{"id":"https://openalex.org/W1997068010","doi":"https://doi.org/10.1158/1538-7445.am2011-5382","title":"Abstract 5382: Anti-tumor efficacy of a recombinant human arginase in combination with chemotherapeutic agents in human hepatocellular carcinoma","display_name":"Abstract 5382: Anti-tumor efficacy of a recombinant human arginase in combination with chemotherapeutic agents in human hepatocellular carcinoma","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1997068010","doi":"https://doi.org/10.1158/1538-7445.am2011-5382","mag":"1997068010"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-5382","doi":"https://doi.org/10.1158/1538-7445.am2011-5382","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5382","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079566680","display_name":"Ariel Ka-Man Chow","orcid":"https://orcid.org/0000-0002-5729-5415","observed_orcids":["https://orcid.org/0000-0002-5729-5415"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ariel Chow","raw_affiliation_strings":["1The University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111624702","display_name":"Roberta W. C. Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Roberta Pang","raw_affiliation_strings":["1The University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111641201","display_name":"Andrew C. Y. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Andrew Chu","raw_affiliation_strings":["1The University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089434925","display_name":"Lui Ng","orcid":"https://orcid.org/0000-0002-9010-2654","observed_orcids":["https://orcid.org/0000-0002-9010-2654"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lui Ng","raw_affiliation_strings":["1The University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108482517","display_name":"Ronnie T. P. Poon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ronnie Poon","raw_affiliation_strings":["1The University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"5382","last_page":"5382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.25999999046325684,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase","display_name":"argininosuccinate synthetase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8320000171661377},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/eif4e","display_name":"eIF4E","score":0.9459999799728394},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.7718195915222168},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7092400193214417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6544210314750671},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6217138171195984},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5906246900558472},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.5652363896369934},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5366430282592773},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.47602468729019165},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.47003453969955444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44703638553619385},{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.4180448055267334},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36524707078933716},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31361907720565796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27593499422073364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25591546297073364},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.24717006087303162},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.10778859257698059},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.10705339908599854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09042271971702576},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1538-7445.am2011-5382","doi":"https://doi.org/10.1158/1538-7445.am2011-5382","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5382","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:hub.hku.hk:10722/137925","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/137925","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141106530","https://openalex.org/W2725201658","https://openalex.org/W1980238151","https://openalex.org/W6998769921","https://openalex.org/W2590416822","https://openalex.org/W3153390253","https://openalex.org/W2276110376","https://openalex.org/W4406379681","https://openalex.org/W2066858504","https://openalex.org/W2104338176"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Systemic":[2],"chemotherapy":[3,281,299,324],"of":[4,35,37,81,87,96,101,116,154,179,205,226,241,278,290,292,308,320,328,338,343],"hepatocellular":[5],"carcinoma":[6],"(HCC)":[7],"relies":[8],"on":[9,93,125],"few":[10],"drugs":[11],"and":[12,54,71,83,91,105,119,131,141,146,152,159,220,238,244,269,280,323],"the":[13,33,79,84,94,149,318,339,344],"response":[14],"rates":[15],"are":[16],"low":[17],"especially":[18],"in":[19,50,97,106,123,136,148,168,186,234,262,314,325],"patients":[20],"with":[21,89,188,211,228,256,282,296,310],"advanced":[22],"HCC.":[23,329],"HCC":[24,102],"is":[25],"considered":[26],"as":[27],"auxotrophic":[28],"for":[29,347],"arginine":[30,70],"due":[31],"to":[32,47,68,216],"lack":[34],"expression":[36,147,153,271],"argininosuccinate":[38],"synthetase":[39],"(ASS).":[40],"Several":[41],"recombinant":[42,61],"human":[43,62,137],"arginases":[44],"were":[45,134,161,174,195],"found":[46,215,233],"be":[48],"effective":[49],"inhibiting":[51,235],"liver,":[52],"pancreatic":[53],"leukemic":[55],"cell":[56,99,103,126,128,218,236],"proliferation.":[57],"Recently,":[58],"a":[59],"new":[60],"arginase,":[63],"BCT-100,":[64,117],"has":[65],"been":[66],"synthesized":[67],"deprive":[69],"inhibit":[72,217],"arginine-dependent":[73],"tumor":[74,108,201,293],"growth.":[75],"In":[76],"this":[77],"study,":[78],"efficacy":[80,115],"BCT-100":[82,88,185,212,227,257,279,297,309,322],"combined":[85],"used":[86],"cisplatin":[90,118,189,229,284],"fluorouracil":[92,191,231,286],"inhibition":[95,291],"vitro":[98],"proliferation":[100,219,237],"lines":[104],"vivo":[107,169],"growth":[109,294],"was":[110,192,214,232,253,272],"studied.":[111],"Method:":[112],"The":[113],"anti-tumor":[114],"fluorouracil,":[120],"alone":[121,213],"or":[122,190,199,230,285,298],"combination,":[124],"proliferation,":[127],"cycle":[129,248],"distribution":[130],"cellular":[132,222],"apoptosis":[133,240],"determined":[135],"hepatoma":[138],"HepG2,":[139,242],"Hep3B":[140,243],"PLC/PRF/5":[142,245],"cells.":[143,246],"Protein":[144],"phosphorylation":[145],"Wnt/\u03b2-catenin":[150],"pathways,":[151],"cyclin":[155,264],"D1,":[156,265],"eIF4E,":[157,267],"survivin":[158,268],"XIAP,":[160],"also":[162,254],"analyzed":[163],"by":[164,176],"western":[165],"blotting.":[166],"For":[167],"animal":[170],"studies,":[171],"subcutaneous":[172,177],"tumors":[173],"established":[175],"injections":[178],"1\u00d7106":[180],"cells":[181],"into":[182],"nude":[183],"mice.":[184],"combination":[187],"administrated.":[193],"Mice":[194],"sacrificed":[196],"week":[197],"16":[198],"when":[200],"sizes":[202],"exceeded":[203],"30%":[204],"their":[206],"body":[207],"weight.":[208],"Results:":[209],"Treatment":[210],"enhance":[221],"apoptosis.":[223],"Additive":[224],"effect":[225,289,307],"increasing":[239],"Cell":[247],"arrest":[249],"at":[250],"G1/S":[251],"phase":[252],"observed":[255],"treatment.":[258],"A":[259],"significant":[260],"reduction":[261],"\u03b2-catenin,":[263],"phosphorylated":[266],"XIAP":[270],"observed.":[273],"Furthermore,":[274],"repeated":[275],"sequential":[276],"use":[277],"either":[283],"demonstrated":[287],"synergistic":[288],"compared":[295],"alone.":[300],"Conclusion:":[301],"These":[302],"pre-clinical":[303],"data":[304],"suggested":[305,317],"additive/synergistic":[306],"other":[311],"chemotherapeutic":[312],"agents":[313],"HCC,":[315],"which":[316],"rationale":[319],"combining":[321],"clinical":[326],"treatment":[327],"Citation":[330],"Format:":[331],"{Authors}.":[332],"{Abstract":[333],"title}":[334],"[abstract].":[335],"In:":[336],"Proceedings":[337],"102nd":[340],"Annual":[341],"Meeting":[342],"American":[345],"Association":[346],"Cancer":[348,358],"Research;":[349],"2011":[350],"Apr":[351],"2-6;":[352],"Orlando,":[353],"FL.":[354],"Philadelphia":[355],"(PA):":[356],"AACR;":[357],"Res":[359],"2011;71(8":[360],"Suppl):Abstract":[361],"nr":[362],"5382.":[363],"doi:10.1158/1538-7445.AM2011-5382":[364]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}