{"id":"https://openalex.org/W1996790410","doi":"https://doi.org/10.4111/kju.2011.52.12.815","title":"Pilot Study of the Clinical Significance of Serum and Urinary HER-2/neu Protein in Bladder Cancer Patients","display_name":"Pilot Study of the Clinical Significance of Serum and Urinary HER-2/neu Protein in Bladder Cancer Patients","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1996790410","doi":"https://doi.org/10.4111/kju.2011.52.12.815","mag":"1996790410","pmid":"https://pubmed.ncbi.nlm.nih.gov/22216392","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3246512"},"language":"en","primary_location":{"id":"doi:10.4111/kju.2011.52.12.815","doi":"https://doi.org/10.4111/kju.2011.52.12.815","is_oa":true,"landing_page_url":"https://doi.org/10.4111/kju.2011.52.12.815","pdf_url":"http://icurology.org/Synapse/Data/PDFData/0020KJU/kju-52-815.pdf","source":{"id":"https://openalex.org/S189543122","display_name":"Korean journal of urology","issn_l":"0494-4747","issn":["0494-4747","2005-6737","2005-6745","2466-0493","2466-054X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","medline","norway-1","oarl","poland-100","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319435","host_organization_name":"The Korean Urological Association","host_organization_lineage":["https://openalex.org/P4310319435"],"host_organization_lineage_names":["The Korean Urological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://icurology.org/Synapse/Data/PDFData/0020KJU/kju-52-815.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019181360","display_name":"Taek Sang Kim","orcid":"https://orcid.org/0000-0001-9736-1328","observed_orcids":["https://orcid.org/0000-0001-9736-1328"]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taek Sang Kim","raw_affiliation_strings":["Department of Urology, Kosin University College of Medicine, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078223599","display_name":"Hyun Yul Rhew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Yul Rhew","raw_affiliation_strings":["Department of Urology, Kosin University College of Medicine, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091691047","display_name":"Hyunyong Hwang","orcid":"https://orcid.org/0000-0003-0662-3041","observed_orcids":["https://orcid.org/0000-0003-0662-3041"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Yong Hwang","raw_affiliation_strings":["Department of Laboratory Medicine, Kosin University Gospel Hospital, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019181360"],"corresponding_institution_ids":["https://openalex.org/I90735388"],"apc_list":null,"apc_paid":null,"fwci":1.6534,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.82617723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"12","first_page":"815","last_page":"815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.875},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.8899999856948853},{"id":"https://openalex.org/keywords/urine-cytology","display_name":"urine cytology","score":0.652999997138977},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.734000027179718},{"id":"https://openalex.org/keywords/transurethral-resection-of-bladder-tumor","display_name":"transurethral resection of bladder tumor","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9046984314918518},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7301284670829773},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6913522481918335},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6517958641052246},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6501255035400391},{"id":"https://openalex.org/C2777548846","wikidata":"https://www.wikidata.org/wiki/Q7900629","display_name":"Urine cytology","level":4,"score":0.6238256692886353},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.5829559564590454},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4694727659225464},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.46731847524642944},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4650017023086548},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.44877445697784424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4363783299922943},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.4203651249408722},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3764030635356903},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27678465843200684},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4111/kju.2011.52.12.815","doi":"https://doi.org/10.4111/kju.2011.52.12.815","is_oa":true,"landing_page_url":"https://doi.org/10.4111/kju.2011.52.12.815","pdf_url":"http://icurology.org/Synapse/Data/PDFData/0020KJU/kju-52-815.pdf","source":{"id":"https://openalex.org/S189543122","display_name":"Korean journal of urology","issn_l":"0494-4747","issn":["0494-4747","2005-6737","2005-6745","2466-0493","2466-054X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","medline","norway-1","oarl","poland-100","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319435","host_organization_name":"The Korean Urological Association","host_organization_lineage":["https://openalex.org/P4310319435"],"host_organization_lineage_names":["The Korean Urological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Urology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2258803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3246512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22216392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22216392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean journal of urology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3246512","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3246512/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean J Urol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.286.8689","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.286.8689","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1f/62/Korean_J_Urol_2011_Dec_20_52(12)_815-818.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4111/kju.2011.52.12.815","doi":"https://doi.org/10.4111/kju.2011.52.12.815","is_oa":true,"landing_page_url":"https://doi.org/10.4111/kju.2011.52.12.815","pdf_url":"http://icurology.org/Synapse/Data/PDFData/0020KJU/kju-52-815.pdf","source":{"id":"https://openalex.org/S189543122","display_name":"Korean journal of urology","issn_l":"0494-4747","issn":["0494-4747","2005-6737","2005-6745","2466-0493","2466-054X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","medline","norway-1","oarl","poland-100","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319435","host_organization_name":"The Korean Urological Association","host_organization_lineage":["https://openalex.org/P4310319435"],"host_organization_lineage_names":["The Korean Urological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321262","display_name":"Kosin University","ror":"https://ror.org/024b57v39"},{"id":"https://openalex.org/F4320322350","display_name":"College of Medicine, Koisin University","ror":"https://ror.org/024b57v39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996790410.pdf","grobid_xml":"https://content.openalex.org/works/W1996790410.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1819886459","https://openalex.org/W1997936386","https://openalex.org/W2001791004","https://openalex.org/W2030032444","https://openalex.org/W2031934435","https://openalex.org/W2060289355","https://openalex.org/W2069237867","https://openalex.org/W2079620341","https://openalex.org/W2092229345","https://openalex.org/W2137399572","https://openalex.org/W2156958504","https://openalex.org/W2183072962","https://openalex.org/W2189403662","https://openalex.org/W2276418696","https://openalex.org/W2412959608","https://openalex.org/W2436070688"],"related_works":["https://openalex.org/W7100812291","https://openalex.org/W2099762279","https://openalex.org/W2412844198","https://openalex.org/W2081726137","https://openalex.org/W2384647023","https://openalex.org/W4317506833","https://openalex.org/W2157960487","https://openalex.org/W4362571362","https://openalex.org/W2510674277","https://openalex.org/W3155189493"],"abstract_inverted_index":{"PURPOSE:":[0],"HER-2/neu":[1,19,31,71,102,119,128,151,205,222,232,245],"overexpression":[2],"is":[3],"documented":[4],"in":[5,33,62,117,135,142,152,162],"some":[6],"bladder":[7,34,40,80,136,154],"cancers.":[8],"To":[9],"our":[10],"knowledge,":[11],"there":[12],"are":[13],"no":[14,114],"current":[15],"studies":[16],"evaluating":[17],"urine":[18,30,70,95,198],"levels.":[20],"Therefore,":[21],"we":[22],"examined":[23],"the":[24,63,76,121,153,175,192],"clinical":[25,193],"significance":[26],"of":[27,79,149,178,181,243],"serum":[28,68,118],"and":[29,47,50,57,67,69,93,97,107,139,173,186,210],"protein":[32],"cancer.":[35],"MATERIALS":[36],"AND":[37],"METHODS:":[38],"Urothelial":[39],"carcinoma":[41],"patients":[42,138,217],"(n=38,":[43],"including":[44,54,85],"31":[45],"men":[46,56],"7":[48],"women)":[49,59],"healthy":[51,143,163,225],"controls":[52,164],"(n=25,":[53],"20":[55],"5":[58],"were":[60,73,103,158,189,201],"included":[61],"study.":[64],"Urine":[65],"cytology":[66,96,199],"levels":[72,206],"measured":[74],"before":[75],"transurethral":[77],"resection":[78],"tumor":[81,86,90],"procedure.":[82],"Prognostic":[83],"factors":[84],"stage,":[87],"histologic":[88],"grade,":[89],"size,":[91],"multiplicity,":[92],"preoperative":[94,197],"their":[98],"association":[99],"with":[100,203],"urinary":[101,127,150,182,204,221,231,239,244],"analyzed":[104],"by":[105,207],"simple":[106,209],"multiple":[108,211],"regression":[109,212],"analyses.":[110,213],"RESULTS:":[111],"There":[112],"was":[113,129,171],"significant":[115],"difference":[116],"between":[120],"two":[122],"groups":[123],"(p=0.489).":[124],"The":[125,145,241],"mean":[126,146],"7,586.82":[130],"relative":[131],"luminescence":[132],"unit":[133],"(RLU)":[134],"cancer":[137,155,216],"4,245.84":[140],"RLU":[141,147,180],"controls.":[144,226],"values":[148],"patient":[156],"group":[157],"significantly":[159,219],"higher":[160,220],"than":[161,223],"(p=0.012).":[165],"An":[166],"receiver":[167],"operating":[168],"characteristic":[169],"curve":[170],"generated,":[172],"using":[174],"cutoff":[176],"value":[177],"\u22654,800":[179],"HER-2/neu,":[183],"71.1%":[184],"sensitivity":[185],"84.0%":[187],"specificity":[188],"obtained.":[190],"Among":[191],"factors,":[194],"only":[195],"positive":[196],"samples":[200],"associated":[202],"both":[208],"CONCLUSIONS:":[214],"Bladder":[215],"demonstrated":[218],"did":[224],"These":[227],"findings":[228],"suggest":[229],"that":[230],"may":[233],"be":[234],"valuable":[235],"as":[236],"a":[237],"new":[238],"marker.":[240],"application":[242],"needs":[246],"additional":[247],"investigation.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}