{"id":"https://openalex.org/W1996835897","doi":"https://doi.org/10.1126/science.451617","title":"Dissociations Between the Effects of LSD on Behavior and Raphe Unit Activity in Freely Moving Cats","display_name":"Dissociations Between the Effects of LSD on Behavior and Raphe Unit Activity in Freely Moving Cats","publication_year":1979,"publication_date":"1979-08-03","ids":{"openalex":"https://openalex.org/W1996835897","doi":"https://doi.org/10.1126/science.451617","mag":"1996835897","pmid":"https://pubmed.ncbi.nlm.nih.gov/451617"},"language":"en","primary_location":{"id":"doi:10.1126/science.451617","doi":"https://doi.org/10.1126/science.451617","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.451617","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055290548","display_name":"Michael E. Trulson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Trulson","raw_affiliation_strings":["Program in Neurosciences, Department of Psychology, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Neurosciences, Department of Psychology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110364496","display_name":"Barry L. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry L. Jacobs","raw_affiliation_strings":["Program in Neurosciences, Department of Psychology, Princeton University, Princeton, New Jersey 08544"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Neurosciences, Department of Psychology, Princeton University, Princeton, New Jersey 08544","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":null,"apc_paid":null,"fwci":14.3693,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.99107612,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"205","issue":"4405","first_page":"515","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lsd","display_name":"LSD","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lysergic-acid-diethylamide","display_name":"lysergic acid diethylamide","score":0.972000002861023},{"id":"https://openalex.org/keywords/hallucinogens","display_name":"hallucinogens","score":0.8370000123977661},{"id":"https://openalex.org/keywords/serotonergic-neurons","display_name":"serotonergic neurons","score":0.8820000290870667},{"id":"https://openalex.org/keywords/raphe-nuclei","display_name":"raphe nuclei","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neuronal-activity","display_name":"neuronal activity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.6700000166893005},{"id":"https://openalex.org/keywords/behavioral-effects","display_name":"behavioral effects","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8404504060745239},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.8284429311752319},{"id":"https://openalex.org/C2779871769","wikidata":"https://www.wikidata.org/wiki/Q23118","display_name":"Lysergic acid diethylamide","level":4,"score":0.7545866370201111},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.6832903027534485},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.5915831327438354},{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.5320473909378052},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4877232015132904},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4606357514858246},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4332048296928406},{"id":"https://openalex.org/C124315065","wikidata":"https://www.wikidata.org/wiki/Q194270","display_name":"Hallucinogen","level":2,"score":0.4254192113876343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31301647424697876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28445565700531006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2588174343109131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15752047300338745},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12797972559928894}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008238","descriptor_name":"Lysergic Acid Diethylamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.451617","doi":"https://doi.org/10.1126/science.451617","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.451617","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:451617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/451617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W634526638","https://openalex.org/W1483439847","https://openalex.org/W1844018320","https://openalex.org/W1963519950","https://openalex.org/W1965275569","https://openalex.org/W1968647764","https://openalex.org/W1972160704","https://openalex.org/W1975002578","https://openalex.org/W1976636888","https://openalex.org/W2005701415","https://openalex.org/W2006783317","https://openalex.org/W2011049990","https://openalex.org/W2011798603","https://openalex.org/W2011982178","https://openalex.org/W2018481718","https://openalex.org/W2020567239","https://openalex.org/W2028242838","https://openalex.org/W2039078432","https://openalex.org/W2048797702","https://openalex.org/W2117937229","https://openalex.org/W2155528285","https://openalex.org/W2248073267","https://openalex.org/W2271221126","https://openalex.org/W2413879837","https://openalex.org/W2414044005"],"related_works":["https://openalex.org/W1972822274","https://openalex.org/W2049352635","https://openalex.org/W2208233562","https://openalex.org/W2971795816","https://openalex.org/W2006783317","https://openalex.org/W2004307577","https://openalex.org/W2060949542","https://openalex.org/W2011798603","https://openalex.org/W2055043736","https://openalex.org/W2911421883"],"abstract_inverted_index":{"The":[0],"hypothesis":[1],"that":[2],"the":[3,14,25,35,45,51,80,103],"action":[4],"of":[5,13,16,28,37,61,82],"hallucinogenic":[6],"drugs":[7],"is":[8],"mediated":[9],"by":[10,23],"a":[11],"depression":[12,81],"activity":[15,36,70],"brain":[17],"serotonergic":[18],"(raphe)":[19],"neurons":[20,39,89],"was":[21],"tested":[22],"examining":[24],"behavioral":[26,77],"effects":[27],"d-lysergic":[29],"acid":[30],"diethylamide":[31],"(LSD)":[32],"while":[33],"studying":[34],"raphe":[38,68,83,88],"in":[40,67,102],"freely":[41],"moving":[42],"cats.":[43],"Although":[44],"results":[46],"provide":[47],"general":[48],"support":[49],"for":[50],"hypothesis,":[52],"there":[53],"were":[54,90,101],"several":[55],"important":[56],"dissociations.":[57],"(i)":[58],"Low":[59],"doses":[60],"LSD":[62,96],"produced":[63],"only":[64],"small":[65],"decreases":[66],"unit":[69,84],"but":[71],"significant":[72],"behavoiral":[73],"changes;":[74],"(ii)":[75],"LSD-induced":[76],"changes":[78],"outlasted":[79],"activity;":[85],"and":[86],"(iii)":[87],"at":[91],"least":[92],"as":[93,99],"responsive":[94],"to":[95],"during":[97],"tolerance":[98],"they":[100],"nontolerant":[104],"condition.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
