{"id":"https://openalex.org/W1996817698","doi":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","title":"Prazosin in the Treatment of PTSD","display_name":"Prazosin in the Treatment of PTSD","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W1996817698","doi":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","mag":"1996817698","pmid":"https://pubmed.ncbi.nlm.nih.gov/25036580"},"language":"en","primary_location":{"id":"doi:10.1097/01.pra.0000452561.98286.1e","doi":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100610721","display_name":"Ben Green","orcid":"https://orcid.org/0000-0002-3934-3065","observed_orcids":["https://orcid.org/0000-0002-3934-3065"]},"institutions":[{"id":"https://openalex.org/I137265193","display_name":"University of Chester","ror":"https://ror.org/01drpwb22","country_code":"GB","type":"education","lineage":["https://openalex.org/I137265193"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"BEN GREEN","raw_affiliation_strings":["GREEN: University of Chester, Chester, UK","Ben Green, FRCPsych, MB, ChB, Professor of Psychiatry and a Director of the Institute of Medicine, University of Chester, Parkgate Rd, Chester, CH1 4BJ. [email\u00a0protected]","The author declares no conflicts of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GREEN: University of Chester, Chester, UK","institution_ids":["https://openalex.org/I137265193"]},{"raw_affiliation_string":"Ben Green, FRCPsych, MB, ChB, Professor of Psychiatry and a Director of the Institute of Medicine, University of Chester, Parkgate Rd, Chester, CH1 4BJ. [email\u00a0protected]","institution_ids":["https://openalex.org/I137265193"]},{"raw_affiliation_string":"The author declares no conflicts of interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100610721"],"corresponding_institution_ids":["https://openalex.org/I137265193"],"apc_list":null,"apc_paid":null,"fwci":8.2628,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.97338004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"253","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/chronic-ptsd","display_name":"chronic PTSD","score":0.8339999914169312},{"id":"https://openalex.org/keywords/treatment-resistant-ptsd","display_name":"treatment-resistant PTSD","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nightmares","display_name":"nightmares","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.7419999837875366},{"id":"https://openalex.org/keywords/military-personnel","display_name":"military personnel","score":0.6179999709129333},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.6269999742507935},{"id":"https://openalex.org/keywords/alcohol-craving","display_name":"alcohol craving","score":0.6330000162124634},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.987993597984314},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5946280360221863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5130869150161743},{"id":"https://openalex.org/C2991847609","wikidata":"https://www.wikidata.org/wiki/Q202387","display_name":"Posttraumatic stress","level":2,"score":0.4837091565132141},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4364228844642639},{"id":"https://openalex.org/C2781265626","wikidata":"https://www.wikidata.org/wiki/Q1147152","display_name":"Cognitive behavioral therapy","level":3,"score":0.41064274311065674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21306747198104858},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.05373668670654297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058668","descriptor_name":"Adrenergic alpha-1 Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D058668","descriptor_name":"Adrenergic alpha-1 Receptor Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058668","descriptor_name":"Adrenergic alpha-1 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pra.0000452561.98286.1e","doi":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pra.0000452561.98286.1e","pdf_url":null,"source":{"id":"https://openalex.org/S156364528","display_name":"Journal of Psychiatric Practice","issn_l":"1527-4160","issn":["1527-4160","1538-1145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Practice","raw_type":"journal-article"},{"id":"pmid:25036580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25036580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatric practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1974963123","https://openalex.org/W1977611355","https://openalex.org/W2061985356","https://openalex.org/W2066623423","https://openalex.org/W2070376342","https://openalex.org/W2142277208","https://openalex.org/W2160844797","https://openalex.org/W2163047339"],"related_works":["https://openalex.org/W2102520618","https://openalex.org/W2014730180","https://openalex.org/W2598790606","https://openalex.org/W2063229995","https://openalex.org/W2121609794","https://openalex.org/W2115150505","https://openalex.org/W2088993094","https://openalex.org/W3161334603","https://openalex.org/W4248472318","https://openalex.org/W3144202378"],"abstract_inverted_index":{"Posttraumatic":[0],"stress":[1,183],"disorder":[2,11],"(PTSD)":[3],"often":[4],"follows":[5],"a":[6,22,46,114,202,233],"chronic":[7,36],"course,":[8],"and":[9,18,50,59,75,95,163,168,182,231],"the":[10,69,87,101,124,224],"is":[12,110,129,209],"resistant":[13,191],"to":[14,133,179],"treatment":[15,70],"with":[16,108,119,145,166,171,201],"antidepressants":[17],"cognitive-behavioral":[19],"therapy":[20],"in":[21,34,68,161,169,174,195,228],"proportion":[23],"of":[24,40,48,66,71,83,89,103,106,116,136,142,193,215,226],"patients.":[25],"Prazosin,":[26],"an":[27],"a1-adrenoceptor":[28],"blocker,":[29],"has":[30,157],"shown":[31],"some":[32,187],"promise":[33],"treating":[35,93,190],"PTSD.":[37,104],"A":[38],"review":[39],"this":[41],"literature":[42],"was":[43,177],"conducted":[44],"via":[45],"search":[47],"MEDLINE":[49],"SUMMON,":[51],"using":[52],"keywords":[53],"such":[54],"as":[55,219,221,232],"PTSD,":[56,72],"prazosin,":[57],"treatment,":[58],"resistance.":[60],"At":[61],"least":[62],"10":[63],"clinical":[64],"studies":[65,85,222],"prazosin":[67,90,109,216,227],"including":[73],"open-label":[74],"randomized":[76],"controlled":[77],"trials,":[78],"have":[79,147],"been":[80,159],"published.":[81],"All":[82],"these":[84],"support":[86],"efficacy":[88],"either":[91],"for":[92,99,121,189],"nightmares":[94,198],"improving":[96],"sleep":[97],"or":[98],"reducing":[100],"severity":[102],"Treatment":[105],"PTSD":[107,146,167,194,230],"usually":[111],"initiated":[112],"at":[113,139,154],"dose":[115,128],"1":[117],"mg,":[118],"monitoring":[120],"hypotension":[122],"after":[123],"first":[125],"dose.":[126],"The":[127],"then":[130],"gradually":[131],"increased":[132],"maintenance":[134],"levels":[135],"2-6":[137],"mg":[138,153],"night.":[140],"Studies":[141],"military":[143],"patients":[144,170],"used":[148],"higher":[149],"doses":[150],"(e.g.,":[151],"10-16":[152],"night).":[155],"Prazosin":[156,185],"also":[158],"studied":[160],"younger":[162],"older":[164],"adults":[165],"alcohol":[172],"problems,":[173],"whom":[175],"it":[176],"found":[178],"reduce":[180],"cravings":[181],"responses.":[184],"offers":[186],"hope":[188],"cases":[192],"which":[196],"recurrent":[197],"are":[199],"problematic,":[200],"relatively":[203],"rapid":[204],"response":[205],"within":[206],"weeks.":[207],"It":[208],"suggested":[210],"that":[211],"large-scale":[212],"civilian":[213],"trials":[214],"be":[217],"done,":[218],"well":[220],"concerning":[223],"use":[225],"acute":[229],"potential":[234],"preventive":[235],"agent.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}