{"id":"https://openalex.org/W1997014543","doi":"https://doi.org/10.3390/molecules18066230","title":"Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles","display_name":"Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles","publication_year":2013,"publication_date":"2013-05-24","ids":{"openalex":"https://openalex.org/W1997014543","doi":"https://doi.org/10.3390/molecules18066230","mag":"1997014543","pmid":"https://pubmed.ncbi.nlm.nih.gov/23708234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4374646"},"language":"en","primary_location":{"id":"doi:10.3390/molecules18066230","doi":"https://doi.org/10.3390/molecules18066230","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules18066230","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules18066230","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045578425","display_name":"Xufen Yu","orcid":"https://orcid.org/0000-0001-7794-7890","observed_orcids":["https://orcid.org/0000-0001-7794-7890"]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xufen Yu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA","institution_ids":["https://openalex.org/I35722693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012471499","display_name":"Dianqing Sun","orcid":"https://orcid.org/0000-0001-7330-1742","observed_orcids":["https://orcid.org/0000-0001-7330-1742"]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dianqing Sun","raw_affiliation_strings":["Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA","institution_ids":["https://openalex.org/I35722693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012471499"],"corresponding_institution_ids":["https://openalex.org/I35722693"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.7227,"has_fulltext":false,"cited_by_count":233,"citation_normalized_percentile":{"value":0.86026616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"18","issue":"6","first_page":"6230","last_page":"6268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.07360000163316727,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrocycle-synthesis","display_name":"macrocycle synthesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/macrolactonization","display_name":"macrolactonization","score":0.9070000052452087},{"id":"https://openalex.org/keywords/macrolactamization","display_name":"macrolactamization","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transition-metal-catalyzed-cross-coupling","display_name":"transition-metal-catalyzed cross-coupling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ring-closing-metathesis","display_name":"ring-closing metathesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.9200000166893005},{"id":"https://openalex.org/keywords/macrocyclic-natural-products","display_name":"macrocyclic natural products","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6113980412483215},{"id":"https://openalex.org/C2778593322","wikidata":"https://www.wikidata.org/wiki/Q7334670","display_name":"Ring-closing metathesis","level":5,"score":0.4910597801208496},{"id":"https://openalex.org/C153914509","wikidata":"https://www.wikidata.org/wiki/Q191090","display_name":"Metathesis","level":4,"score":0.46708011627197266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41726475954055786},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35602521896362305},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33231908082962036},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15731260180473328},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1454923450946808},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047028","descriptor_name":"Macrocyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047028","descriptor_name":"Macrocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules18066230","doi":"https://doi.org/10.3390/molecules18066230","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules18066230","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3336907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4374646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4374646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4374646","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:23708234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23708234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e6a4702d8ae94f33823d8c0dd85dd143","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6a4702d8ae94f33823d8c0dd85dd143","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 18, Iss 6, Pp 6230-6268 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules18066230","doi":"https://doi.org/10.3390/molecules18066230","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules18066230","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1020286742","display_name":"Development of Piperidinols and Engelhardiones as Novel Antituberculosis Agents","funder_award_id":"R15AI092315","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4449399334","display_name":null,"funder_award_id":"8 P20 GML 03466-11","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7041977012","display_name":"INBRE II: Hawaii Statewide Research & Education Partnership (HSREP)","funder_award_id":"P20RR016467","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000914798","display_name":"HAWAII INBRE V PROGRAM","funder_award_id":"P20GM103466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":250,"referenced_works":["https://openalex.org/W169459663","https://openalex.org/W998124995","https://openalex.org/W1856870847","https://openalex.org/W1965076619","https://openalex.org/W1966043736","https://openalex.org/W1966229978","https://openalex.org/W1967009050","https://openalex.org/W1968085118","https://openalex.org/W1968305342","https://openalex.org/W1968652549","https://openalex.org/W1969421659","https://openalex.org/W1971320547","https://openalex.org/W1971337445","https://openalex.org/W1972619164","https://openalex.org/W1973600020","https://openalex.org/W1973667932","https://openalex.org/W1974984023","https://openalex.org/W1975040572","https://openalex.org/W1976875907","https://openalex.org/W1976894600","https://openalex.org/W1979703254","https://openalex.org/W1980561497","https://openalex.org/W1981686319","https://openalex.org/W1982662224","https://openalex.org/W1984234137","https://openalex.org/W1984862410","https://openalex.org/W1984947099","https://openalex.org/W1985108907","https://openalex.org/W1985635789","https://openalex.org/W1986352004","https://openalex.org/W1986892641","https://openalex.org/W1986974113","https://openalex.org/W1987000069","https://openalex.org/W1987292873","https://openalex.org/W1987548761","https://openalex.org/W1987874099","https://openalex.org/W1988226038","https://openalex.org/W1989042060","https://openalex.org/W1989761771","https://openalex.org/W1991744668","https://openalex.org/W1992068754","https://openalex.org/W1993464054","https://openalex.org/W1993625795","https://openalex.org/W1995184998","https://openalex.org/W1995803037","https://openalex.org/W1996040078","https://openalex.org/W1996041307","https://openalex.org/W1996051767","https://openalex.org/W1996452574","https://openalex.org/W1998233841","https://openalex.org/W1998307795","https://openalex.org/W1998462789","https://openalex.org/W1998780987","https://openalex.org/W2000909844","https://openalex.org/W2002159747","https://openalex.org/W2003165249","https://openalex.org/W2003236802","https://openalex.org/W2003568095","https://openalex.org/W2004100816","https://openalex.org/W2004381166","https://openalex.org/W2004503571","https://openalex.org/W2006810880","https://openalex.org/W2009546256","https://openalex.org/W2009974966","https://openalex.org/W2011010559","https://openalex.org/W2012163448","https://openalex.org/W2012655453","https://openalex.org/W2014430771","https://openalex.org/W2015235532","https://openalex.org/W2015550348","https://openalex.org/W2017546955","https://openalex.org/W2018075747","https://openalex.org/W2021947577","https://openalex.org/W2022114028","https://openalex.org/W2022187233","https://openalex.org/W2022412731","https://openalex.org/W2023018411","https://openalex.org/W2025316967","https://openalex.org/W2025514182","https://openalex.org/W2026059754","https://openalex.org/W2026534722","https://openalex.org/W2027235689","https://openalex.org/W2027345698","https://openalex.org/W2032750779","https://openalex.org/W2034599708","https://openalex.org/W2036161550","https://openalex.org/W2038056279","https://openalex.org/W2038104557","https://openalex.org/W2038152741","https://openalex.org/W2038346120","https://openalex.org/W2038621570","https://openalex.org/W2038662926","https://openalex.org/W2040557992","https://openalex.org/W2041647645","https://openalex.org/W2042548992","https://openalex.org/W2042789528","https://openalex.org/W2043211192","https://openalex.org/W2044575523","https://openalex.org/W2047786096","https://openalex.org/W2049131878","https://openalex.org/W2050566897","https://openalex.org/W2051765186","https://openalex.org/W2052069581","https://openalex.org/W2052181006","https://openalex.org/W2053475652","https://openalex.org/W2054635037","https://openalex.org/W2056250732","https://openalex.org/W2056999782","https://openalex.org/W2057119603","https://openalex.org/W2057907014","https://openalex.org/W2059367931","https://openalex.org/W2059520401","https://openalex.org/W2060328515","https://openalex.org/W2060356815","https://openalex.org/W2061733622","https://openalex.org/W2061824080","https://openalex.org/W2062582838","https://openalex.org/W2063488126","https://openalex.org/W2063773089","https://openalex.org/W2066303397","https://openalex.org/W2067136873","https://openalex.org/W2068859382","https://openalex.org/W2069601502","https://openalex.org/W2070231383","https://openalex.org/W2070806048","https://openalex.org/W2071711966","https://openalex.org/W2072684051","https://openalex.org/W2072746193","https://openalex.org/W2074652739","https://openalex.org/W2074849341","https://openalex.org/W2075093963","https://openalex.org/W2075505893","https://openalex.org/W2077414013","https://openalex.org/W2077730872","https://openalex.org/W2078771835","https://openalex.org/W2078962517","https://openalex.org/W2078983800","https://openalex.org/W2080357830","https://openalex.org/W2086321716","https://openalex.org/W2087202705","https://openalex.org/W2087765372","https://openalex.org/W2088155741","https://openalex.org/W2088338570","https://openalex.org/W2088839023","https://openalex.org/W2089228093","https://openalex.org/W2089689811","https://openalex.org/W2090863707","https://openalex.org/W2094294421","https://openalex.org/W2095505023","https://openalex.org/W2096277540","https://openalex.org/W2096363752","https://openalex.org/W2096763392","https://openalex.org/W2097888801","https://openalex.org/W2098166392","https://openalex.org/W2098553150","https://openalex.org/W2103283253","https://openalex.org/W2104269072","https://openalex.org/W2107040447","https://openalex.org/W2107920117","https://openalex.org/W2108827084","https://openalex.org/W2111642738","https://openalex.org/W2113007722","https://openalex.org/W2113120282","https://openalex.org/W2116064503","https://openalex.org/W2116525597","https://openalex.org/W2116810280","https://openalex.org/W2117795567","https://openalex.org/W2118865435","https://openalex.org/W2120932776","https://openalex.org/W2121395329","https://openalex.org/W2123175723","https://openalex.org/W2123320389","https://openalex.org/W2124239919","https://openalex.org/W2126686907","https://openalex.org/W2128858821","https://openalex.org/W2129826523","https://openalex.org/W2131403822","https://openalex.org/W2131709544","https://openalex.org/W2132189134","https://openalex.org/W2133120422","https://openalex.org/W2133565927","https://openalex.org/W2135395604","https://openalex.org/W2135732933","https://openalex.org/W2137577190","https://openalex.org/W2142684817","https://openalex.org/W2145243474","https://openalex.org/W2145662716","https://openalex.org/W2147051864","https://openalex.org/W2147723850","https://openalex.org/W2148075008","https://openalex.org/W2149507416","https://openalex.org/W2150366608","https://openalex.org/W2158305179","https://openalex.org/W2158749015","https://openalex.org/W2160373896","https://openalex.org/W2162745520","https://openalex.org/W2164633296","https://openalex.org/W2167479783","https://openalex.org/W2168949343","https://openalex.org/W2170413271","https://openalex.org/W2170526559","https://openalex.org/W2171994385","https://openalex.org/W2175702280","https://openalex.org/W2312549654","https://openalex.org/W2312577281","https://openalex.org/W2313915317","https://openalex.org/W2314338374","https://openalex.org/W2315479558","https://openalex.org/W2316481389","https://openalex.org/W2318455200","https://openalex.org/W2320352905","https://openalex.org/W2320801192","https://openalex.org/W2321696191","https://openalex.org/W2322926095","https://openalex.org/W2323574745","https://openalex.org/W2323745647","https://openalex.org/W2324903275","https://openalex.org/W2324978438","https://openalex.org/W2325812897","https://openalex.org/W2325900068","https://openalex.org/W2325976381","https://openalex.org/W2326058958","https://openalex.org/W2327151193","https://openalex.org/W2331195992","https://openalex.org/W2332979226","https://openalex.org/W2414067561","https://openalex.org/W2422720264","https://openalex.org/W2478080782","https://openalex.org/W2495615306","https://openalex.org/W2620176919","https://openalex.org/W2949322055","https://openalex.org/W2949330038","https://openalex.org/W2949642830","https://openalex.org/W2950099764","https://openalex.org/W2950106778","https://openalex.org/W2950347931","https://openalex.org/W2950661474","https://openalex.org/W2951742979","https://openalex.org/W2951889286","https://openalex.org/W2951987461","https://openalex.org/W2952254948","https://openalex.org/W2953167586","https://openalex.org/W3004553178","https://openalex.org/W3145530580","https://openalex.org/W3147520884","https://openalex.org/W3151072331","https://openalex.org/W4253704503","https://openalex.org/W4256503849","https://openalex.org/W6683284789","https://openalex.org/W7074646435"],"related_works":["https://openalex.org/W3033320500","https://openalex.org/W3122145185","https://openalex.org/W3088037118","https://openalex.org/W7100092943","https://openalex.org/W2346721164","https://openalex.org/W4408243130","https://openalex.org/W2951111789","https://openalex.org/W2023018411","https://openalex.org/W4389704958","https://openalex.org/W2027345698"],"abstract_inverted_index":{"Macrocyclic":[0],"scaffolds":[1],"are":[2,114],"commonly":[3,78],"found":[4],"in":[5,39,116],"bioactive":[6],"natural":[7,19,44,105],"products":[8,20,106],"and":[9,24,36,64,93,107,141],"pharmaceutical":[10],"molecules.":[11],"So":[12],"far,":[13],"a":[14,34],"large":[15],"number":[16],"of":[17,28,42,59,74,101,104,122,136,150],"macrocyclic":[18,43,102,130],"have":[21,53,67],"been":[22,54,68],"isolated":[23],"synthesized.":[25],"The":[26,77,119],"construction":[27],"macrocycles":[29,63,109],"is":[30,125],"generally":[31],"considered":[32],"as":[33],"crucial":[35],"challenging":[37],"step":[38],"the":[40,47,57,72,133,143,148],"synthesis":[41,58,103,149],"products.":[45],"Over":[46],"last":[48],"several":[49],"decades,":[50],"numerous":[51],"efforts":[52],"undertaken":[55],"toward":[56,82],"complex":[60],"naturally":[61],"occurring":[62],"great":[65],"progresses":[66],"made":[69],"to":[70,126],"advance":[71],"field":[73],"total":[75],"synthesis.":[76],"used":[79,129],"synthetic":[80,145],"methodologies":[81,146],"macrocyclization":[83],"include":[84],"macrolactonization,":[85],"macrolactamization,":[86],"transition":[87],"metal-catalyzed":[88],"cross":[89],"coupling,":[90],"ring-closing":[91],"metathesis,":[92],"click":[94],"reaction,":[95],"among":[96],"others.":[97],"Selected":[98],"recent":[99],"examples":[100],"druglike":[108],"with":[110],"significant":[111],"biological":[112],"relevance":[113],"highlighted":[115],"each":[117],"class.":[118],"primary":[120],"goal":[121],"this":[123,137],"review":[124],"summarize":[127],"currently":[128],"drugs,":[131],"highlight":[132],"therapeutic":[134],"potential":[135],"underexplored":[138],"drug":[139],"class":[140],"outline":[142],"general":[144],"for":[147],"macrocycles.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
