{"id":"https://openalex.org/W1996917273","doi":"https://doi.org/10.1097/00131746-200509000-00004","title":"A Double-Blind, Placebo-Controlled, Exploratory Trial of Chromium Picolinate in Atypical Depression: Effect on Carbohydrate Craving","display_name":"A Double-Blind, Placebo-Controlled, Exploratory Trial of Chromium Picolinate in Atypical Depression: Effect on Carbohydrate Craving","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W1996917273","doi":"https://doi.org/10.1097/00131746-200509000-00004","mag":"1996917273","pmid":"https://pubmed.ncbi.nlm.nih.gov/16184071"},"language":"en","primary_location":{"id":"doi:10.1097/00131746-200509000-00004","doi":"https://doi.org/10.1097/00131746-200509000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00131746-200509000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060004312","display_name":"John P. Docherty","orcid":"https://orcid.org/0000-0002-7400-8326","observed_orcids":["https://orcid.org/0000-0002-7400-8326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOHN P. DOCHERTY","raw_affiliation_strings":["Comprehensive NeuroScience, Inc., White Plains, NY, USA","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive NeuroScience, Inc., White Plains, NY, USA","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041377151","display_name":"David Allen Sack","orcid":"https://orcid.org/0000-0002-9338-5119","observed_orcids":["https://orcid.org/0000-0002-9338-5119"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210101777","display_name":"Nutrition 21 (United States)","ror":"https://ror.org/01be0e870","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101777"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID A. SACK","raw_affiliation_strings":["DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","institution_ids":["https://openalex.org/I4210101777"]},{"raw_affiliation_string":"SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064278963","display_name":"Mark Roffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210101777","display_name":"Nutrition 21 (United States)","ror":"https://ror.org/01be0e870","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101777"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARK ROFFMAN","raw_affiliation_strings":["DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","institution_ids":["https://openalex.org/I4210101777"]},{"raw_affiliation_string":"SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018977573","display_name":"Manley Finch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210101777","display_name":"Nutrition 21 (United States)","ror":"https://ror.org/01be0e870","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101777"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MANLEY FINCH","raw_affiliation_strings":["DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","institution_ids":["https://openalex.org/I4210101777"]},{"raw_affiliation_string":"SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103421487","display_name":"James R Komorowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210101777","display_name":"Nutrition 21 (United States)","ror":"https://ror.org/01be0e870","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101777"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES R. KOMOROWSKI","raw_affiliation_strings":["DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOCHERTY: Comprehensive NeuroScience, Inc., White Plains, NY and Weill Medical College of Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"FINCH and KOMOROWSKI: Nutrition 21, Inc., Purchase, NY","institution_ids":["https://openalex.org/I4210101777"]},{"raw_affiliation_string":"SACK and ROFFMAN: Comprehensive NeuroScience, Inc., White Plains, NY","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8202,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.95531576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"302","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromium-picolinate","display_name":"chromium picolinate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/atypical-depression","display_name":"atypical depression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbohydrate-craving","display_name":"carbohydrate craving","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.41600000858306885},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.3059999942779541},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.3269999921321869},{"id":"https://openalex.org/keywords/mood-stabilizers","display_name":"mood stabilizers","score":0.31299999356269836},{"id":"https://openalex.org/keywords/placebo-response","display_name":"placebo response","score":0.31700000166893005},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.3880000114440918},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.4390000104904175},{"id":"https://openalex.org/keywords/replication-study","display_name":"replication study","score":0.34700000286102295},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.4580000042915344},{"id":"https://openalex.org/keywords/eating-habits","display_name":"dietary habits","score":0.42500001192092896},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8612937331199646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6528366804122925},{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.6217860579490662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5642131567001343},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5639498233795166},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5408191680908203},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4827655851840973},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4648666977882385},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.37494516372680664},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26672065258026123},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.05990314483642578},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010848","descriptor_name":"Picolinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010848","descriptor_name":"Picolinic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00131746-200509000-00004","doi":"https://doi.org/10.1097/00131746-200509000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00131746-200509000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},{"id":"pmid:16184071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16184071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatric practice","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W35591275","https://openalex.org/W66160768","https://openalex.org/W78097575","https://openalex.org/W115847467","https://openalex.org/W135404249","https://openalex.org/W201058876","https://openalex.org/W207395144","https://openalex.org/W1925684278","https://openalex.org/W1963772921","https://openalex.org/W1965123567","https://openalex.org/W1967000056","https://openalex.org/W1969324905","https://openalex.org/W1969684313","https://openalex.org/W1969822000","https://openalex.org/W1970829787","https://openalex.org/W1972153696","https://openalex.org/W1974134968","https://openalex.org/W1975964541","https://openalex.org/W1982371528","https://openalex.org/W1982950275","https://openalex.org/W1983284282","https://openalex.org/W1983601360","https://openalex.org/W1988895526","https://openalex.org/W2003130956","https://openalex.org/W2003790582","https://openalex.org/W2005469249","https://openalex.org/W2006220912","https://openalex.org/W2006450215","https://openalex.org/W2007212760","https://openalex.org/W2007266882","https://openalex.org/W2008981696","https://openalex.org/W2011548962","https://openalex.org/W2019078949","https://openalex.org/W2022756383","https://openalex.org/W2025085209","https://openalex.org/W2026481380","https://openalex.org/W2031478341","https://openalex.org/W2040581560","https://openalex.org/W2041924199","https://openalex.org/W2048337732","https://openalex.org/W2048904854","https://openalex.org/W2049189688","https://openalex.org/W2050041524","https://openalex.org/W2054446044","https://openalex.org/W2055427699","https://openalex.org/W2062711369","https://openalex.org/W2063127803","https://openalex.org/W2067413318","https://openalex.org/W2070434316","https://openalex.org/W2073526412","https://openalex.org/W2074289124","https://openalex.org/W2078160918","https://openalex.org/W2080182898","https://openalex.org/W2080672792","https://openalex.org/W2080825472","https://openalex.org/W2080993294","https://openalex.org/W2082383524","https://openalex.org/W2083758093","https://openalex.org/W2087902866","https://openalex.org/W2101288743","https://openalex.org/W2104261909","https://openalex.org/W2107955212","https://openalex.org/W2112886079","https://openalex.org/W2119717996","https://openalex.org/W2132399049","https://openalex.org/W2133890809","https://openalex.org/W2140304913","https://openalex.org/W2160584727","https://openalex.org/W2162788755","https://openalex.org/W2166731922","https://openalex.org/W2167761850","https://openalex.org/W2227188615","https://openalex.org/W2284963753","https://openalex.org/W2316829014","https://openalex.org/W2317060418","https://openalex.org/W2397560453","https://openalex.org/W2399083563","https://openalex.org/W3171418018","https://openalex.org/W4245382028"],"related_works":["https://openalex.org/W1970829787","https://openalex.org/W4232326112","https://openalex.org/W1964519313","https://openalex.org/W2089148847","https://openalex.org/W1974134968","https://openalex.org/W2519338538","https://openalex.org/W2093538109","https://openalex.org/W2134225922","https://openalex.org/W2518197199","https://openalex.org/W2017072808"],"abstract_inverted_index":{"BACKGROUND:":[0],":":[1,44,96,327,357],"In":[2,45,149,358,392],"a":[3,333,359,393,483],"small":[4],"pilot":[5],"trial,":[6],"patients":[7,258,279,348,396,407,435,447,466],"with":[8,55,144,195,229,263,349,363,397,409,412,448],"atypical":[9,56,364,449],"depression":[10,57,354,450],"demonstrated":[11,27],"significant":[12,146,175,199,224],"positive":[13],"therapeutic":[14],"response":[15,283],"to":[16,61,461,480],"chromium":[17,38,71,425,442,463,487],"picolinate.":[18],"This":[19],"finding":[20],"is":[21],"of":[22,25,65,118,141,210,246,251,256,320,344,361,367,390,395,416,424,440,471,486],"interest":[23],"because":[24],"the":[26,80,88,98,108,150,178,185,191,208,217,220,230,254,260,277,289,305,377,421],"link":[28],"between":[29,177],"depression,":[30,345,351,365],"decreased":[31],"insulin":[32,40],"sensitivity,":[33],"and":[34,37,87,121,128,164,180,187,243,315,346,387,430,436,474],"subsequent":[35],"diabetes":[36],"picolinate's":[39],"enhancing":[41],"effect.":[42],"METHODS:":[43],"this":[46,417],"double-blind,":[47],"multicenter,":[48],"8-week":[49],"replication":[50],"study,":[51],"113":[52,99],"adult":[53],"outpatients":[54],"were":[58,79,134,159,162,369],"randomized":[59,100],"2:1":[60],"receive":[62],"600":[63,438],"mug/day":[64],"elemental":[66,441],"chromium,":[67],"as":[68,298,300,477,479],"provided":[69],"by":[70],"picolinate":[72],"(CrPic),":[73],"or":[74,342,353,371],"placebo.":[75,413],"Primary":[76],"efficacy":[77,126,193],"measures":[78],"29-item":[81],"Hamilton":[82],"Depression":[83],"Rating":[84],"Scale":[85,93],"(HAM-D-29)":[86],"Clinical":[89],"Global":[90],"Impressions":[91],"Improvement":[92],"(CGI-I).":[94],"RESULTS:":[95],"Of":[97],"patients,":[101],"110":[102],"(70":[103],"CrPic,":[104,131,268],"40":[105],"placebo)":[106,133],"constituted":[107],"intent-to-treat":[109],"(ITT)":[110],"population":[111,262,360],"(i.e.,":[112,136],"received":[113],"at":[114,123,138],"least":[115,124,139],"one":[116,125],"dose":[117,485],"study":[119,142,329,418],"medication":[120],"completed":[122],"evaluation)":[127],"75":[129],"(50":[130],"25":[132],"evaluable":[135,151,188,218],"took":[137],"80%":[140],"drug":[143],"no":[145,174],"protocol":[147],"deviations).":[148],"population,":[152,219],"mean":[153,165,271],"age":[154],"was":[155,170,173,324,426],"46":[156],"years,":[157],"69%":[158],"female,":[160],"81%":[161],"Caucasian,":[163],"body":[166],"mass":[167],"index":[168],"(BMI)":[169],"29.7.":[171],"There":[172],"difference":[176],"CrPic":[179,221,278,373,410],"placebo":[181,231,290,334],"groups":[182,197],"in":[183,216,259,406,433,464],"both":[184,196],"ITT":[186,261],"populations":[189],"on":[190,203,233,284,304,376,427,492],"primary":[192],"measures,":[194],"showing":[198],"improvement":[200,375],"from":[201,226,253],"baseline":[202,227],"total":[204,285],"HAM-D-29":[205,235,286,307,379,402],"scores":[206,287,403],"during":[207],"course":[209],"treatment":[211,323],"(p":[212],"<":[213,296],"0.0001).":[214],"However,":[215],"group":[222,232,291],"showed":[223,275],"improvements":[225,303],"compared":[228,411],"4":[234],"items:":[236,308,380],"appetite":[237,309,381,431,473],"increase,":[238,310,382],"increased":[239,311,383,472],"eating,":[240,312,384],"carbohydrate":[241,265,313,385,399,428,455,475],"craving,":[242,314,386,400],"diurnal":[244,388],"variation":[245,389],"feelings.":[247,391],"A":[248],"supplemental":[249],"analysis":[250],"data":[252],"subset":[255],"41":[257],"high":[264,398],"craving":[266,429,476],"(26":[267],"15":[269],"placebo;":[270],"BMI":[272],"=":[273],"31.1)":[274],"that":[276,420,437],"had":[280],"significantly":[281,301,405],"greater":[282,302],"than":[288],"(65%":[292],"vs.":[293],"33%;":[294],"p":[295],"0.05)":[297],"well":[299,478],"following":[306,378],"genital":[316],"symptoms":[317,470],"(e.g.,":[318],"level":[319],"libido).":[321],"Chromium":[322],"well-tolerated.":[325],"LIMITATIONS:":[326],"The":[328,414],"did":[330,337],"not":[331,338],"include":[332],"run-in":[335],"period,":[336],"require":[339],"minimum":[340],"duration":[341],"severity":[343],"enrolled":[347],"major":[350],"dysthymia,":[352],"NOS.":[355],"CONCLUSIONS:":[356],"adults":[362],"most":[366],"whom":[368],"overweight":[370],"obese,":[372],"produced":[374],"subpopulation":[394],"overall":[401],"improved":[404],"treated":[408],"results":[415],"suggest":[419],"main":[422],"effect":[423,491],"regulation":[432],"depressed":[434,465],"mug":[439],"may":[443],"be":[444],"beneficial":[445],"for":[446,469],"who":[451],"also":[452],"have":[453,489],"severe":[454],"craving.":[456],"Further":[457],"studies":[458],"are":[459],"needed":[460],"evaluate":[462],"specifically":[467],"selected":[468],"determine":[481],"whether":[482],"higher":[484],"would":[488],"an":[490],"mood.":[493]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}