{"id":"https://openalex.org/W1996830776","doi":"https://doi.org/10.3109/10717544.2013.822945","title":"Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood","display_name":"Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood","publication_year":2013,"publication_date":"2013-07-20","ids":{"openalex":"https://openalex.org/W1996830776","doi":"https://doi.org/10.3109/10717544.2013.822945","mag":"1996830776","pmid":"https://pubmed.ncbi.nlm.nih.gov/23869788"},"language":"en","primary_location":{"id":"doi:10.3109/10717544.2013.822945","doi":"https://doi.org/10.3109/10717544.2013.822945","is_oa":true,"landing_page_url":"https://doi.org/10.3109/10717544.2013.822945","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/10717544.2013.822945?needAccess=true","source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/10717544.2013.822945?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044948217","display_name":"Mohammad Intakhab Alam","orcid":"https://orcid.org/0000-0001-9772-0263","observed_orcids":["https://orcid.org/0000-0001-9772-0263"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. Intakhab Alam","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049947030","display_name":"Sanjula Baboota","orcid":"https://orcid.org/0000-0003-1508-6786","observed_orcids":["https://orcid.org/0000-0003-1508-6786"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sanjula Baboota","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077599012","display_name":"Alka Ahuja","orcid":"https://orcid.org/0000-0002-9295-2521","observed_orcids":["https://orcid.org/0000-0002-9295-2521"]},"institutions":[{"id":"https://openalex.org/I197507618","display_name":"Oman Medical College","ror":"https://ror.org/00eckk830","country_code":"OM","type":"healthcare","lineage":["https://openalex.org/I197507618","https://openalex.org/I4405253504"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Alka Ahuja","raw_affiliation_strings":["Pharmacy Department, Oman Medical College P.O. 620, P.C. 130, Azaiba, MuscatOman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Oman Medical College P.O. 620, P.C. 130, Azaiba, MuscatOman","institution_ids":["https://openalex.org/I197507618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100890486","display_name":"Mushir Ali","orcid":"https://orcid.org/0009-0004-4199-9663","observed_orcids":["https://orcid.org/0009-0004-4199-9663"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mushir Ali","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025737605","display_name":"Javed Ali","orcid":"https://orcid.org/0000-0001-5308-0655","observed_orcids":["https://orcid.org/0000-0001-5308-0655"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Javed Ali","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113737300","display_name":"Jasjeet Kaur Sahni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jasjeet K. Sahni","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, Hamdard Nagar, New DelhiIndia","institution_ids":["https://openalex.org/I19716509"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049947030"],"corresponding_institution_ids":["https://openalex.org/I19716509"],"apc_list":{"value":2335,"currency":"GBP","value_usd":2864},"apc_paid":null,"fwci":2.3634,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.84979121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"6","first_page":"247","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9919999837875366},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nose-to-brain-drug-delivery","display_name":"nose-to-brain delivery","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cns-active-drugs","display_name":"CNS-active drugs","score":0.6349999904632568},{"id":"https://openalex.org/keywords/drug-permeation","display_name":"drug permeation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/brain-drug-concentration","display_name":"brain drug concentration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.8957191705703735},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6137663722038269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4938550591468811},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49154481291770935},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.4826255738735199},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.47662198543548584},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.4722420871257782},{"id":"https://openalex.org/C2778801703","wikidata":"https://www.wikidata.org/wiki/Q156104","display_name":"Nasal cavity","level":2,"score":0.4515988230705261},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4362601041793823},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32902804017066956},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2987522482872009},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2814750671386719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13009750843048096},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12401211261749268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11218434572219849},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1111316978931427},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07205510139465332},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.058839231729507446}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10717544.2013.822945","doi":"https://doi.org/10.3109/10717544.2013.822945","is_oa":true,"landing_page_url":"https://doi.org/10.3109/10717544.2013.822945","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/10717544.2013.822945?needAccess=true","source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},{"id":"pmid:23869788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23869788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug delivery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/10717544.2013.822945","doi":"https://doi.org/10.3109/10717544.2013.822945","is_oa":true,"landing_page_url":"https://doi.org/10.3109/10717544.2013.822945","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/10717544.2013.822945?needAccess=true","source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996830776.pdf","grobid_xml":"https://content.openalex.org/works/W1996830776.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W232564400","https://openalex.org/W565368587","https://openalex.org/W1839771938","https://openalex.org/W1976936889","https://openalex.org/W2016587975","https://openalex.org/W2016864853","https://openalex.org/W2027123578","https://openalex.org/W2032465380","https://openalex.org/W2033500231","https://openalex.org/W2034588313","https://openalex.org/W2038622171","https://openalex.org/W2056296871","https://openalex.org/W2068201497","https://openalex.org/W2070156210","https://openalex.org/W2074568185","https://openalex.org/W2076530671","https://openalex.org/W2082301887","https://openalex.org/W2106536537","https://openalex.org/W2113945122","https://openalex.org/W2114179943","https://openalex.org/W2147949566","https://openalex.org/W2165473561","https://openalex.org/W2312429437","https://openalex.org/W2331713002","https://openalex.org/W2931054105","https://openalex.org/W3103518663"],"related_works":["https://openalex.org/W2034588313","https://openalex.org/W2066747137","https://openalex.org/W2331713002","https://openalex.org/W3138364107","https://openalex.org/W7162649188","https://openalex.org/W3215164403","https://openalex.org/W7117958496","https://openalex.org/W4404600948","https://openalex.org/W4288969943","https://openalex.org/W2071239424"],"abstract_inverted_index":{"The":[0,24,50],"present":[1],"study":[2],"was":[3,48,73,91,104,114,124,140],"aimed":[4],"to":[5,67,75,93,142],"evaluate":[6],"the":[7,19,36,79,83,88,121,131,147,152],"nanostrucured":[8],"lipid":[9],"carriers":[10],"(NLC)":[11],"containing":[12,135],"duloxetine":[13],"(DLX-NLC)":[14],"for":[15,65,146,151],"intranasal":[16,138],"infusion":[17,28],"through":[18,137],"nasal":[20,27,80],"cavity":[21,81],"of":[22,38,57,85,98,112,128,133,149,154],"rat.":[23],"in":[25,44,96,116,126],"vivo":[26],"studies":[29],"were":[30,70],"performed":[31],"using":[32],"Wistar":[33],"rats":[34],"and":[35,41,46,55,62,87,118,120],"amount":[37,43,90,111,123],"DLX":[39,72,113,136,150],"permeated":[40,77,89],"its":[42],"brain":[45,119],"blood":[47,117],"estimated.":[49],"effects":[51],"on":[52],"absorption":[53],"rate":[54],"type":[56],"drug":[58,63],"delivery":[59,148],"systems":[60],"(nanocarriers":[61],"solution)":[64],"nose":[66],"brain/blood":[68],"permeation":[69,103],"assessed.":[71],"found":[74,92,141],"be":[76,94,143],"from":[78],"into":[82],"body":[84],"rat":[86],"more":[95],"case":[97,127],"DLX-NLC.":[99,129],"Approximately":[100],"2.5-times":[101],"better":[102],"exhibited":[105],"by":[106],"DLX-NLC":[107],"than":[108],"DLX-solution.":[109],"Appreciable":[110],"estimated":[115,122],"higher":[125],"Thus":[130],"administration":[132],"NLC":[134],"route":[139],"potential":[144],"method":[145],"treatment":[153],"depression.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}