{"id":"https://openalex.org/W1996709674","doi":"https://doi.org/10.1016/j.tox.2004.06.016","title":"The inhibition of LPS-induced splenocyte proliferation by ortho-substituted and microbially dechlorinated polychlorinated biphenyls is associated with a decreased expression of cyclin D2","display_name":"The inhibition of LPS-induced splenocyte proliferation by ortho-substituted and microbially dechlorinated polychlorinated biphenyls is associated with a decreased expression of cyclin D2","publication_year":2004,"publication_date":"2004-08-04","ids":{"openalex":"https://openalex.org/W1996709674","doi":"https://doi.org/10.1016/j.tox.2004.06.016","mag":"1996709674","pmid":"https://pubmed.ncbi.nlm.nih.gov/15369849"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2004.06.016","doi":"https://doi.org/10.1016/j.tox.2004.06.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2004.06.016","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090066039","display_name":"L. Ashley Smithwick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308126019","display_name":"National Oceanic and Atmospheric Administration","ror":"https://ror.org/02z5nhe81","country_code":"US","type":"government","lineage":["https://openalex.org/I1308126019","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210106306","display_name":"NCCOS Hollings Marine Laboratory","ror":"https://ror.org/01hp6xm80","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210106306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Ashley Smithwick","raw_affiliation_strings":["Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA","Center for Coastal and Environmental Health and Biomolecular Research and Hollings Marine Laboratory, U.S. National Oceanic and Atmospheric Administration, Charleston, SC 29412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Center for Coastal and Environmental Health and Biomolecular Research and Hollings Marine Laboratory, U.S. National Oceanic and Atmospheric Administration, Charleston, SC 29412, USA","institution_ids":["https://openalex.org/I1308126019","https://openalex.org/I4210106306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067672223","display_name":"John F. Quensen","orcid":"https://orcid.org/0000-0002-7669-1595","observed_orcids":["https://orcid.org/0000-0002-7669-1595"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Quensen","raw_affiliation_strings":["Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Smith","raw_affiliation_strings":["Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005461395","display_name":"David T. Kurtz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Kurtz","raw_affiliation_strings":["Department of Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104068370","display_name":"Lucille London","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucille London","raw_affiliation_strings":["Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA","Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108508730","display_name":"Pamela J. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308126019","display_name":"National Oceanic and Atmospheric Administration","ror":"https://ror.org/02z5nhe81","country_code":"US","type":"government","lineage":["https://openalex.org/I1308126019","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210106306","display_name":"NCCOS Hollings Marine Laboratory","ror":"https://ror.org/01hp6xm80","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210106306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pamela J. Morris","raw_affiliation_strings":["Center for Coastal and Environmental Health and Biomolecular Research and Hollings Marine Laboratory, U.S. National Oceanic and Atmospheric Administration, Charleston, SC 29412, USA","Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Coastal and Environmental Health and Biomolecular Research and Hollings Marine Laboratory, U.S. National Oceanic and Atmospheric Administration, Charleston, SC 29412, USA","institution_ids":["https://openalex.org/I1308126019","https://openalex.org/I4210106306"]},{"raw_affiliation_string":"Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, SC 29412, USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108508730"],"corresponding_institution_ids":["https://openalex.org/I1308126019","https://openalex.org/I153297377","https://openalex.org/I4210106306"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.2605,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58740018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"204","issue":"1","first_page":"61","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.3059000074863434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":1.0},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.8960000276565552},{"id":"https://openalex.org/keywords/aroclor-1242","display_name":"Aroclor 1242","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pcb-mixtures","display_name":"PCB mixtures","score":0.7509999871253967},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.9113271236419678},{"id":"https://openalex.org/C2779357283","wikidata":"https://www.wikidata.org/wiki/Q5160401","display_name":"Congener","level":2,"score":0.7680313587188721},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.6534565091133118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6496649980545044},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6339161396026611},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6255234479904175},{"id":"https://openalex.org/C2780733254","wikidata":"https://www.wikidata.org/wiki/Q5198271","display_name":"Cyclin D2","level":5,"score":0.5863741040229797},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5579668879508972},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.552398681640625},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.5190547108650208},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.446293443441391},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.41770100593566895},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33312052488327026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3305591940879822},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29533252120018005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2437155544757843},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21863910555839539},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15037453174591064},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.06847971677780151}],"mesh":[{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001140","descriptor_name":"Aroclors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056742","descriptor_name":"Cyclin D2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2004.06.016","doi":"https://doi.org/10.1016/j.tox.2004.06.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2004.06.016","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:15369849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15369849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W58212498","https://openalex.org/W95988660","https://openalex.org/W1589209214","https://openalex.org/W1931088714","https://openalex.org/W1962215380","https://openalex.org/W1966243944","https://openalex.org/W1985096197","https://openalex.org/W1992086828","https://openalex.org/W1992838377","https://openalex.org/W1993382029","https://openalex.org/W2000276669","https://openalex.org/W2005327717","https://openalex.org/W2011648754","https://openalex.org/W2017896421","https://openalex.org/W2022411432","https://openalex.org/W2022611597","https://openalex.org/W2045870726","https://openalex.org/W2047781891","https://openalex.org/W2051760822","https://openalex.org/W2054178406","https://openalex.org/W2055874995","https://openalex.org/W2058902282","https://openalex.org/W2060665524","https://openalex.org/W2061793769","https://openalex.org/W2065987209","https://openalex.org/W2070853191","https://openalex.org/W2078459735","https://openalex.org/W2083230754","https://openalex.org/W2088147248","https://openalex.org/W2094451152","https://openalex.org/W2098675621","https://openalex.org/W2100282248","https://openalex.org/W2101666778","https://openalex.org/W2118954198","https://openalex.org/W2120253175","https://openalex.org/W2122613732","https://openalex.org/W2128635872","https://openalex.org/W2130515692","https://openalex.org/W2132522883","https://openalex.org/W2142387974","https://openalex.org/W2145337751","https://openalex.org/W2148960967","https://openalex.org/W2153994151","https://openalex.org/W2158534538","https://openalex.org/W2158693362","https://openalex.org/W2296154126","https://openalex.org/W6640511658","https://openalex.org/W6697674179"],"related_works":["https://openalex.org/W2000276669","https://openalex.org/W2045870726","https://openalex.org/W2171751543","https://openalex.org/W4413048011","https://openalex.org/W1993382029","https://openalex.org/W4230271548","https://openalex.org/W1992086828","https://openalex.org/W2118954198","https://openalex.org/W2035347185","https://openalex.org/W2154121322"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
