{"id":"https://openalex.org/W1997005113","doi":"https://doi.org/10.1126/science.175.4018.209","title":"Thyrotropin-Releasing Hormone: Evidence for Thyroid Response to Intravenous Injection in Man","display_name":"Thyrotropin-Releasing Hormone: Evidence for Thyroid Response to Intravenous Injection in Man","publication_year":1972,"publication_date":"1972-01-14","ids":{"openalex":"https://openalex.org/W1997005113","doi":"https://doi.org/10.1126/science.175.4018.209","mag":"1997005113","pmid":"https://pubmed.ncbi.nlm.nih.gov/4621482"},"language":"en","primary_location":{"id":"doi:10.1126/science.175.4018.209","doi":"https://doi.org/10.1126/science.175.4018.209","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.175.4018.209","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110718225","display_name":"Charles S. Hollander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles S. Hollander","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113509453","display_name":"Terunori Mitsuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terunori Mitsuma","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Louis Shenkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis Shenkman","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023725545","display_name":"Paul D. Woolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Woolf","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005079343","display_name":"Marvin Carl Gershengorn","orcid":"https://orcid.org/0000-0001-6256-6470","observed_orcids":["https://orcid.org/0000-0001-6256-6470"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin C. Gershengorn","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.6687,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.98604802,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"175","issue":"4018","first_page":"209","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":1.0},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.793434202671051},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.7711349725723267},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7582173943519592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7558106184005737},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.7528259754180908},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6244686245918274},{"id":"https://openalex.org/C2779571634","wikidata":"https://www.wikidata.org/wiki/Q422106","display_name":"Thyroid hormones","level":3,"score":0.530586838722229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5131168961524963},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.41014426946640015}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.175.4018.209","doi":"https://doi.org/10.1126/science.175.4018.209","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.175.4018.209","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:4621482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4621482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W108045669","https://openalex.org/W1971459605","https://openalex.org/W1980606541","https://openalex.org/W1983261148","https://openalex.org/W1986724218","https://openalex.org/W1991999578","https://openalex.org/W2011939405","https://openalex.org/W2017849700","https://openalex.org/W2030575673","https://openalex.org/W2033781208","https://openalex.org/W2054565909","https://openalex.org/W2060195558","https://openalex.org/W2063694054","https://openalex.org/W2067481959","https://openalex.org/W2092717550","https://openalex.org/W2108002609","https://openalex.org/W2112394557","https://openalex.org/W2122246436","https://openalex.org/W2130799585","https://openalex.org/W2136626320","https://openalex.org/W2412769719","https://openalex.org/W2418977296","https://openalex.org/W2437820287"],"related_works":["https://openalex.org/W2340367026","https://openalex.org/W2038823351","https://openalex.org/W2403329111","https://openalex.org/W2067481959","https://openalex.org/W1991999578","https://openalex.org/W2145102344","https://openalex.org/W2320571074","https://openalex.org/W1984317827","https://openalex.org/W1993697081","https://openalex.org/W2059051641"],"abstract_inverted_index":{"Administration":[0],"of":[1,30,37],"thyrotropin-releasing":[2],"hormone":[3],"to":[4,28,43,45],"normal":[5],"subjects":[6],"causes":[7],"a":[8,17],"prompt":[9],"rise":[10],"in":[11,20,32],"plasma":[12,22],"thyrotropin":[13],"concentration,":[14],"followed":[15],"by":[16],"significant":[18],"increase":[19],"circulating":[21],"triiodothyronine.":[23],"These":[24],"observations":[25],"may":[26],"prove":[27],"be":[29],"value":[31],"simultaneously":[33],"assessing":[34],"the":[35,38],"ability":[36],"pituitary":[39],"and":[40],"thyroid":[41],"glands":[42],"respond":[44],"their":[46],"trophic":[47],"hormones.":[48]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}