{"id":"https://openalex.org/W1997016283","doi":"https://doi.org/10.1002/ana.410380122","title":"Apolipoprotein E genotype in diverse neurodegenerative disorders","display_name":"Apolipoprotein E genotype in diverse neurodegenerative disorders","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W1997016283","doi":"https://doi.org/10.1002/ana.410380122","mag":"1997016283","pmid":"https://pubmed.ncbi.nlm.nih.gov/7611717"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410380122","doi":"https://doi.org/10.1002/ana.410380122","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410380122","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie A. Schneider","raw_affiliation_strings":["Veterans Affairs Medical Center, Decatur, GA 30033, USA","Department of Pathology and Labortory Medicine, Atlanta, GA","Veterans Affairs Medical Center, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center, Decatur, GA 30033, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Labortory Medicine, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063529297","display_name":"Marla Gearing","orcid":"https://orcid.org/0000-0002-1959-7412","observed_orcids":["https://orcid.org/0000-0002-1959-7412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marla Gearing","raw_affiliation_strings":["Department of Pathology and Labortory Medicine, Atlanta, GA","Veterans Affairs Medical Center, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Labortory Medicine, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086422229","display_name":"Ronen S. Robbins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronen S. Robbins","raw_affiliation_strings":["Department of Pathology and Labortory Medicine, Atlanta, GA","Veterans Affairs Medical Center, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Labortory Medicine, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007069","display_name":"William De l'Aune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William De l'Aune","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA","Veterans Affairs Medical Center, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062983762","display_name":"Suzanne Samuels Mirra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Suzanne S. Mirra","raw_affiliation_strings":["Department of Pathology and Labortory Medicine, Atlanta, GA","Veterans Affairs Medical Center, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Labortory Medicine, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Atlanta, GA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062983762"],"corresponding_institution_ids":[],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":6.2228,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.96949602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"1","first_page":"131","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7620000243186951},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.859000027179718},{"id":"https://openalex.org/keywords/pick-s-disease","display_name":"Pick's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/corticobasal-degeneration","display_name":"corticobasal degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.8760340213775635},{"id":"https://openalex.org/C2776936178","wikidata":"https://www.wikidata.org/wiki/Q1755684","display_name":"Corticobasal degeneration","level":4,"score":0.8735965490341187},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7626802921295166},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6724961996078491},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5195631980895996},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5114973783493042},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.46677297353744507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4659256637096405},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.44363078474998474},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.414357453584671},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3567291498184204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21161067485809326},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1566060483455658},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07157450914382935}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410380122","doi":"https://doi.org/10.1002/ana.410380122","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410380122","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:7611717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7611717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1054070016","display_name":"EMORY ALZHEIMERS DISEASE CENTER","funder_award_id":"P30AG010130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1086794002","display_name":null,"funder_award_id":"AG-10130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1965776676","https://openalex.org/W1965927800","https://openalex.org/W1982120496","https://openalex.org/W1999631936","https://openalex.org/W2001688761","https://openalex.org/W2003081257","https://openalex.org/W2010390315","https://openalex.org/W2021181758","https://openalex.org/W2034968148","https://openalex.org/W2053425135","https://openalex.org/W2065446074","https://openalex.org/W2079605884","https://openalex.org/W2091924214","https://openalex.org/W2111774300","https://openalex.org/W2134633907","https://openalex.org/W2142572810","https://openalex.org/W2143277340","https://openalex.org/W2146729934","https://openalex.org/W2159232889","https://openalex.org/W2171381656","https://openalex.org/W2171405125"],"related_works":["https://openalex.org/W2091527371","https://openalex.org/W1985137206","https://openalex.org/W2004308017","https://openalex.org/W2106900897","https://openalex.org/W1989867392","https://openalex.org/W2003070333","https://openalex.org/W2053404336","https://openalex.org/W2043759922","https://openalex.org/W1983765045","https://openalex.org/W1978942825"],"abstract_inverted_index":{"While":[0,107],"the":[1,76,111,139,149],"apolipoprotein":[2],"E":[3],"(ApoE)":[4],"epsilon":[5,20,72,87,130],"4":[6,21,73,88,131],"allele":[7],"is":[8],"a":[9],"recognized":[10],"risk":[11],"factor":[12],"for":[13,141],"Alzheimer's":[14],"disease":[15],"(AD),":[16],"an":[17,49,126],"association":[18,128],"of":[19,36,52,78,104,129,144,151],"with":[22,132],"other":[23],"neurodegenerative":[24],"diseases":[25],"(NDs)":[26],"has":[27],"not":[28,91],"been":[29],"extensively":[30],"explored.":[31],"We":[32],"examined":[33],"51":[34],"cases":[35,43,79,146],"neuropathologically":[37],"confirmed":[38],"ND.":[39,157],"After":[40],"eliminating":[41],"18":[42],"exhibiting":[44],"pathology":[45,155],"sufficient":[46],"to":[47,118,147,153],"warrant":[48],"additional":[50],"diagnosis":[51],"AD,":[53,120],"three":[54],"disorders":[55],"characterized":[56],"by":[57],"tau-related":[58],"cytoskeletal":[59,154],"pathology,":[60],"i.e.,":[61],"Pick's":[62],"disease,":[63],"corticobasal":[64],"degeneration,":[65],"and":[66,156],"progressive":[67],"supra-nuclear":[68],"palsy,":[69],"showed":[70],"increased":[71,86],"frequencies.":[74],"Since":[75],"number":[77],"within":[80],"each":[81],"category":[82],"was":[83],"small,":[84],"these":[85,105,114,121],"frequencies":[89],"were":[90,100,116],"statistically":[92],"significant.":[93],"beta-Amyloid":[94],"(beta":[95],"A4)":[96],"immunoreactive":[97],"diffuse":[98],"plaques":[99],"observed":[101],"in":[102],"many":[103],"cases.":[106],"we":[108],"cannot":[109],"eliminate":[110],"possibility":[112],"that":[113],"patients":[115],"destined":[117],"develop":[119],"changes":[122],"may":[123],"merely":[124],"reflect":[125],"independent":[127],"amyloid":[133],"deposition.":[134],"These":[135],"preliminary":[136],"data":[137],"affirm":[138],"need":[140],"further":[142],"study":[143],"well-characterized":[145],"explore":[148],"relationship":[150],"ApoE":[152]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}