{"id":"https://openalex.org/W1996750996","doi":"https://doi.org/10.1089/hyb.1983.2.201","title":"Monoclonal Autoantibody Directed Toward Histone and Capable of Inducing LE Cell Formation","display_name":"Monoclonal Autoantibody Directed Toward Histone and Capable of Inducing LE Cell Formation","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1996750996","doi":"https://doi.org/10.1089/hyb.1983.2.201","mag":"1996750996","pmid":"https://pubmed.ncbi.nlm.nih.gov/6205977"},"language":"en","primary_location":{"id":"doi:10.1089/hyb.1983.2.201","doi":"https://doi.org/10.1089/hyb.1983.2.201","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hyb.1983.2.201","pdf_url":null,"source":{"id":"https://openalex.org/S4210200239","display_name":"Hybridoma","issn_l":"0272-457X","issn":["0272-457X","1554-0014","1557-8348","2168-7897"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059488703","display_name":"Marcia M. Miller","orcid":"https://orcid.org/0000-0001-8721-6338","observed_orcids":["https://orcid.org/0000-0001-8721-6338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARCIA M. MILLER","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979012","display_name":"Ronald M. Goto","orcid":"https://orcid.org/0000-0002-7557-0695","observed_orcids":["https://orcid.org/0000-0002-7557-0695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RONALD GOTO","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113871788","display_name":"M. Laurie Phillips","orcid":"https://orcid.org/0009-0009-0508-5043","observed_orcids":["https://orcid.org/0009-0009-0508-5043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. LAURIE PHILLIPS","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058475688","display_name":"Joan L. Klotz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOAN L. KLOTZ","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011056024","display_name":"Susan D. Clark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SUSAN D. CLARK","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029782037","display_name":"Raymond L. Teplitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RAYMOND L. TEPLITZ","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4725,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62982143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"2","first_page":"201","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-autoantibodies","display_name":"monoclonal autoantibodies","score":0.9330000281333923},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.8209999799728394},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nzb-w-f1-mice","display_name":"NZB/W F1 mice","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chromatin-staining","display_name":"chromatin staining","score":0.6359999775886536},{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/histone-h2a","display_name":"histone H2A","score":0.8519999980926514},{"id":"https://openalex.org/keywords/histone-h2b","display_name":"histone H2B","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-h3","display_name":"histone H3","score":1.0},{"id":"https://openalex.org/keywords/histone-h4","display_name":"histone H4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autoantibody-cross-reactivity","display_name":"autoantibody cross-reactivity","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.746209979057312},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.727779746055603},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6789600253105164},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5997580289840698},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5567655563354492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.547939658164978},{"id":"https://openalex.org/C2993140218","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Immunoelectron microscopy","level":3,"score":0.5395836234092712},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4357500374317169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3477979600429535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2691875100135803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1522921919822693},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08088111877441406}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008814","descriptor_name":"Mice, Inbred NZB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hyb.1983.2.201","doi":"https://doi.org/10.1089/hyb.1983.2.201","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hyb.1983.2.201","pdf_url":null,"source":{"id":"https://openalex.org/S4210200239","display_name":"Hybridoma","issn_l":"0272-457X","issn":["0272-457X","1554-0014","1557-8348","2168-7897"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"journal-article"},{"id":"pmid:6205977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6205977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1485518974","https://openalex.org/W1496775456","https://openalex.org/W1530723120","https://openalex.org/W1966229090","https://openalex.org/W1968947138","https://openalex.org/W1974869964","https://openalex.org/W1975738980","https://openalex.org/W1980743785","https://openalex.org/W1998634984","https://openalex.org/W2001054565","https://openalex.org/W2006216882","https://openalex.org/W2014753556","https://openalex.org/W2031649725","https://openalex.org/W2071176587","https://openalex.org/W2072145209","https://openalex.org/W2073536631","https://openalex.org/W2098489292","https://openalex.org/W2100837269","https://openalex.org/W2101948512","https://openalex.org/W2140856730","https://openalex.org/W2145466529","https://openalex.org/W4313376993"],"related_works":["https://openalex.org/W2140522164","https://openalex.org/W2125225435","https://openalex.org/W1581458819","https://openalex.org/W2010941357","https://openalex.org/W2021411558","https://openalex.org/W1938862221","https://openalex.org/W2085706180","https://openalex.org/W2010664601","https://openalex.org/W2023754297","https://openalex.org/W2042773774"],"abstract_inverted_index":{"LE":[0,43],"cell":[1,31,35,44],"formation":[2,45],"is":[3,20],"one":[4],"feature":[5],"of":[6,15,23,25,30,41,58,69,74,77,93,109,115,130,151],"systemic":[7],"lupus":[8],"erythematosus":[9],"exhibited":[10],"by":[11,162],"virtually":[12],"all":[13],"mice":[14],"the":[16,21,56,70,86,100,121,156],"NZB/NZW":[17,60],"strain":[18],"and":[19,80,105,127,137],"result":[22],"accumulation":[24],"antibodies":[26,39,101,122],"directed":[27,124],"against":[28,125],"components":[29],"nuclei.":[32,96],"A":[33],"hybrid":[34],"line":[36],"which":[37],"produces":[38],"capable":[40,129],"inducing":[42],"in":[46,51,72,102,106],"vitro":[47],"has":[48],"been":[49],"isolated":[50,95],"a":[52,75],"hybridoma":[53],"fusion":[54],"using":[55,99],"splenocytes":[57],"unimmunized":[59],"mice.":[61],"These":[62],"monoclonal":[63,153],"autoantibodies":[64,145],"provide":[65],"an":[66],"intense":[67],"staining":[68],"chromatin":[71],"cells":[73],"number":[76],"divergent":[78],"species":[79],"tissues.":[81],"They":[82],"bind":[83],"strongly":[84],"to":[85,143],"histone":[87,118,147],"rich":[88],"(2":[89],"M":[90],"NaCl)":[91],"fraction":[92],"extracted,":[94],"Further":[97],"analyses":[98],"immune":[103],"precipitations":[104],"antibody":[107],"labeling":[108],"capillary":[110],"blots":[111],"on":[112],"nitrocellulose":[113],"sheets":[114],"calf":[116],"thymus":[117],"demonstrate":[119],"that":[120],"are":[123,128],"histones":[126,139],"reacting":[131],"with":[132,146,155],"H1,":[133],"H2a,":[134],"H2b,":[135],"H3,":[136],"H4":[138],"individually.":[140],"In":[141],"contrast":[142],"human":[144],"specificity,":[148],"no":[149],"cross-reactivity":[150],"this":[152],"autoantibody":[154],"lymphocyte":[157],"surface":[158],"could":[159],"be":[160],"detected":[161],"either":[163],"immunofluorescence":[164],"or":[165],"immunoelectron":[166],"microscopy.":[167]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}