{"id":"https://openalex.org/W1996702377","doi":"https://doi.org/10.1158/1538-7445.am2011-3415","title":"Abstract 3415: Diverse roles for Snail transcription factor in epithelial-mesenchymal transition (EMT) and neuroendocrine differentiation (NED) in human prostate cancer","display_name":"Abstract 3415: Diverse roles for Snail transcription factor in epithelial-mesenchymal transition (EMT) and neuroendocrine differentiation (NED) in human prostate cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1996702377","doi":"https://doi.org/10.1158/1538-7445.am2011-3415","mag":"1996702377"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-3415","doi":"https://doi.org/10.1158/1538-7445.am2011-3415","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3415","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081195057","display_name":"Danielle N. McKeithen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle McKeithen","raw_affiliation_strings":["1Clark Atlanta Univ., Atlanta, GA","1Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clark Atlanta Univ., Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]},{"raw_affiliation_string":"1Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111798426","display_name":"Tisheeka R. Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tisheeka Graham","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014047283","display_name":"Colm M. Morrissey","orcid":"https://orcid.org/0000-0003-1906-5333","observed_orcids":["https://orcid.org/0000-0003-1906-5333"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colm Morrissey","raw_affiliation_strings":["3University of Washington, Seattle, WA","#N#3University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"#N#3University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109082236","display_name":"Xiaotun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotun Zhang","raw_affiliation_strings":["3University of Washington, Seattle, WA","#N#3University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"#N#3University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010686592","display_name":"Leland W.K. Chung","orcid":"https://orcid.org/0000-0003-0072-6939","observed_orcids":["https://orcid.org/0000-0003-0072-6939","https://orcid.org/0000-0001-9445-3569"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leland W K Chung","raw_affiliation_strings":["4Cedars Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cedars Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038943566","display_name":"Valerie Odero-Marah","orcid":"https://orcid.org/0000-0002-5238-9914","observed_orcids":["https://orcid.org/0000-0002-5238-9914"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie Odero-Marah","raw_affiliation_strings":["1Clark Atlanta Univ., Atlanta, GA","1Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clark Atlanta Univ., Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]},{"raw_affiliation_string":"1Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"3415","last_page":"3415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snail-transcription-factor","display_name":"Snail transcription factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":1.0},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7080000042915344},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5540000200271606},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8579999804496765},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.930607795715332},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6503933072090149},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6255254745483398},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.5878368020057678},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5248365998268127},{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.5196653604507446},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.4749722182750702},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4735404849052429},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4676384925842285},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4506814181804657},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.44719645380973816},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4109797477722168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.362560510635376},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.26416850090026855},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2420995533466339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.223300963640213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15595528483390808},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15281397104263306},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.058015018701553345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-3415","doi":"https://doi.org/10.1158/1538-7445.am2011-3415","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3415","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969597507","https://openalex.org/W3111138770","https://openalex.org/W2174827731","https://openalex.org/W2043709265","https://openalex.org/W1601951722","https://openalex.org/W2332527080","https://openalex.org/W2917873722","https://openalex.org/W2009215637","https://openalex.org/W2773926164","https://openalex.org/W6981276643"],"abstract_inverted_index":{"Abstract":[0],"Snail":[1,49,98,140,186,197,219,228,258,275,313],"transcription":[2,276],"factor":[3,277],"induces":[4],"epithelial-mesenchymal":[5],"transition":[6],"(EMT)":[7],"via":[8],"decreased":[9],"cell":[10,43,92,200],"adhesion-associated":[11],"molecules":[12],"like":[13,19],"E-cadherin,":[14],"and":[15,37,76,84,106,161,192,205,224,265],"increased":[16,34,136,156,216],"mesenchymal":[17],"markers":[18,71],"vimentin.":[20],"We":[21,65,118],"previously":[22,127],"established":[23],"Snail-mediated":[24],"EMT":[25,292,321],"model":[26,134],"utilizing":[27],"androgen-dependent":[28],"LNCaP":[29,52,94,121,145,160,175,204],"cells.":[30,147,163,207],"These":[31],"cells":[32,53,56,95,123,155,169,176,286],"express":[33],"vimentin":[35],"protein":[36,141],"relocalization":[38],"of":[39,69,112,139,158,185,190,210,218,291,312,333,338],"E-cadherin":[40],"from":[41,151],"the":[42,46,102,116,152,283,334,339],"membrane":[44],"to":[45,88,115,144,247,296],"cytosol.":[47],"Interestingly,":[48],"transfection":[50],"in":[51,55,101,167,173,202,232,255,262,282,317],"resulted":[54],"acquiring":[57],"a":[58,130,238,306],"neuroendocrine-like":[59],"morphology":[60],"with":[61,97,187,194,220,250],"long":[62],"neurite-like":[63],"processes.":[64],"tested":[66],"for":[67,90,342],"expression":[68,137,217],"neuroendocrine":[70,103,239,252,264],"neuron":[72],"specific":[73],"enolase":[74],"(NSE)":[75],"chromogranin":[77],"A":[78],"(CgA)":[79],"by":[80,177,183,242,305],"Western":[81],"blot":[82],"analysis,":[83],"performed":[85],"proliferation":[86,157,201,304],"assays":[87],"test":[89],"paracrine":[91,199,307],"proliferation.":[93],"transfected":[96,154],"displayed":[99],"increase":[100],"markers,":[104],"NSE":[105,191],"CgA":[107,193,243],"as":[108,110,129,142,245],"well":[109],"translocation":[111],"androgen":[113],"receptor":[114],"nucleus.":[117],"found":[119],"that":[120,124,171,274],"C-33":[122],"have":[125],"been":[126],"published":[128],"Neuroendocrine":[131],"Differentiation":[132],"(NED)":[133],"exhibited":[135],"levels":[138],"compared":[143,246],"parental":[146,159,174,203],"Functionally,":[148],"conditioned":[149],"medium":[150],"LNCaP-Snail":[153],"PC-3":[162],"In":[164],"addition,":[165],"NED":[166,300],"LNCaP-C33":[168],"or":[170],"induced":[172,198],"serum":[178],"starvation":[179],"could":[180],"be":[181,294],"inhibited":[182],"knockdown":[184],"siRNA.":[188],"Knockdown":[189],"siRNA":[195],"abrogated":[196],"PC3":[206],"Immunohistochemical":[208],"staining":[209,229],"prostate":[211,221,234,284],"cancer":[212,222,235,249,267,285],"patient":[213],"tissue":[214,236],"revealed":[215],"progression":[223],"bone":[225],"metastasis.":[226],"Higher":[227],"was":[230,259],"observed":[231],"primary":[233,248],"containing":[237],"component":[240],"(identified":[241],"staining)":[244],"no":[251],"differentiation.":[253],"However,":[254],"metastatic":[256],"tissue,":[257],"highly":[260],"expressed":[261],"both":[263],"non-neuroendocrine":[266],"tissue.":[268],"Overall":[269],"our":[270],"data":[271],"provide":[272],"evidence":[273],"may":[278,293,301,314],"promote":[279,297,302],"tumor":[280,303],"aggressiveness":[281],"through":[287],"multiple":[288],"processes;":[289],"induction":[290],"required":[295],"migration,":[298],"while":[299],"mechanism.":[308],"Therefore,":[309],"therapeutic":[310],"targeting":[311],"prove":[315],"beneficial":[316],"not":[318],"only":[319],"abrogating":[320],"but":[322],"also":[323],"NED.":[324],"Citation":[325],"Format:":[326],"{Authors}.":[327],"{Abstract":[328],"title}":[329],"[abstract].":[330],"In:":[331],"Proceedings":[332],"102nd":[335],"Annual":[336],"Meeting":[337],"American":[340],"Association":[341],"Cancer":[343,353],"Research;":[344],"2011":[345],"Apr":[346],"2-6;":[347],"Orlando,":[348],"FL.":[349],"Philadelphia":[350],"(PA):":[351],"AACR;":[352],"Res":[354],"2011;71(8":[355],"Suppl):Abstract":[356],"nr":[357],"3415.":[358],"doi:10.1158/1538-7445.AM2011-3415":[359]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}