://openalex.org/W2126779118","https://openalex.org/W2169788527"],"abstract_inverted_index":{"JB6":[0,40],"mouse":[1],"epidermal":[2],"cells":[3,41,56,69],"shift":[4],"irreversibly":[5],"to":[6,24,42,83,90,116,121,140],"tumor":[7,21],"cell":[8,147],"phenotype":[9,161],"(anchorage":[10],"independence":[11],"and":[12,19,57,92,103],"tumorigenicity)":[13],"on":[14],"treatment":[15],"with":[16],"phorbol":[17,25,135],"esters":[18],"other":[20,97],"promoters.":[22],"Exposure":[23],"12-myristate":[26],"13-acetate":[27],"(PMA)":[28],"decreased":[29],"the":[30,108,117,159],"de":[31],"novo":[32],"synthesis":[33],"of":[34,44,46,63,67,73,86,107,111,119,133,153,158,166],"trisialoganglioside":[35],"(GT)":[36],"in":[37,54,59],"these":[38],"\"promotable\"":[39],"5-10%":[43],"that":[45,150],"untreated":[47],"cells.":[48],"The":[49,105],"GT":[50,64,91,112,127,137],"decrease":[51],"occurred":[52],"consistently":[53],"promotion-sensitive":[55],"not":[58,94,129],"promotion-resistant":[60],"variants.":[61],"Insertion":[62],"into":[65],"membranes":[66],"PMA-treated":[68],"inhibited":[70],"PMA":[71,120],"promotion":[72,85],"transformation":[74,87],"as":[75,124],"measured":[76],"by":[77,96,145],"agar":[78,142],"colony":[79,143],"induction.":[80],"This":[81],"ability":[82],"inhibit":[84,130],"is":[88,93,138,155],"specific":[89,131],"shared":[95],"sialoglycoconjugates,":[98],"including":[99],"gangliosides":[100],"GM1,":[101],"GD1a,":[102],"asialo-GM1.":[104],"mechanism":[106],"blocking":[109],"activity":[110],"must":[113],"be":[114],"distal":[115],"binding":[118,132],"its":[122,151],"receptors,":[123],"exogenously":[125],"added":[126],"does":[128],"tritiated":[134],"diester.":[136],"unable":[139],"block":[141],"formation":[144],"transformed":[146,160],"lines,":[148],"showing":[149],"level":[152],"action":[154],"at":[156,164],"induction":[157],"rather":[162],"than":[163],"expression":[165],"it.":[167]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}