{"id":"https://openalex.org/W1996986715","doi":"https://doi.org/10.1007/bf00316367","title":"Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo","display_name":"Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W1996986715","doi":"https://doi.org/10.1007/bf00316367","mag":"1996986715","pmid":"https://pubmed.ncbi.nlm.nih.gov/2764704"},"language":"en","primary_location":{"id":"doi:10.1007/bf00316367","doi":"https://doi.org/10.1007/bf00316367","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00316367","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077026712","display_name":"Stephan Klug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Klug","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108429831","display_name":"J. Creech Kraft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Creech Kraft","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051004799","display_name":"E. Wildi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Wildi","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113466383","display_name":"H.-J. Merker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. -J. Merker","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109770985","display_name":"T. V. N. Persaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T. V. N. Persaud","raw_affiliation_strings":["University of Manitoba, R3POS3, Winnipeg, Manitoba, Canada","University of Manitoba Winnipeg  Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manitoba, R3POS3, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"University of Manitoba Winnipeg  Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109943894","display_name":"Heinz Nau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Nau","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041954527","display_name":"Diether Neubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Neubert","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Garystrasse 5, 1000, Berlin 33","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, Berlin-33","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":null,"fwci":0.9692,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.73563156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"3","first_page":"185","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.847000002861023},{"id":"https://openalex.org/keywords/rat-embryo-culture","display_name":"rat embryo culture","score":0.6230000257492065},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8612295389175415},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6424999237060547},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5980932712554932},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5835638046264648},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5509702563285828},{"id":"https://openalex.org/C126661725","wikidata":"https://www.wikidata.org/wiki/Q903420","display_name":"Isomerization","level":3,"score":0.5244850516319275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5147831439971924},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49825334548950195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4650123715400696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35434865951538086},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32927483320236206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3043573796749115},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00316367","doi":"https://doi.org/10.1007/bf00316367","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00316367","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:2764704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2764704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W104300299","https://openalex.org/W167862209","https://openalex.org/W1985719464","https://openalex.org/W2005292132","https://openalex.org/W2049791242","https://openalex.org/W2053520712","https://openalex.org/W2058605847","https://openalex.org/W2085231416","https://openalex.org/W2092470264","https://openalex.org/W2121628155","https://openalex.org/W2280958579","https://openalex.org/W2337949001","https://openalex.org/W2402187155"],"related_works":["https://openalex.org/W2044032683","https://openalex.org/W2013693833","https://openalex.org/W2121628155","https://openalex.org/W2002810221","https://openalex.org/W2031859484","https://openalex.org/W2083061280","https://openalex.org/W2187495147","https://openalex.org/W2075055416","https://openalex.org/W1963895870","https://openalex.org/W2007703077"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
