{"id":"https://openalex.org/W1996836034","doi":"https://doi.org/10.1167/iovs.10-6476","title":"Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration","display_name":"Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration","publication_year":2011,"publication_date":"2011-03-13","ids":{"openalex":"https://openalex.org/W1996836034","doi":"https://doi.org/10.1167/iovs.10-6476","mag":"1996836034","pmid":"https://pubmed.ncbi.nlm.nih.gov/21398287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3101687"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.10-6476","doi":"https://doi.org/10.1167/iovs.10-6476","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.10-6476","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3101687","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011576250","display_name":"Robert F. Mullins","orcid":"https://orcid.org/0000-0002-5006-0891","observed_orcids":["https://orcid.org/0000-0002-5006-0891"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert F. Mullins","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113467164","display_name":"Micaela N. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micaela N. Johnson","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041587498","display_name":"Elizabeth A. Faidley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Faidley","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037464945","display_name":"Jessica M. Skeie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Skeie","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa; and","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012067697","display_name":"Jian Huang","orcid":"https://orcid.org/0000-0002-5218-9269","observed_orcids":["https://orcid.org/0000-0002-5218-9269"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Huang","raw_affiliation_strings":["Department of Statistics and Actuarial Sciences, University of Iowa, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Actuarial Sciences, University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":16.4505,"has_fulltext":false,"cited_by_count":395,"citation_normalized_percentile":{"value":0.99534011,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"52","issue":"3","first_page":"1606","last_page":"1606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/choriocapillaris","display_name":"choriocapillaris","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drusen","display_name":"drusen","score":0.9240000247955322},{"id":"https://openalex.org/keywords/choroidal-vascular-density","display_name":"choroidal vascular density","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd45-leukocytes","display_name":"CD45+ leukocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2779093074","wikidata":"https://www.wikidata.org/wiki/Q1140528","display_name":"Drusen","level":3,"score":0.9733029007911682},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8840701580047607},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6532476544380188},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5255031585693359},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.4448765814304352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42542994022369385},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.42283719778060913},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35885733366012573}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015593","descriptor_name":"Retinal Drusen","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015593","descriptor_name":"Retinal Drusen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1167/iovs.10-6476","doi":"https://doi.org/10.1167/iovs.10-6476","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.10-6476","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2168567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3101687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3101687","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3101687","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:21398287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21398287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2168567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3101687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2631049162","display_name":"Choriocapillaris Activation in Macular Degeneration","funder_award_id":"R01EY017451","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4121262451","display_name":"Molecular Mechanisms of SOD3 and Oxidative Stress in Diabetic Vitreoretinopathy","funder_award_id":"F32EY022280","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8261756522","display_name":null,"funder_award_id":"EY017451","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306340","display_name":"Foundation Fighting Blindness","ror":"https://ror.org/011728q79"},{"id":"https://openalex.org/F4320309460","display_name":"Macula Vision Research Foundation","ror":"https://ror.org/03cpssz74"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W41398296","https://openalex.org/W91872680","https://openalex.org/W126104546","https://openalex.org/W1505132263","https://openalex.org/W1519481032","https://openalex.org/W1560237148","https://openalex.org/W1576044890","https://openalex.org/W1780202576","https://openalex.org/W1883306593","https://openalex.org/W1965404473","https://openalex.org/W1967043397","https://openalex.org/W1970687916","https://openalex.org/W1974991686","https://openalex.org/W1980954887","https://openalex.org/W1981264477","https://openalex.org/W1985264988","https://openalex.org/W1986301133","https://openalex.org/W1987783857","https://openalex.org/W1992429621","https://openalex.org/W1999383714","https://openalex.org/W2001851506","https://openalex.org/W2012322597","https://openalex.org/W2012585969","https://openalex.org/W2016584341","https://openalex.org/W2018738432","https://openalex.org/W2028350502","https://openalex.org/W2038281158","https://openalex.org/W2039676145","https://openalex.org/W2044141700","https://openalex.org/W2046638324","https://openalex.org/W2054864390","https://openalex.org/W2055981188","https://openalex.org/W2056145235","https://openalex.org/W2056989349","https://openalex.org/W2061444315","https://openalex.org/W2073924928","https://openalex.org/W2076151830","https://openalex.org/W2077366389","https://openalex.org/W2082887801","https://openalex.org/W2084944408","https://openalex.org/W2086188106","https://openalex.org/W2088551743","https://openalex.org/W2101084484","https://openalex.org/W2112564853","https://openalex.org/W2114986656","https://openalex.org/W2117696490","https://openalex.org/W2120618976","https://openalex.org/W2125236492","https://openalex.org/W2127507482","https://openalex.org/W2136501493","https://openalex.org/W2150476698","https://openalex.org/W2151104719","https://openalex.org/W2155236757","https://openalex.org/W2156993091","https://openalex.org/W2161467354","https://openalex.org/W2168912282","https://openalex.org/W2273142706","https://openalex.org/W2407546311","https://openalex.org/W2409685707","https://openalex.org/W2598520882","https://openalex.org/W2724194296","https://openalex.org/W4234378667","https://openalex.org/W4285719527","https://openalex.org/W4300824486"],"related_works":["https://openalex.org/W1576044890","https://openalex.org/W2942553901","https://openalex.org/W2909428613","https://openalex.org/W2919371914","https://openalex.org/W4383559451","https://openalex.org/W4416026528","https://openalex.org/W4403467700","https://openalex.org/W4294796094","https://openalex.org/W4283320504","https://openalex.org/W2742267344"],"abstract_inverted_index":{"PURPOSE:":[0],"Age-related":[1],"macular":[2],"degeneration":[3],"(AMD)":[4],"is":[5],"a":[6,95,120,134,250],"common,":[7],"potentially":[8],"blinding":[9],"disease":[10],"characterized":[11],"by":[12,100],"the":[13,19,36,39,50,59,105,131,220,228],"presence":[14],"of":[15,44,54,58,61,78,84,89,123,130,164,195,230,254],"extracellular":[16],"deposits":[17],"beneath":[18,111,201],"retinal":[20],"pigment":[21],"epithelium":[22],"(RPE).":[23],"Choroidal":[24],"vascular":[25,81,107,128,147,171,199,235],"changes":[26,224],"have":[27],"also":[28],"been":[29],"noted":[30],"in":[31,94,119,138,240],"AMD.":[32,55],"This":[33],"study":[34],"examined":[35],"relationship":[37],"between":[38],"choroidal":[40],"vasculature":[41],"and":[42,46,68,87,98,179,232],"extent":[43],"drusen":[45,112,116,202,212,255],"other":[47,257],"sub-RPE":[48,79,153,183,243],"deposits,":[49,80],"key":[51],"pathologic":[52],"landmarks":[53],"METHODS:":[56],"Sections":[57],"maculas":[60],"45":[62],"human":[63],"eyes":[64],"(21":[65],"early":[66],"AMD":[67,141,231],"24":[69],"age-matched":[70],"control)":[71],"were":[72,92],"evaluated":[73,99,118],"morphometrically.":[74],"The":[75,127,162],"cross-sectional":[76],"area":[77],"density,":[82],"number":[83,88,163],"CD45+":[85],"leukocytes,":[86],"\"ghost":[90],"vessels\"":[91],"determined":[93],"masked":[96],"fashion":[97],"regression":[101,145],"analysis.":[102],"In":[103,192],"addition,":[104],"extramacular":[106,196],"density":[108,129,148,155,172,185,200],"either":[109],"directly":[110],"or":[113,252,256],"adjacent":[114,210],"to":[115,205,211,227,261],"was":[117,149,167,203],"separate":[121],"set":[122],"donor":[124],"eyes.":[125],"RESULTS:":[126],"choriocapillaris":[132],"showed":[133],"trend":[135],"toward":[136],"decreasing":[137],"association":[139,241],"with":[140,152,170,182,242],"status.":[142],"By":[143],"linear":[144],"analysis,":[146],"inversely":[150],"associated":[151],"deposit":[154,184,244,258],"(r(2)":[156,173,186],"=":[157,174,187],"0.22,":[158],"P":[159,176,189],"<":[160,177,190,214],"0.01).":[161,215],"ghost":[165],"vessels":[166],"negatively":[168],"correlated":[169,181],"0.55,":[175],"0.001)":[178],"positively":[180],"0.57,":[188],"0.001).":[191],"morphologic":[193],"studies":[194],"solitary":[197],"drusen,":[198],"found":[204],"be":[206,262],"45%":[207],"lower":[208],"than":[209],"(P":[213],"CONCLUSIONS:":[216],"These":[217],"findings":[218],"support":[219],"concept":[221],"that":[222,234],"microvascular":[223,247],"are":[225,249],"related":[226],"pathogenesis":[229],"suggest":[233],"endothelial":[236],"cell":[237],"loss":[238],"occurs":[239],"formation.":[245],"Whether":[246],"events":[248],"cause":[251],"consequence":[253],"formation":[259],"remains":[260],"determined.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":40},{"year":2020,"cited_by_count":39},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}