{"id":"https://openalex.org/W1996710864","doi":"https://doi.org/10.1093/intimm/4.5.615","title":"Evidence of endogenous regulatory function of transforming growth factor-\u03b21 in experimental allergic encephalomyelitis","display_name":"Evidence of endogenous regulatory function of transforming growth factor-\u03b21 in experimental allergic encephalomyelitis","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1996710864","doi":"https://doi.org/10.1093/intimm/4.5.615","mag":"1996710864","pmid":"https://pubmed.ncbi.nlm.nih.gov/1378298"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/4.5.615","doi":"https://doi.org/10.1093/intimm/4.5.615","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.5.615","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021514185","display_name":"Michael K. Racke","orcid":"https://orcid.org/0000-0002-1231-4694","observed_orcids":["https://orcid.org/0000-0002-1231-4694"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael K. Racke","raw_affiliation_strings":["Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111821370","display_name":"Barbara Cannella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Cannella","raw_affiliation_strings":["Division of Neuropathology, Albert Einstein College of MedicineBronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, Albert Einstein College of MedicineBronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039237147","display_name":"Paul S. Albert","orcid":"https://orcid.org/0000-0003-1658-1068","observed_orcids":["https://orcid.org/0000-0003-1658-1068"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Albert","raw_affiliation_strings":["Biometry and Field Studies Branch, National Institute of Health, Neurological Diseases and Stroke National Institutes of HealthBethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometry and Field Studies Branch, National Institute of Health, Neurological Diseases and Stroke National Institutes of HealthBethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108192090","display_name":"Michael B. Sporn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Sporn","raw_affiliation_strings":["Laboratory of Chemoprevention, National Cancer Institute, National Institutes of HealthBethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemoprevention, National Cancer Institute, National Institutes of HealthBethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057467113","display_name":"Cedric S. Raine","orcid":"https://orcid.org/0000-0001-9567-1963","observed_orcids":["https://orcid.org/0000-0001-9567-1963"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cedric S. Raine","raw_affiliation_strings":["Division of Neuropathology, Albert Einstein College of MedicineBronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, Albert Einstein College of MedicineBronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111837570","display_name":"Dale E. McFarlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dale E. McFarlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":7.403,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.97620641,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"5","first_page":"615","last_page":"620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8920000195503235},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.640999972820282},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9459999799728394},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.8399999737739563},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.7403169870376587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6740267872810364},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.6648432016372681},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6342743635177612},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5989159941673279},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5609728693962097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5514262914657593},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5294007062911987},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5234017968177795},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5156041979789734},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5065821409225464},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.4978001117706299},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.44131746888160706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11536887288093567}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/intimm/4.5.615","doi":"https://doi.org/10.1093/intimm/4.5.615","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.5.615","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmid:1378298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1378298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4444839156","display_name":null,"funder_award_id":"NS-11920","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7145618491","display_name":"EM CYTOPATHOLOGY OF AUTOIMMUNE DEMYELINATION","funder_award_id":"R01NS008952","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1906640112","https://openalex.org/W2072798331","https://openalex.org/W1898802354","https://openalex.org/W1971545951","https://openalex.org/W1681118831","https://openalex.org/W2353921081","https://openalex.org/W2068230018","https://openalex.org/W4312945016","https://openalex.org/W2107207493","https://openalex.org/W2350786480"],"abstract_inverted_index":{"Experimental":[0],"allergic":[1],"encephalomyelitis":[2],"(EAE)":[3],"is":[4,61],"an":[5],"autoimmune":[6],"disease":[7,93],"characterized":[8],"by":[9,47,72],"inflammation":[10,80],"and":[11,84,105],"demyelination":[12],"in":[13,40,64,74,81,121,125],"the":[14,34,41,48,65,92,100,122],"central":[15,77],"nervous":[16,78],"system":[17,79],"(CNS).":[18],"Administration":[19],"of":[20,37,43,50,76,89,99,103,118],"transforming":[21],"growth":[22],"factor-beta":[23],"(TGF-beta)":[24],"has":[25],"been":[26],"shown":[27],"to":[28,96],"inhibit":[29],"EAE.":[30,128],"In":[31],"this":[32,68],"study,":[33],"possible":[35],"role":[36,117],"endogenous":[38,119],"TGF-beta":[39,60,120],"regulation":[42],"relapsing":[44,127],"EAE":[45,104],"produced":[46],"transfer":[49],"myelin":[51],"basic":[52],"protein-specific":[53],"T":[54],"cell":[55],"lines":[56],"was":[57,70],"assessed.":[58],"Although":[59],"not":[62],"present":[63],"normal":[66],"CNS,":[67],"cytokine":[69],"detected":[71],"immunohistology":[73],"areas":[75],"both":[82],"acute":[83],"chronic":[85,126],"disease.":[86],"The":[87],"administration":[88],"anti-TGF-beta":[90],"at":[91],"onset":[94],"led":[95],"a":[97,116],"worsening":[98],"clinical":[101],"course":[102],"more":[106],"extensive":[107],"pathological":[108],"lesions.":[109],"These":[110],"findings":[111],"provide":[112],"direct":[113],"evidence":[114],"for":[115],"remissions":[123],"seen":[124]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
