{"id":"https://openalex.org/W1996868898","doi":"https://doi.org/10.1055/s-2008-1081288","title":"Chrysin Induces Hyperalgesia via the GABAAReceptor in Mice","display_name":"Chrysin Induces Hyperalgesia via the GABAAReceptor in Mice","publication_year":2008,"publication_date":"2008-07-09","ids":{"openalex":"https://openalex.org/W1996868898","doi":"https://doi.org/10.1055/s-2008-1081288","mag":"1996868898","pmid":"https://pubmed.ncbi.nlm.nih.gov/18612941"},"language":"en","primary_location":{"id":"doi:10.1055/s-2008-1081288","doi":"https://doi.org/10.1055/s-2008-1081288","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1081288","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055017522","display_name":"Kui Zhai","orcid":"https://orcid.org/0000-0003-4725-190X","observed_orcids":["https://orcid.org/0000-0003-4725-190X"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kui Zhai","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P R China","Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P R China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Hu","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359213","display_name":"Juan Chen","orcid":"https://orcid.org/0000-0002-5407-8239","observed_orcids":["https://orcid.org/0000-0002-5407-8239","https://orcid.org/0009-0009-4828-2653","https://orcid.org/0000-0002-8006-0630"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Chen","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021702791","display_name":"Caiyun Fu","orcid":"https://orcid.org/0000-0003-4090-885X","observed_orcids":["https://orcid.org/0000-0003-4090-885X"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai-yun Fu","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100435668","display_name":"Qiang Chen","orcid":"https://orcid.org/0000-0002-2398-4482","observed_orcids":["https://orcid.org/0000-0002-2398-4482"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Chen","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou, P. R. China","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76214153"],"apc_list":null,"apc_paid":null,"fwci":0.6027,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.70403957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"74","issue":"10","first_page":"1229","last_page":"1234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chrysin","display_name":"chrysin","score":1.0},{"id":"https://openalex.org/keywords/flavones","display_name":"flavones","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.921999990940094},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tail-withdrawal-latency","display_name":"tail withdrawal latency","score":0.722000002861023},{"id":"https://openalex.org/keywords/flumazenil","display_name":"flumazenil","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.9739999771118164},{"id":"https://openalex.org/keywords/picrotoxin","display_name":"picrotoxin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8309999704360962},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2779478871","wikidata":"https://www.wikidata.org/wiki/Q973741","display_name":"Chrysin","level":4,"score":0.9767668843269348},{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.8238629698753357},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7825093269348145},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.6795982718467712},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6675994396209717},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.6599478721618652},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6066404581069946},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.5483000874519348},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.5311146378517151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.529265284538269},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.46638134121894836},{"id":"https://openalex.org/C197711040","wikidata":"https://www.wikidata.org/wiki/Q5910791","display_name":"Hot plate test","level":4,"score":0.45026472210884094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33119118213653564},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28780847787857056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12531059980392456},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0778556764125824},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2008-1081288","doi":"https://doi.org/10.1055/s-2008-1081288","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1081288","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:18612941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18612941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/115791","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/115791","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000711604","https://openalex.org/W950879991","https://openalex.org/W2087326187","https://openalex.org/W1984783825","https://openalex.org/W2076838272","https://openalex.org/W2138424746","https://openalex.org/W1996868898","https://openalex.org/W2467834509","https://openalex.org/W2268817837","https://openalex.org/W2400861285"],"abstract_inverted_index":{"Chrysin":[0],"(5,7-dihydroxyflavone)":[1],"is":[2],"a":[3,82,93,135,152,164,173,193,208,238],"natural":[4],"flavone":[5],"commonly":[6],"found":[7],"in":[8,109,163,196,242],"many":[9],"plants":[10],"including":[11],"PASSIFLORA":[12],"COERULEA":[13],"L.":[14],"Researchers":[15],"have":[16],"performed":[17],"extensive":[18],"and":[19,25,79,123,232,246],"detailed":[20],"investigations":[21],"on":[22,38,43,57],"the":[23,39,46,53,58,62,86,110,158,181,197,243,248],"behavioral":[24],"pharmacological":[26],"effects":[27,112],"of":[28,41,55,70,85,113,161,183,187,235,251],"chrysin":[29,42,56,71,120,162,188,236,252],"IN":[30],"VIVO,":[31],"but":[32],"there":[33],"was":[34,49,121,213],"little":[35],"information":[36],"available":[37],"effect":[40,54,95,160,195,241,250],"nociception.":[44],"Therefore,":[45],"present":[47],"study":[48],"undertaken":[50],"to":[51],"investigate":[52],"nociceptive":[59],"threshold":[60],"using":[61],"tail-immersion":[63,198,244],"test.":[64,199],"Intraperitoneal":[65],"(":[66],"I.":[67,133,150,171,205,220,230],"P.)":[68,206],"injection":[69],"(10,":[72],"25,":[73],"50,":[74],"75,":[75],"100":[76],"mg/kg)":[77,190],"dose-":[78],"time-dependently":[80],"induced":[81,118],"pronounced":[83],"decrease":[84],"tail":[87],"withdrawal":[88],"latencies":[89],"(TWL),":[90],"thus":[91],"characterizing":[92],"hyperalgesic":[94,111,159,194,240,249],"(ED50":[96],"=":[97],"65.59":[98],"mg/kg).":[99],"The":[100,116],"following":[101],"results":[102],"showed":[103,207],"that":[104,228,247],"GABAA":[105,143,153,257],"receptors":[106],"were":[107],"involved":[108],"chrysin.":[114,184],"1)":[115],"hyperalgesia":[117,182],"by":[119,126,216],"significantly":[122],"dose-dependently":[124],"blocked":[125,215],"pretreatment":[127],"with":[128,142,256],"flumazenil":[129,217],"(0.75,":[130],"1":[131],"mg/kg,":[132,149,170,204,219],"P.),":[134,151,172],"specific":[136],"antagonist":[137],"for":[138],"benzodiazepine":[139],"sites":[140],"associated":[141,255],"receptors.":[144,258],"2)":[145],"Bicuculline":[146],"(2,":[147],"4":[148],"receptor":[154],"antagonist,":[155],"markedly":[156],"antagonized":[157],"dose-dependent":[165],"manner.":[166],"3)":[167],"Picrotoxin":[168],"(2":[169],"chloride":[174],"channel":[175],"blocker,":[176],"could":[177],"also":[178,191],"notably":[179],"antagonize":[180],"Oral":[185],"administration":[186,234],"(75":[189],"produced":[192,237],"In":[200,222],"addition,":[201],"diazepam":[202],"(1":[203,218],"marked":[209],"antinociceptive":[210],"effect,":[211],"which":[212],"completely":[214],"P.).":[221],"conclusion,":[223],"it":[224],"can":[225],"be":[226,254],"summarized":[227],"both":[229],"P.":[231],"oral":[233],"significant":[239],"test":[245],"may":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
