{"id":"https://openalex.org/W1997122005","doi":"https://doi.org/10.1590/s1984-82502012000300003","title":"Myostatin: genetic variants, therapy and gene doping","display_name":"Myostatin: genetic variants, therapy and gene doping","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W1997122005","doi":"https://doi.org/10.1590/s1984-82502012000300003","mag":"1997122005"},"language":"en","primary_location":{"id":"doi:10.1590/s1984-82502012000300003","doi":"https://doi.org/10.1590/s1984-82502012000300003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1984-82502012000300003","pdf_url":"https://www.scielo.br/j/bjps/a/4qYDpQYcjTmHcbhFfckLs7d/?lang=en&format=pdf","source":{"id":"https://openalex.org/S120884445","display_name":"Brazilian Journal of Pharmaceutical Sciences","issn_l":"1984-8250","issn":["1984-8250","2175-9790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/bjps/a/4qYDpQYcjTmHcbhFfckLs7d/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022473958","display_name":"Andr\u00e9 Katayama Yamada","orcid":"https://orcid.org/0000-0002-2894-5407","observed_orcids":["https://orcid.org/0000-0002-2894-5407"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Katayama Yamada","raw_affiliation_strings":["Federal University of S\u00e3o Carlos"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Carlos","institution_ids":["https://openalex.org/I177909021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031295964","display_name":"Roz\u00e2ngela Verlengia","orcid":"https://orcid.org/0000-0001-8626-0476","observed_orcids":["https://orcid.org/0000-0001-8626-0476"]},"institutions":[{"id":"https://openalex.org/I4210095520","display_name":"Methodist University of Piracicaba","ror":"https://ror.org/00shzgx32","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210095520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rozangela Verlengia","raw_affiliation_strings":["University Methodist of Piracicaba","University Methodist of Piracicaba; College of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Methodist of Piracicaba","institution_ids":["https://openalex.org/I4210095520"]},{"raw_affiliation_string":"University Methodist of Piracicaba; College of Health Sciences","institution_ids":["https://openalex.org/I4210095520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006954341","display_name":"Carlos Roberto Bueno J\u00fanior","orcid":"https://orcid.org/0000-0002-2228-0758","observed_orcids":["https://orcid.org/0000-0002-2228-0758"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Carlos Roberto Bueno Junior","raw_affiliation_strings":["University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006954341"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":0.3072,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.48723343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"48","issue":"3","first_page":"369","last_page":"377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12700","display_name":"Doping in Sports","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":1.0},{"id":"https://openalex.org/keywords/mstn-gene","display_name":"MSTN gene","score":0.8140000104904175},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-doping","display_name":"gene doping","score":0.7369999885559082},{"id":"https://openalex.org/keywords/muscle-hypertrophy","display_name":"muscle hypertrophy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/pharmacological-inhibition","display_name":"pharmacological inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/athletic-performance","display_name":"athletic performance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/doping-detection","display_name":"doping detection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.6399999856948853},{"id":"https://openalex.org/keywords/adipose-tissue-thermogenesis","display_name":"adipose tissue thermogenesis","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.8997243642807007},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.6646406650543213},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5342409014701843},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.5333818197250366},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5087183117866516},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49536073207855225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45611000061035156},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.42969927191734314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4147145748138428},{"id":"https://openalex.org/C117365660","wikidata":"https://www.wikidata.org/wiki/Q962589","display_name":"Myokine","level":3,"score":0.4115895926952362},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3966929316520691},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3953555226325989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3461373746395111},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30135563015937805},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.28087425231933594}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1590/s1984-82502012000300003","doi":"https://doi.org/10.1590/s1984-82502012000300003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1984-82502012000300003","pdf_url":"https://www.scielo.br/j/bjps/a/4qYDpQYcjTmHcbhFfckLs7d/?lang=en&format=pdf","source":{"id":"https://openalex.org/S120884445","display_name":"Brazilian Journal of Pharmaceutical Sciences","issn_l":"1984-8250","issn":["1984-8250","2175-9790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S1984-82502012000300003","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1984-82502012000300003","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences v.48 n.3 2012","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/40699","doi":null,"is_oa":false,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/40699","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.905.3113","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.905.3113","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.scielo.br/pdf/bjps/v48n3/a03v48n3.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:2366701","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2366701","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences v.48 n.3 2012","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6624a3e2df884b6bb5f1e4d7a66b12c8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6624a3e2df884b6bb5f1e4d7a66b12c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences, Vol 48, Iss 3, Pp 369-377 (2012)","raw_type":"article"},{"id":"pmh:oai:revistas.usp.br:article/47850","doi":null,"is_oa":true,"landing_page_url":"https://www.revistas.usp.br/bjps/article/view/47850","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1590/s1984-82502012000300003","doi":"https://doi.org/10.1590/s1984-82502012000300003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1984-82502012000300003","pdf_url":"https://www.scielo.br/j/bjps/a/4qYDpQYcjTmHcbhFfckLs7d/?lang=en&format=pdf","source":{"id":"https://openalex.org/S120884445","display_name":"Brazilian Journal of Pharmaceutical Sciences","issn_l":"1984-8250","issn":["1984-8250","2175-9790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997122005.pdf","grobid_xml":"https://content.openalex.org/works/W1997122005.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1483774964","https://openalex.org/W1801917292","https://openalex.org/W1969741000","https://openalex.org/W1970202047","https://openalex.org/W1975294859","https://openalex.org/W1980579696","https://openalex.org/W1981960353","https://openalex.org/W1983415262","https://openalex.org/W1986842655","https://openalex.org/W2000865765","https://openalex.org/W2001759531","https://openalex.org/W2006167464","https://openalex.org/W2013018684","https://openalex.org/W2014893491","https://openalex.org/W2018988532","https://openalex.org/W2024688164","https://openalex.org/W2027579570","https://openalex.org/W2029816532","https://openalex.org/W2034074403","https://openalex.org/W2034893773","https://openalex.org/W2047284298","https://openalex.org/W2048134135","https://openalex.org/W2053079324","https://openalex.org/W2055746744","https://openalex.org/W2076582667","https://openalex.org/W2081287636","https://openalex.org/W2083700023","https://openalex.org/W2085548226","https://openalex.org/W2085943981","https://openalex.org/W2087034573","https://openalex.org/W2093424805","https://openalex.org/W2094179659","https://openalex.org/W2099849009","https://openalex.org/W2102638170","https://openalex.org/W2108645449","https://openalex.org/W2114796514","https://openalex.org/W2120136245","https://openalex.org/W2124932935","https://openalex.org/W2127061742","https://openalex.org/W2134539584","https://openalex.org/W2137242970","https://openalex.org/W2143888267","https://openalex.org/W2144331482","https://openalex.org/W2146469014","https://openalex.org/W2149030353","https://openalex.org/W2150324560","https://openalex.org/W2160578478","https://openalex.org/W2163727456","https://openalex.org/W2165868509","https://openalex.org/W2165995731","https://openalex.org/W2166485013","https://openalex.org/W2166877291","https://openalex.org/W2169357998","https://openalex.org/W2169876318","https://openalex.org/W2170262804"],"related_works":["https://openalex.org/W1893925664","https://openalex.org/W2771666674","https://openalex.org/W7165385505","https://openalex.org/W1992600611","https://openalex.org/W2005008151","https://openalex.org/W2554957350","https://openalex.org/W7038586677","https://openalex.org/W2356454766","https://openalex.org/W831771010","https://openalex.org/W2351376256"],"abstract_inverted_index":{"Since":[0],"its":[1,162],"discovery,":[2],"myostatin":[3],"(MSTN)":[4],"has":[5],"been":[6],"at":[7],"the":[8,81,88,102,115,133,141],"forefront":[9],"of":[10,19,80,84,91,104,114,161],"muscle":[11,30,37,61,151],"therapy":[12,73],"research":[13],"because":[14,79],"intrinsic":[15],"mutations":[16],"or":[17,25],"inhibition":[18,40],"this":[20],"protein,":[21],"by":[22],"either":[23],"pharmacological":[24],"genetic":[26,122],"means,":[27],"result":[28],"in":[29,71,99,130,159,165],"hypertrophy":[31],"and":[32,59,101,127,154],"hyperplasia.":[33],"In":[34],"addition":[35],"to":[36,46,119,132],"growth,":[38],"MSTN":[39,134,143],"potentially":[41],"disturbs":[42],"connective":[43],"tissue,":[44],"leads":[45],"strength":[47],"modulation,":[48],"facilitates":[49],"myoblast":[50],"transplantation,":[51],"promotes":[52],"tissue":[53,57],"regeneration,":[54],"induces":[55],"adipose":[56],"thermogenesis":[58],"increases":[60],"oxidative":[62],"phenotype.":[63],"It":[64],"is":[65,118],"also":[66],"known":[67],"that":[68],"current":[69],"advances":[70],"gene":[72,106,166],"have":[74],"an":[75],"impact":[76,95],"on":[77,96],"sports":[78],"illicit":[82],"use":[83,164],"such":[85],"methods.":[86],"However,":[87],"adverse":[89],"effects":[90],"these":[92],"methods,":[93],"their":[94],"athletic":[97,128],"performance":[98,129],"humans":[100],"means":[103],"detecting":[105],"doping":[107,126],"are":[108],"as":[109,145],"yet":[110],"unknown.":[111],"The":[112],"aim":[113],"present":[116],"review":[117],"discuss":[120],"biosynthesis,":[121],"variants,":[123],"pharmacological/genetic":[124],"manipulation,":[125],"relation":[131],"pathway.":[135],"As":[136],"will":[137],"be":[138],"concluded":[139],"from":[140],"manuscript,":[142],"emerges":[144],"a":[146],"promising":[147],"molecule":[148],"for":[149,155],"combating":[150],"wasting":[152],"diseases":[153],"triggering":[156],"wide-ranging":[157],"discussion":[158],"view":[160],"possible":[163],"doping.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
