{"id":"https://openalex.org/W1996974042","doi":"https://doi.org/10.1016/s0304-3959(02)00301-9","title":"Vagus nerve stimulation in awake rats reduces formalin-induced nociceptive behaviour and fos-immunoreactivity in trigeminal nucleus caudalis","display_name":"Vagus nerve stimulation in awake rats reduces formalin-induced nociceptive behaviour and fos-immunoreactivity in trigeminal nucleus caudalis","publication_year":2002,"publication_date":"2002-12-30","ids":{"openalex":"https://openalex.org/W1996974042","doi":"https://doi.org/10.1016/s0304-3959(02)00301-9","mag":"1996974042","pmid":"https://pubmed.ncbi.nlm.nih.gov/12507695"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3959(02)00301-9","doi":"https://doi.org/10.1016/s0304-3959(02)00301-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3959(02)00301-9","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108601982","display_name":"Catalina Roxana Bohotin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C Bohotin","raw_affiliation_strings":["Department of Neuroanatomy, 20, rue de Pitteurs, B-4020, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy, 20, rue de Pitteurs, B-4020, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040940563","display_name":"Martin Scholsem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Scholsem","raw_affiliation_strings":["Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000014996","display_name":"Sylvie Multon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S Multon","raw_affiliation_strings":["Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069550484","display_name":"Didier Martin","orcid":"https://orcid.org/0000-0001-7325-4958","observed_orcids":["https://orcid.org/0000-0001-7325-4958"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"D Martin","raw_affiliation_strings":["Department of Neurosurgery, CHU-Sart Tilman, B-4000 Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHU-Sart Tilman, B-4000 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073494260","display_name":"Valentin Bohotin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V Bohotin","raw_affiliation_strings":["University Department of Neurology, CHR Citadelle, B-4000 Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Neurology, CHR Citadelle, B-4000 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018653939","display_name":"Jean E. Schoenen","orcid":"https://orcid.org/0000-0002-6506-6460","observed_orcids":["https://orcid.org/0000-0002-6506-6460"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"J Schoenen","raw_affiliation_strings":["Corresponding author. Tel.: +32-4-3665191; fax: +32-4-2256451","Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium","University Department of Neurology, CHR Citadelle, B-4000 Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author. Tel.: +32-4-3665191; fax: +32-4-2256451","institution_ids":[]},{"raw_affiliation_string":"Department of Neuroanatomy, 20, rue de Pitteurs, B-4020 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"University Department of Neurology, CHR Citadelle, B-4000 Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018653939"],"corresponding_institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210159123"],"apc_list":null,"apc_paid":null,"fwci":2.2702,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.85924207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"1","first_page":"3","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"vagus nerve stimulation","score":1.0},{"id":"https://openalex.org/keywords/formalin-induced-nociception","display_name":"formalin-induced nociception","score":0.7820000052452087},{"id":"https://openalex.org/keywords/trigeminal-nucleus-caudalis","display_name":"trigeminal nucleus caudalis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/trigeminal-pain","display_name":"trigeminal pain","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.9200000166893005},{"id":"https://openalex.org/keywords/implantable-neurostimulator","display_name":"implantable neurostimulator","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cervical-vagus-nerve","display_name":"cervical vagus nerve","score":0.671999990940094},{"id":"https://openalex.org/keywords/nociceptor-activation","display_name":"nociceptor activation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.8407467603683472},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.8230306506156921},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7025449872016907},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.5883395075798035},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5556718707084656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5435552000999451},{"id":"https://openalex.org/C2776700747","wikidata":"https://www.wikidata.org/wiki/Q7577476","display_name":"Spinal trigeminal nucleus","level":4,"score":0.4840816557407379},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.4822705388069153},{"id":"https://openalex.org/C2780323455","wikidata":"https://www.wikidata.org/wiki/Q2745522","display_name":"c-Fos","level":4,"score":0.428510844707489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36646243929862976},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3347238600254059},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2102116048336029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20728790760040283},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17363154888153076},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.081451416015625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.04989895224571228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005157","descriptor_name":"Facial Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005157","descriptor_name":"Facial Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014275","descriptor_name":"Trigeminal Caudal Nucleus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014275","descriptor_name":"Trigeminal Caudal Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014275","descriptor_name":"Trigeminal Caudal Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014738","descriptor_name":"Vibrissae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0304-3959(02)00301-9","doi":"https://doi.org/10.1016/s0304-3959(02)00301-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3959(02)00301-9","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:12507695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12507695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/7208","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/7208","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pain, 101 (1-2), 3-12 (2003-01)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W27232454","https://openalex.org/W1535517466","https://openalex.org/W1553486550","https://openalex.org/W1832891917","https://openalex.org/W1965026024","https://openalex.org/W1966048133","https://openalex.org/W1966677629","https://openalex.org/W1972627193","https://openalex.org/W1974389368","https://openalex.org/W1974742465","https://openalex.org/W1975760648","https://openalex.org/W1976430391","https://openalex.org/W1982387055","https://openalex.org/W1982877154","https://openalex.org/W1983108899","https://openalex.org/W1985950337","https://openalex.org/W1989364117","https://openalex.org/W1996397559","https://openalex.org/W1998975902","https://openalex.org/W2001933690","https://openalex.org/W2007150768","https://openalex.org/W2009113851","https://openalex.org/W2009345240","https://openalex.org/W2009559477","https://openalex.org/W2012000347","https://openalex.org/W2014614933","https://openalex.org/W2014911563","https://openalex.org/W2015386391","https://openalex.org/W2018754150","https://openalex.org/W2019251423","https://openalex.org/W2020595768","https://openalex.org/W2021704553","https://openalex.org/W2022857000","https://openalex.org/W2024081721","https://openalex.org/W2025980081","https://openalex.org/W2026124090","https://openalex.org/W2026158396","https://openalex.org/W2027989317","https://openalex.org/W2028612262","https://openalex.org/W2031578133","https://openalex.org/W2031736153","https://openalex.org/W2032229519","https://openalex.org/W2032472489","https://openalex.org/W2037447017","https://openalex.org/W2043012348","https://openalex.org/W2044686423","https://openalex.org/W2045274671","https://openalex.org/W2046761549","https://openalex.org/W2047265728","https://openalex.org/W2047743315","https://openalex.org/W2048102847","https://openalex.org/W2050626408","https://openalex.org/W2055648315","https://openalex.org/W2057697708","https://openalex.org/W2065507184","https://openalex.org/W2069824549","https://openalex.org/W2071947518","https://openalex.org/W2072078964","https://openalex.org/W2075392928","https://openalex.org/W2075921161","https://openalex.org/W2077023159","https://openalex.org/W2078834347","https://openalex.org/W2083865582","https://openalex.org/W2087208730","https://openalex.org/W2087622724","https://openalex.org/W2090142917","https://openalex.org/W2090686529","https://openalex.org/W2093448548","https://openalex.org/W2102785886","https://openalex.org/W2112111910","https://openalex.org/W2115212197","https://openalex.org/W2118284287","https://openalex.org/W2122476633","https://openalex.org/W2132564337","https://openalex.org/W2149837516","https://openalex.org/W2157239778","https://openalex.org/W2169923097","https://openalex.org/W2176807824","https://openalex.org/W2198326176","https://openalex.org/W2220116361","https://openalex.org/W2234794249","https://openalex.org/W2239986950","https://openalex.org/W2260987080","https://openalex.org/W2272627472","https://openalex.org/W2280017322","https://openalex.org/W2306832307","https://openalex.org/W2344168060","https://openalex.org/W2403756261","https://openalex.org/W2411853216","https://openalex.org/W2413611243","https://openalex.org/W2908175543","https://openalex.org/W4231763549","https://openalex.org/W4249377710","https://openalex.org/W6685242360"],"related_works":["https://openalex.org/W2045019513","https://openalex.org/W4300023043","https://openalex.org/W24450281","https://openalex.org/W2104543636","https://openalex.org/W2625824407","https://openalex.org/W1998975902","https://openalex.org/W1966677232","https://openalex.org/W2268630135","https://openalex.org/W2037987300","https://openalex.org/W1978847367"],"abstract_inverted_index":{"Besides":[0],"its":[1],"well-established":[2],"efficacy":[3],"in":[4,15,25,36,42,114,158,161,167,181,244,249,256],"epilepsy,":[5],"vagus":[6],"nerve":[7],"stimulation":[8,33,143],"(VNS)":[9],"may":[10,247],"be":[11],"of":[12,47,81,117,129,177,200,259],"potential":[13],"interest":[14],"pain":[16,27],"treatment.":[17],"It":[18,171],"has,":[19],"however,":[20],"not":[21],"yet":[22],"been":[23],"assessed":[24,97],"animal":[26],"models":[28],"with":[29,240],"the":[30,45,93,104,164,175,190,198,216,225,231],"devices":[31],"and":[32,58,77,102,138,221],"protocols":[34],"used":[35,126,243],"humans.":[37],"We":[38,125],"have":[39,248],"therefore":[40],"studied":[41],"awake":[43,250],"rats":[44,251],"effects":[46],"left":[48,94],"cervical":[49],"VNS":[50,61,132,137,140,148,153,192,206,238],"on":[51,122,194,211],"trigeminal":[52,118,260],"nociception":[53],"using":[54],"an":[55],"implantable":[56],"electrode":[57],"stimulator":[59],"(NCP-Cyberonics).":[60],"was":[62,196,204],"applied":[63,239],"for":[64,99],"24h":[65],"at":[66],"2":[67],"mA":[68],"intensity,":[69],"20":[70],"Hz":[71],"frequency,":[72],"0.5":[73],"ms":[74],"pulse":[75],"width":[76],"a":[78,86,241,252,257],"duty":[79],"cycle":[80],"20s":[82],"ON/18s":[83],"OFF.":[84],"As":[85],"nociceptive":[87,209],"stimulus,":[88],"we":[89],"injected":[90],"formalin":[91,135,187,232],"into":[92],"mystacial":[95],"vibrissae,":[96],"behaviour":[98,210],"45":[100,106],"min":[101,107],"sacrificed":[103],"animals":[105],"later.":[108],"Fos-immunoreactive":[109],"(Fos-Ir)":[110],"neurons":[111,179],"were":[112],"counted":[113],"laminae":[115,184],"I-II":[116,185],"nucleus":[119,168],"caudalis":[120],"(TNC)":[121],"both":[123],"sides.":[124],"three":[127],"groups":[128],"control":[130],"animals:":[131],"without":[133,136,142],"formalin,":[134],"sham":[139,147],"(implanted":[141],"or":[144],"formalin).":[145],"Whereas":[146],"had":[149],"no":[150],"significant":[151,253],"effect,":[152],"alone":[154],"increased":[155],"Fos":[156],"expression":[157],"ipsilateral":[159,182],"TNC":[160,183],"addition":[162],"to":[163],"expected":[165],"increase":[166,176],"tractus":[169],"solitarius.":[170],"also":[172,207],"significantly":[173],"attenuated":[174],"Fos-Ir":[178],"observed":[180],"after":[186,230],"injection.":[188,233],"If":[189],"proper":[191],"effect":[193,255],"Fos-expression":[195],"subtracted,":[197],"reduction":[199],"formalin-induced":[201],"nociceptor":[202],"activation":[203],"55%.":[205],"reduced":[208],"average":[212],"by":[213,222],"96.1%":[214],"during":[215,224],"early":[217],"phase":[218,227],"(0-6":[219],"min)":[220,229],"60.7%":[223],"late":[226],"(6-45":[228],"These":[234],"results":[235],"suggest":[236],"that":[237],"device":[242],"human":[245],"therapy":[246],"antinociceptive":[254],"model":[258],"pain.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}