{"id":"https://openalex.org/W1996728965","doi":"https://doi.org/10.1042/bj3500757","title":"Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase","display_name":"Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase","publication_year":2000,"publication_date":"2000-09-08","ids":{"openalex":"https://openalex.org/W1996728965","doi":"https://doi.org/10.1042/bj3500757","mag":"1996728965","pmid":"https://pubmed.ncbi.nlm.nih.gov/10970789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1221307"},"language":"en","primary_location":{"id":"doi:10.1042/bj3500757","doi":"https://doi.org/10.1042/bj3500757","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3500757","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/350/3/757/703392/bj3500757.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067221681","display_name":"Yoshiyuki Mizushina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiyuki MIZUSHINA","raw_affiliation_strings":["Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113553041","display_name":"Akira Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira IIDA","raw_affiliation_strings":["Graduate School of Pharmacutical Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmacutical Science, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063369452","display_name":"Keisuke Ohta","orcid":"https://orcid.org/0000-0002-2040-5297","observed_orcids":["https://orcid.org/0000-0002-2040-5297"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keisuke OHTA","raw_affiliation_strings":["Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036936109","display_name":"Fumio Sugawara","orcid":"https://orcid.org/0000-0002-5419-2955","observed_orcids":["https://orcid.org/0000-0002-5419-2955"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Fumio SUGAWARA","raw_affiliation_strings":["Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043543625","display_name":"Kengo Sakaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kengo SAKAGUCHI","raw_affiliation_strings":["Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036936109","https://openalex.org/A5043543625","https://openalex.org/A5063369452","https://openalex.org/A5067221681"],"corresponding_institution_ids":["https://openalex.org/I161296585"],"apc_list":null,"apc_paid":null,"fwci":3.0634,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.91172542,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"350","issue":"3","first_page":"757","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":1.0},{"id":"https://openalex.org/keywords/dna-polymerase-alpha","display_name":"DNA polymerase alpha","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":1.0},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.9120000004768372},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hiv-reverse-transcriptase","display_name":"HIV reverse transcriptase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dna-binding-sites","display_name":"DNA binding sites","score":0.671999990940094},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.835964560508728},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.6815274357795715},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6753343939781189},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6431769728660583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6132469177246094},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.597221851348877},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5736137628555298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5633089542388916},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.5409669876098633},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.2196427285671234},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1576327383518219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11110284924507141}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj3500757","doi":"https://doi.org/10.1042/bj3500757","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3500757","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1042/0264-6021:3500757","doi":"https://doi.org/10.1042/0264-6021:3500757","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3500757","pdf_url":"https://portlandpress.com/biochemj/article-pdf/350/3/757/703392/bj3500757.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:10970789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10970789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1221307","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1221307/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/0264-6021:3500757","doi":"https://doi.org/10.1042/0264-6021:3500757","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3500757","pdf_url":"https://portlandpress.com/biochemj/article-pdf/350/3/757/703392/bj3500757.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996728965.pdf","grobid_xml":"https://content.openalex.org/works/W1996728965.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1205465279","https://openalex.org/W1479854695","https://openalex.org/W1546644463","https://openalex.org/W1554339438","https://openalex.org/W1575016271","https://openalex.org/W1674764723","https://openalex.org/W1947815987","https://openalex.org/W1966600801","https://openalex.org/W1966839649","https://openalex.org/W1970574525","https://openalex.org/W1987561504","https://openalex.org/W1988751349","https://openalex.org/W1999347108","https://openalex.org/W2000971601","https://openalex.org/W2009434337","https://openalex.org/W2010481489","https://openalex.org/W2021724905","https://openalex.org/W2022983073","https://openalex.org/W2031083024","https://openalex.org/W2037698292","https://openalex.org/W2044930389","https://openalex.org/W2052524715","https://openalex.org/W2069770293","https://openalex.org/W2075371890","https://openalex.org/W2114918609","https://openalex.org/W2409410477","https://openalex.org/W4233567369"],"related_works":["https://openalex.org/W2030453005","https://openalex.org/W2409410477","https://openalex.org/W2089459455","https://openalex.org/W2074492585","https://openalex.org/W2105296759","https://openalex.org/W2464588739","https://openalex.org/W2032441027","https://openalex.org/W2073496012","https://openalex.org/W2062139885","https://openalex.org/W1971340520"],"abstract_inverted_index":{"As":[0],"described":[1],"previously,":[2],"we":[3,83],"found":[4],"that":[5,57,85,210,234],"new":[6],"triterpenoid":[7],"compounds,":[8],"designated":[9],"fomitellic":[10,222],"acids":[11,223],"A":[12,255],"and":[13,25,37,48,56,71,77,102,107,109,119,156,176,186,197,256,271],"B,":[14],"which":[15,244],"selectively":[16],"inhibit":[17],"the":[18,131,180,218,238,247,260],"activities":[19,132],"of":[20,66,87,93,133,172,183,192,221,235,241,262,269],"mammalian":[21,165],"DNA":[22,68,95,99,104,116,135,141,146,166,173,184,187],"polymerases":[23,136,185],"alpha":[24],"beta":[26,101],"[Mizushina,":[27],"Tanaka,":[28,44],"Kitamura,":[29,45],"Tamai,":[30],"Ikeda,":[31],"Takemura,":[32],"Sugawara,":[33],"Arai,":[34],"Matsukage,":[35],"Yoshida":[36],"Sakaguchi":[38,49],"(1998)":[39,50],"Biochem.":[40],"J.":[41,51],"330,":[42],"1325-1332;":[43],"Mizushina,":[46],"Sugawara":[47],"Nat.":[52],"Prod.":[53],"61,":[54],"193-197]":[55],"a":[58],"known":[59],"triterpenoid,":[60],"ursolic":[61,236,257],"acid,":[62,237],"is":[63],"an":[64],"inhibitor":[65],"human":[67,103,120,151],"topoisomerases":[69,105,174],"I":[70,106,143,175],"II":[72,118,177],"(A.":[73],"Iida,":[74],"Y.":[75],"Mizushina":[76],"K.":[78],"Sakaguchi,":[79],"unpublished":[80],"work).":[81],"Here":[82],"report":[84],"all":[86],"these":[88,126,215],"triterpenoids":[89,161,203],"are":[90],"potent":[91],"inhibitors":[92,168,171],"calf":[94],"polymerase":[96,100,117,142,155,167],"alpha,":[97],"rat":[98],"II,":[108],"show":[110],"moderate":[111],"inhibitory":[112],"effects":[113],"on":[114,214],"plant":[115],"immunodeficiency":[121],"virus":[122],"reverse":[123],"transcriptase.":[124],"However,":[125],"compounds":[127],"did":[128,204],"not":[129,163,205],"influence":[130],"prokaryotic":[134],"such":[137,149],"as":[138,150],"Escherichia":[139],"coli":[140],"or":[144],"other":[145],"metabolic":[147],"enzymes":[148],"telomerase,":[152],"T7":[153],"RNA":[154],"bovine":[157],"deoxyribonuclease":[158],"I.":[159],"These":[160,202],"were":[162,224],"only":[164],"but":[169],"also":[170],"even":[178],"though":[179],"enzymic":[181],"characteristics":[182],"topoisomerases,":[188],"including":[189],"their":[190],"modes":[191],"action,":[193],"amino":[194],"acid":[195,254,258],"sequences":[196],"three-dimensional":[198,219],"structures,":[199],"differed":[200],"markedly.":[201],"bind":[206],"to":[207,229,233],"DNA,":[208],"suggesting":[209],"they":[211],"act":[212],"directly":[213],"enzymes.":[216],"Because":[217],"structures":[220],"shown":[225],"by":[226],"computer":[227],"simulation":[228],"be":[230,250],"very":[231,251],"similar":[232],"DNA-binding":[239],"sites":[240],"both":[242],"enzymes,":[243],"compete":[245],"for":[246],"inhibitors,":[248],"might":[249],"similar.":[252],"Fomitellic":[253],"prevented":[259],"growth":[261],"NUGC":[263],"cancer":[264],"cells,":[265],"with":[266],"LD(50)":[267],"values":[268],"38":[270],"30":[272],"microM":[273],"respectively.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
