{"id":"https://openalex.org/W1997096094","doi":"https://doi.org/10.4161/cc.5.17.3187","title":"Spatial Segregation of Ras Signaling\u2014New Evidence from Fission Yeast","display_name":"Spatial Segregation of Ras Signaling\u2014New Evidence from Fission Yeast","publication_year":2006,"publication_date":"2006-08-15","ids":{"openalex":"https://openalex.org/W1997096094","doi":"https://doi.org/10.4161/cc.5.17.3187","mag":"1997096094","pmid":"https://pubmed.ncbi.nlm.nih.gov/16931912","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826191"},"language":"en","primary_location":{"id":"doi:10.4161/cc.5.17.3187","doi":"https://doi.org/10.4161/cc.5.17.3187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.17.3187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.17.3187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.17.3187?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075269512","display_name":"Eric C. Chang","orcid":"https://orcid.org/0000-0002-1375-5088","observed_orcids":["https://orcid.org/0000-0002-1375-5088"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Chang","raw_affiliation_strings":["Baylor College of Medicine, Department of Molecular and Cell Biology, The Breast Center, Houston, Texas 77030, USA. echang@breastcenter.tmc.edu","Baylor College of Medicine, Department of Molecular and Cell Biology, The Breast Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Department of Molecular and Cell Biology, The Breast Center, Houston, Texas 77030, USA. echang@breastcenter.tmc.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine, Department of Molecular and Cell Biology, The Breast Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067102350","display_name":"Mark R. Philips","orcid":"https://orcid.org/0000-0002-1179-8156","observed_orcids":["https://orcid.org/0000-0002-1179-8156"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Philips","raw_affiliation_strings":["New York University School of Medicine ; Department of Medicine, Cell Biology and Pharmacology ; New York , New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University School of Medicine ; Department of Medicine, Cell Biology and Pharmacology ; New York , New York","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1363,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.1020707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"17","first_page":"1936","last_page":"1939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/compartmentalized-signaling","display_name":"compartmentalized signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/spatial-segregation","display_name":"spatial segregation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mating-pheromone-signaling","display_name":"mating pheromone signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.8410000205039978},{"id":"https://openalex.org/keywords/plasma-membrane-localization","display_name":"plasma membrane localization","score":0.7360000014305115},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8732020854949951},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7489848732948303},{"id":"https://openalex.org/C2779429346","wikidata":"https://www.wikidata.org/wiki/Q2236682","display_name":"Schizosaccharomyces pombe","level":4,"score":0.7006174325942993},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.69251549243927},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.678551197052002},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6261186003684998},{"id":"https://openalex.org/C127812441","wikidata":"https://www.wikidata.org/wiki/Q4774319","display_name":"Anti-apoptotic Ras signalling cascade","level":4,"score":0.5442323088645935},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.5127957463264465},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.4833645224571228},{"id":"https://openalex.org/C206052861","wikidata":"https://www.wikidata.org/wiki/Q899827","display_name":"Endomembrane system","level":4,"score":0.42210865020751953},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.41476181149482727},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.3429165780544281},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.28543519973754883},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.27240657806396484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.263561487197876},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.18878856301307678},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18670904636383057},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.13290631771087646},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.13199830055236816}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.5.17.3187","doi":"https://doi.org/10.4161/cc.5.17.3187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.17.3187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.17.3187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:16931912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16931912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2826191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Cycle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cc.5.17.3187","doi":"https://doi.org/10.4161/cc.5.17.3187","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.5.17.3187","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.5.17.3187?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1867246295","display_name":null,"funder_award_id":"GM55279","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2200290623","display_name":"Compartment Specific Signaling of Ras","funder_award_id":"R01GM055279","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2808193213","display_name":"Regulation of K-Ras by a Farnesyl-electrostatic Switch","funder_award_id":"R01CA116034","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3896083991","display_name":null,"funder_award_id":"CA90464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4317585257","display_name":null,"funder_award_id":"CA107187","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5544117794","display_name":"Structure/Function Analysis of Icmt","funder_award_id":"R01CA118495","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6923034717","display_name":null,"funder_award_id":"CA116034","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6961031165","display_name":"Selective control of multiple Ras signaling activities","funder_award_id":"R01CA107187","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6965995057","display_name":null,"funder_award_id":"CA118495","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8579666923","display_name":"REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY","funder_award_id":"R01CA090464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997096094.pdf","grobid_xml":"https://content.openalex.org/works/W1997096094.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1552158310","https://openalex.org/W1852817901","https://openalex.org/W1986383101","https://openalex.org/W1986827801","https://openalex.org/W1988588097","https://openalex.org/W1993407233","https://openalex.org/W2008014792","https://openalex.org/W2013446521","https://openalex.org/W2014656185","https://openalex.org/W2046961979","https://openalex.org/W2052371969","https://openalex.org/W2053579461","https://openalex.org/W2069800089","https://openalex.org/W2071818252","https://openalex.org/W2073201826","https://openalex.org/W2079389107","https://openalex.org/W2082634075","https://openalex.org/W2094901755","https://openalex.org/W2117669008","https://openalex.org/W2123392030","https://openalex.org/W2135242575","https://openalex.org/W2146407537","https://openalex.org/W2151862262","https://openalex.org/W2152401699","https://openalex.org/W2154383549","https://openalex.org/W2156571424","https://openalex.org/W2159594827","https://openalex.org/W2162658068","https://openalex.org/W2163065574","https://openalex.org/W2165803049","https://openalex.org/W2172047190","https://openalex.org/W2415707200"],"related_works":["https://openalex.org/W2172047190","https://openalex.org/W1586919599","https://openalex.org/W3172151641","https://openalex.org/W2039358229","https://openalex.org/W2146889169","https://openalex.org/W7154691167","https://openalex.org/W7095120001","https://openalex.org/W852098304","https://openalex.org/W1598663084","https://openalex.org/W2332737941"],"abstract_inverted_index":{"The":[0],"Ras":[1,26,38,50,65,92,106,118,132,149],"GTPases":[2],"act":[3],"as":[4],"binary":[5],"switches":[6],"for":[7,14,171],"signal":[8],"transduction":[9],"pathways":[10,86],"that":[11,62,87,120,130],"are":[12,40,88],"important":[13,46],"growth":[15],"regulation":[16],"and":[17,31,162],"tumorigenesis.":[18],"Despite":[19],"the":[20,32,35,109,135,152],"biochemical":[21],"simplicity":[22],"of":[23,34,80,174],"this":[24,81],"switch,":[25],"proteins":[27,39],"control":[28,68],"multiple":[29],"pathways,":[30],"functions":[33,70],"four":[36],"mammalian":[37],"not":[41],"overlapping.":[42],"This":[43,127,165],"raises":[44],"an":[45],"question--how":[47],"does":[48],"a":[49,54,63,98,140,155],"protein":[51,66,119,163],"selectively":[52,89,138],"regulate":[53],"particular":[55,99],"activity?":[56],"One":[57],"recently":[58],"emerging":[59],"model":[60,82],"suggests":[61],"single":[64],"can":[67],"different":[69],"by":[71,91],"acting":[72],"in":[73,108],"distinct":[74],"cellular":[75],"compartments.":[76],"A":[77,101],"critical":[78],"test":[79],"is":[83,95],"to":[84,97,134,144,151,158],"identify":[85],"controlled":[90],"when":[93],"it":[94],"localized":[96,133,150],"compartment.":[100],"recent":[102],"study":[103,128,166],"has":[104,167],"examined":[105],"signaling":[107,173],"fission":[110],"yeast":[111],"Schizosaccharomyces":[112],"pombe,":[113],"which":[114],"expresses":[115],"only":[116],"one":[117],"controls":[121],"two":[122],"separate":[123],"evolutionarily":[124],"conserved":[125],"pathways.":[126],"demonstrates":[129],"whereas":[131],"plasma":[136],"membrane":[137],"regulates":[139],"MAP":[141],"kinase":[142],"pathway":[143,157],"mediate":[145,159],"mating":[146],"pheromone":[147],"signaling,":[148],"endomembrane":[153],"activates":[154],"Cdc42":[156],"cell":[160],"polarity":[161],"trafficking.":[164],"provided":[168],"unambiguous":[169],"evidence":[170],"compartmentalized":[172],"Ras.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}