{"id":"https://openalex.org/W1996731338","doi":"https://doi.org/10.1089/dna.1993.12.589","title":"Isolation of Drosophila CREB-B: A Novel CRE-Binding Protein","display_name":"Isolation of Drosophila CREB-B: A Novel CRE-Binding Protein","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1996731338","doi":"https://doi.org/10.1089/dna.1993.12.589","mag":"1996731338","pmid":"https://pubmed.ncbi.nlm.nih.gov/8397816"},"language":"en","primary_location":{"id":"doi:10.1089/dna.1993.12.589","doi":"https://doi.org/10.1089/dna.1993.12.589","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.1993.12.589","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032612272","display_name":"Takeshi Usui","orcid":"https://orcid.org/0000-0002-8301-6766","observed_orcids":["https://orcid.org/0000-0002-8301-6766"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TAKESHI USUI","raw_affiliation_strings":["Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080940844","display_name":"Sarah M. Smolik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SARAH M. SMOLIK","raw_affiliation_strings":["","Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110639865","display_name":"Richard H. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD H. GOODMAN","raw_affiliation_strings":["","Vollum Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Vollum Institute","institution_ids":["https://openalex.org/I2802707198"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1287,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.37637144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"7","first_page":"589","last_page":"595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cre-binding-protein","display_name":"CRE-binding protein","score":0.7770000100135803},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.6579999923706055},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/leucine-zipper-domain","display_name":"leucine zipper domain","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.828000009059906},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.8569999933242798},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gene-family","display_name":"gene family","score":0.550000011920929},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.5600000023841858},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C156860981","wikidata":"https://www.wikidata.org/wiki/Q2565229","display_name":"Leucine zipper","level":4,"score":0.8535873293876648},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8368849754333496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8041006922721863},{"id":"https://openalex.org/C157880135","wikidata":"https://www.wikidata.org/wiki/Q17832633","display_name":"ATF3","level":5,"score":0.676062285900116},{"id":"https://openalex.org/C199172495","wikidata":"https://www.wikidata.org/wiki/Q21116771","display_name":"CREB1","level":5,"score":0.6568521857261658},{"id":"https://openalex.org/C19408993","wikidata":"https://www.wikidata.org/wiki/Q24784063","display_name":"bZIP domain","level":5,"score":0.6374974846839905},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6108411550521851},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6031708121299744},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5071237087249756},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.4884416162967682},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.4735880494117737},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4444124102592468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4428532123565674},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42556607723236084},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.41534459590911865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3537950813770294},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.26350128650665283},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22669214010238647},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/dna.1993.12.589","doi":"https://doi.org/10.1089/dna.1993.12.589","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.1993.12.589","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},{"id":"pmid:8397816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8397816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2259204713","display_name":"Receptors and Signaling in Neuroendocrine Systems","funder_award_id":"P01DK044239","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G52176099","display_name":null,"funder_award_id":"DK44239","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W30701984","https://openalex.org/W1495237614","https://openalex.org/W1533422392","https://openalex.org/W1549983991","https://openalex.org/W1604033113","https://openalex.org/W1756567331","https://openalex.org/W1776052968","https://openalex.org/W1958327809","https://openalex.org/W1962202601","https://openalex.org/W1974014686","https://openalex.org/W1983096415","https://openalex.org/W1996339709","https://openalex.org/W2000024512","https://openalex.org/W2003330976","https://openalex.org/W2005393972","https://openalex.org/W2006491153","https://openalex.org/W2014908429","https://openalex.org/W2021334674","https://openalex.org/W2023666553","https://openalex.org/W2028242823","https://openalex.org/W2033215389","https://openalex.org/W2047029758","https://openalex.org/W2051610691","https://openalex.org/W2071140879","https://openalex.org/W2071500474","https://openalex.org/W2077088537","https://openalex.org/W2091024601","https://openalex.org/W2094807913","https://openalex.org/W2109399660","https://openalex.org/W2129327954","https://openalex.org/W2142611091","https://openalex.org/W2143275370","https://openalex.org/W2144393631","https://openalex.org/W2154697657","https://openalex.org/W2157934217","https://openalex.org/W2168847939","https://openalex.org/W2184637409"],"related_works":["https://openalex.org/W2184637409","https://openalex.org/W2148609464","https://openalex.org/W1979611100","https://openalex.org/W2122678951","https://openalex.org/W2213239053","https://openalex.org/W2000024512","https://openalex.org/W2153724035","https://openalex.org/W2067531311","https://openalex.org/W4236918960","https://openalex.org/W3132287518"],"abstract_inverted_index":{"CREB":[0,18,48,136,184,224],"is":[1,49,106,164,216],"a":[2,28,34,38,66,103,117,122,142,152],"DNA-binding":[3,30],"protein":[4,19,118],"that":[5,45,55,105,220,231,246],"stimulates":[6],"gene":[7,137,237],"transcription":[8,53],"upon":[9],"activation":[10,25],"of":[11,21,33,51,69,78,99,133,146,175,214,221,234,253],"the":[12,46,59,72,76,80,97,134,168,172,180,190,199,235,254],"cAMP":[13,60],"signaling":[14],"pathway.":[15],"The":[16,211],"mammalian":[17,47,176,183,223],"consists":[20],"an":[22,130],"amino-terminal":[23],"transcriptional":[24],"domain":[26,31],"and":[27,37,163,182,196,225,242,245],"carboxy-terminal":[29],"comprised":[32],"basic":[35],"region":[36,170,213],"leucine":[39],"zipper.":[40],"Recent":[41],"studies":[42],"have":[43,93,114],"shown":[44],"one":[50],"many":[52],"factors":[54],"can":[56],"bind":[57],"to":[58,95,108,171],"regulated":[61],"enhancer":[62],"(CRE)":[63],"sequence.":[64,155],"Consequently,":[65],"complete":[67],"understanding":[68],"regulation":[70],"through":[71],"CRE":[73,154],"sequence":[74],"requires":[75],"elucidation":[77],"how":[79],"various":[81],"CRE-binding":[82,100],"proteins":[83,101,207],"interact":[84],"with":[85,151],"each":[86],"other.":[87],"To":[88],"accomplish":[89],"this":[90],"goal,":[91],"we":[92,128],"begun":[94],"characterize":[96],"family":[98],"in":[102,193,240],"system":[104],"amenable":[107],"genetic":[109],"manipulations,":[110],"Drosophila":[111,123,135,148],"melanogaster.":[112],"We":[113],"previously":[115],"cloned":[116],"designated":[119],"dCREB-A":[120,191],"from":[121,189,219,250],"embryonic":[124,241],"cDNA":[125],"library.":[126],"Here,":[127],"describe":[129],"additional":[131],"member":[132],"family,":[138],"isolated":[139],"by":[140],"screening":[141],"lambda":[143],"gt11":[144],"library":[145],"adult":[147,243],"head":[149],"cDNAs":[150],"multimerized":[153],"This":[156],"protein,":[157],"dCREB-B,":[158],"contains":[159],"285":[160],"amino":[161],"acids":[162],"remarkably":[165],"similar":[166],"within":[167],"basic/zipper":[169],"corresponding":[173],"portion":[174],"CREB.":[177],"In":[178],"contrast,":[179],"dCREB-B":[181,215,236],"zipper":[185,192],"domains":[186,203],"differ":[187],"considerably":[188],"both":[194,222,251],"length":[195],"composition.":[197],"However,":[198],"putative":[200],"DNA":[201],"binding":[202],"for":[204],"all":[205],"three":[206],"are":[208,238],"highly":[209],"conserved.":[210],"activator":[212],"completely":[217],"different":[218],"dCREB-A.":[226],"Northern":[227],"blot":[228],"analysis":[229],"shows":[230],"multiple":[232],"transcripts":[233,248],"expressed":[239],"tissues":[244],"these":[247],"arise":[249],"strands":[252],"DNA.(ABSTRACT":[255],"TRUNCATED":[256],"AT":[257],"250":[258],"WORDS)":[259]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
