{"id":"https://openalex.org/W1996973828","doi":"https://doi.org/10.1007/s11481-013-9489-x","title":"Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis","display_name":"Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis","publication_year":2013,"publication_date":"2013-07-24","ids":{"openalex":"https://openalex.org/W1996973828","doi":"https://doi.org/10.1007/s11481-013-9489-x","mag":"1996973828","pmid":"https://pubmed.ncbi.nlm.nih.gov/23881705","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4126425"},"language":"en","primary_location":{"id":"doi:10.1007/s11481-013-9489-x","doi":"https://doi.org/10.1007/s11481-013-9489-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11481-013-9489-x","pdf_url":null,"source":{"id":"https://openalex.org/S137872405","display_name":"Journal of Neuroimmune Pharmacology","issn_l":"1557-1890","issn":["1557-1890","1557-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmune Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4126425","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100694249","display_name":"Weihua Zhao","orcid":"https://orcid.org/0000-0002-5672-7132","observed_orcids":["https://orcid.org/0000-0002-5672-7132"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Zhao","raw_affiliation_strings":["Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048445973","display_name":"David R. Beers","orcid":"https://orcid.org/0000-0002-8757-3500","observed_orcids":["https://orcid.org/0000-0002-8757-3500"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Beers","raw_affiliation_strings":["Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015630437","display_name":"Stanley H. Appel","orcid":"https://orcid.org/0000-0003-2747-6298","observed_orcids":["https://orcid.org/0000-0003-2747-6298"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stanley H. Appel","raw_affiliation_strings":["Department of Neurology, Methodist Neurological Institute, 6560 Fannin Street, Suite 802, Houston, TX, 77030, USA","Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Methodist Neurological Institute, 6560 Fannin Street, Suite 802, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015630437"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":3.1583,"has_fulltext":false,"cited_by_count":300,"citation_normalized_percentile":{"value":0.95269017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"8","issue":"4","first_page":"888","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/m1-m2-microglia","display_name":"M1/M2 microglia","score":0.7310000061988831},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/innate-and-adaptive-immunity","display_name":"innate and adaptive immunity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7429999709129333},{"id":"https://openalex.org/keywords/motor-neuron-injury","display_name":"motor neuron injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/immune-cell-phenotypes","display_name":"immune cell phenotypes","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.8417704105377197},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8153659105300903},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8025398254394531},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7913870215415955},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7609255313873291},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5648808479309082},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5013265609741211},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.465257465839386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41280290484428406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40826940536499023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39550602436065674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3853990435600281},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29234880208969116},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.20793569087982178},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13513699173927307}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11481-013-9489-x","doi":"https://doi.org/10.1007/s11481-013-9489-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11481-013-9489-x","pdf_url":null,"source":{"id":"https://openalex.org/S137872405","display_name":"Journal of Neuroimmune Pharmacology","issn_l":"1557-1890","issn":["1557-1890","1557-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmune Pharmacology","raw_type":"journal-article"},{"id":"pmid:23881705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23881705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4126425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4126425","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neuroimmune Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4126425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4126425","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neuroimmune Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G134305135","display_name":null,"funder_award_id":"NS079943","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3581675020","display_name":"Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS","funder_award_id":"R21NS079943","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W18768637","https://openalex.org/W1012257715","https://openalex.org/W1592831338","https://openalex.org/W1597509827","https://openalex.org/W1931706129","https://openalex.org/W1963947961","https://openalex.org/W1966632624","https://openalex.org/W1976266513","https://openalex.org/W1979480555","https://openalex.org/W1981161212","https://openalex.org/W1981329326","https://openalex.org/W1983060957","https://openalex.org/W1984993201","https://openalex.org/W1987138690","https://openalex.org/W1987495527","https://openalex.org/W1988491332","https://openalex.org/W1999109058","https://openalex.org/W2002104055","https://openalex.org/W2014635801","https://openalex.org/W2015964703","https://openalex.org/W2017808415","https://openalex.org/W2018287616","https://openalex.org/W2019706623","https://openalex.org/W2025504745","https://openalex.org/W2033158384","https://openalex.org/W2033344638","https://openalex.org/W2034254855","https://openalex.org/W2034651824","https://openalex.org/W2036224773","https://openalex.org/W2040891140","https://openalex.org/W2041112741","https://openalex.org/W2049919805","https://openalex.org/W2051387942","https://openalex.org/W2054876142","https://openalex.org/W2058742494","https://openalex.org/W2059355164","https://openalex.org/W2059473556","https://openalex.org/W2063056677","https://openalex.org/W2064875246","https://openalex.org/W2065210647","https://openalex.org/W2066058435","https://openalex.org/W2066094037","https://openalex.org/W2066874059","https://openalex.org/W2068147651","https://openalex.org/W2070542281","https://openalex.org/W2075691498","https://openalex.org/W2076535829","https://openalex.org/W2077331144","https://openalex.org/W2080353159","https://openalex.org/W2080757088","https://openalex.org/W2085185404","https://openalex.org/W2095685454","https://openalex.org/W2104384276","https://openalex.org/W2106178007","https://openalex.org/W2109021011","https://openalex.org/W2109593516","https://openalex.org/W2110289399","https://openalex.org/W2114803648","https://openalex.org/W2119656827","https://openalex.org/W2121396070","https://openalex.org/W2123848058","https://openalex.org/W2124976615","https://openalex.org/W2133950776","https://openalex.org/W2135457495","https://openalex.org/W2135522980","https://openalex.org/W2143373379","https://openalex.org/W2144507462","https://openalex.org/W2150128864","https://openalex.org/W2150523249","https://openalex.org/W2152081764","https://openalex.org/W2154945114","https://openalex.org/W2155779547","https://openalex.org/W2155952912","https://openalex.org/W2157076525","https://openalex.org/W2165276596","https://openalex.org/W2165863447","https://openalex.org/W2166743880","https://openalex.org/W2167912995","https://openalex.org/W2188624248"],"related_works":["https://openalex.org/W2042311402","https://openalex.org/W2158705875","https://openalex.org/W2999201954","https://openalex.org/W2149542236","https://openalex.org/W1982654728","https://openalex.org/W4398209208","https://openalex.org/W2004795162","https://openalex.org/W2257648036","https://openalex.org/W2957539445","https://openalex.org/W2094821183"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
