{"id":"https://openalex.org/W1996696087","doi":"https://doi.org/10.1001/archsurg.135.12.1432","title":"Signaling Mechanisms of Altered Cellular Responses in Trauma, Burn, and Sepsis","display_name":"Signaling Mechanisms of Altered Cellular Responses in Trauma, Burn, and Sepsis","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1996696087","doi":"https://doi.org/10.1001/archsurg.135.12.1432","mag":"1996696087","pmid":"https://pubmed.ncbi.nlm.nih.gov/11115349"},"language":"en","primary_location":{"id":"doi:10.1001/archsurg.135.12.1432","doi":"https://doi.org/10.1001/archsurg.135.12.1432","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archsurg.135.12.1432","pdf_url":null,"source":{"id":"https://openalex.org/S61251237","display_name":"Archives of Surgery","issn_l":"0004-0010","issn":["0004-0010","0272-5533","1538-3644","2376-3590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105366555","display_name":"Mohammed M. Sayeed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammed M. Sayeed","raw_affiliation_strings":["Department of Surgery, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA. msayeed@luc.edu","Department of Surgery, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL, 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA. msayeed@luc.edu","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Department of Surgery, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL, 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5105366555"],"corresponding_institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"],"apc_list":null,"apc_paid":null,"fwci":1.0704,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.76467827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"135","issue":"12","first_page":"1432","last_page":"1432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7950000166893005},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.972000002861023},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.8899999856948853},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.7699999809265137},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":1.0},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neutrophil-respiratory-burst","display_name":"neutrophil respiratory burst","score":0.7929999828338623},{"id":"https://openalex.org/keywords/t-cell-proliferation-inhibition","display_name":"T cell proliferation inhibition","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/inflammatory-immune-response","display_name":"inflammatory immune response","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6329557299613953},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6216673851013184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5725370049476624},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4786749482154846},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4325900077819824},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4215030074119568},{"id":"https://openalex.org/C2993242423","wikidata":"https://www.wikidata.org/wiki/Q170518","display_name":"Burn injury","level":2,"score":0.41831257939338684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41172632575035095},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38795140385627747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37973594665527344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30094075202941895},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0816589891910553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archsurg.135.12.1432","doi":"https://doi.org/10.1001/archsurg.135.12.1432","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archsurg.135.12.1432","pdf_url":null,"source":{"id":"https://openalex.org/S61251237","display_name":"Archives of Surgery","issn_l":"0004-0010","issn":["0004-0010","0272-5533","1538-3644","2376-3590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Surgery","raw_type":"journal-article"},{"id":"pmid:11115349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11115349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of surgery (Chicago, Ill. : 1960)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G178815319","display_name":null,"funder_award_id":"R0I-GM53235","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6346890856","display_name":null,"funder_award_id":"R0I-GM56865","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W20989522","https://openalex.org/W123777728","https://openalex.org/W128004132","https://openalex.org/W191708048","https://openalex.org/W1510633031","https://openalex.org/W1530792946","https://openalex.org/W1604872463","https://openalex.org/W1615014609","https://openalex.org/W1669690603","https://openalex.org/W1774645112","https://openalex.org/W1798736200","https://openalex.org/W1822094726","https://openalex.org/W1847283821","https://openalex.org/W1953990941","https://openalex.org/W1954023508","https://openalex.org/W1956266132","https://openalex.org/W1963880868","https://openalex.org/W1965021019","https://openalex.org/W1965759621","https://openalex.org/W1967282700","https://openalex.org/W1972359377","https://openalex.org/W1973924785","https://openalex.org/W1975066242","https://openalex.org/W1980166477","https://openalex.org/W1982005911","https://openalex.org/W1986233956","https://openalex.org/W1991623174","https://openalex.org/W1997524264","https://openalex.org/W2001266312","https://openalex.org/W2001758075","https://openalex.org/W2011395179","https://openalex.org/W2016452487","https://openalex.org/W2017100096","https://openalex.org/W2020413957","https://openalex.org/W2022563174","https://openalex.org/W2030014624","https://openalex.org/W2034369651","https://openalex.org/W2035644849","https://openalex.org/W2036219374","https://openalex.org/W2036443302","https://openalex.org/W2037756625","https://openalex.org/W2038198407","https://openalex.org/W2040518270","https://openalex.org/W2041152900","https://openalex.org/W2041726757","https://openalex.org/W2041999853","https://openalex.org/W2043806664","https://openalex.org/W2044951913","https://openalex.org/W2053037368","https://openalex.org/W2054225000","https://openalex.org/W2055030035","https://openalex.org/W2059496376","https://openalex.org/W2061756277","https://openalex.org/W2067810651","https://openalex.org/W2072972049","https://openalex.org/W2081867133","https://openalex.org/W2083063136","https://openalex.org/W2105896882","https://openalex.org/W2106086463","https://openalex.org/W2108373777","https://openalex.org/W2114809267","https://openalex.org/W2116570389","https://openalex.org/W2119370017","https://openalex.org/W2120194106","https://openalex.org/W2139871686","https://openalex.org/W2154746915","https://openalex.org/W2161089523","https://openalex.org/W2170257664","https://openalex.org/W2175518322","https://openalex.org/W2181792032","https://openalex.org/W2182141197","https://openalex.org/W2184127483","https://openalex.org/W2186291502","https://openalex.org/W2188318373","https://openalex.org/W2192751359","https://openalex.org/W2208581503","https://openalex.org/W2215223210","https://openalex.org/W2225546808","https://openalex.org/W2226437153","https://openalex.org/W2278289324","https://openalex.org/W2279705580","https://openalex.org/W2282085055","https://openalex.org/W2282221705","https://openalex.org/W2287605684","https://openalex.org/W2297940787","https://openalex.org/W2328876451","https://openalex.org/W2332534830","https://openalex.org/W2335815721","https://openalex.org/W2343267190","https://openalex.org/W2394653947","https://openalex.org/W2400854926","https://openalex.org/W2404157374","https://openalex.org/W2404517103","https://openalex.org/W2406528661","https://openalex.org/W2413106229","https://openalex.org/W2413298817","https://openalex.org/W2415497336","https://openalex.org/W2416022024","https://openalex.org/W2417325086","https://openalex.org/W2420619443","https://openalex.org/W2441441324","https://openalex.org/W2469497328","https://openalex.org/W2470607743"],"related_works":["https://openalex.org/W2416022024","https://openalex.org/W2082701559","https://openalex.org/W4238382390","https://openalex.org/W2417325086","https://openalex.org/W2397498931","https://openalex.org/W2077635591","https://openalex.org/W2059781055","https://openalex.org/W2037891177","https://openalex.org/W2165485590","https://openalex.org/W2003624364"],"abstract_inverted_index":{"Alterations":[0],"in":[1,4,20,41,56,65,77,122,159,175,192,209,227],"cellular":[2,225],"responses":[3,30,226],"various":[5],"organ":[6,15,230],"systems":[7],"contribute":[8],"to":[9,34,51,86,131,151,169,188,217],"trauma-,":[10],"burn-,":[11],"and":[12,25,27,59,84,95,164],"sepsis-related":[13],"multiple":[14],"dysfunction":[16,64],"syndrome.":[17],"Such":[18],"alterations":[19],"muscle":[21,62,81],"contractile,":[22],"hepatic":[23,93],"metabolic,":[24],"neutrophil":[26],"T-cell":[28,184],"inflammatory-immune":[29],"have":[31],"been":[32],"shown":[33],"result":[35,132],"from":[36,133],"cell-signaling":[37,207],"modulations":[38],"and/or":[39],"impairments":[40],"the":[42,57,66,138,160,193,223,228],"respective":[43],"cell":[44],"types.":[45],"Altered":[46],"Ca(2+)":[47,173,202],"signaling":[48,70,144,174,180],"would":[49,149],"seem":[50,150],"play":[52],"an":[53,134,153],"important":[54],"role":[55,76],"myocardial":[58],"vascular":[60],"smooth":[61],"contractile":[63],"injury":[67,147],"conditions;":[68],"Ca(2+)-linked":[69],"derangement":[71,181],"also":[72,100],"plays":[73],"a":[74,104,117,170,190],"crucial":[75,179],"sepsis-induced":[78],"altered":[79],"skeletal":[80,161],"protein":[82,97,196],"catabolism":[83],"resistance":[85],"insulin-mediated":[87],"glucose":[88],"use.":[89],"The":[90,111,146,178,204],"injury-related":[91],"increased":[92,112],"gluconeogenesis":[94],"acute-phase":[96],"response":[98,121],"could":[99],"be":[101,189],"caused":[102],"by":[103,115],"pathophysiologic":[105],"up-regulation":[106,135,155],"of":[107,136,156,172,195,206,219],"hepatocyte":[108],"Ca(2+)-signal":[109,157],"generation.":[110],"oxidant":[113],"production":[114],"neutrophil,":[116,165],"potentially":[118],"detrimental":[119],"inflammatory":[120],"early":[123],"stages":[124],"after":[125],"burn":[126],"or":[127,212],"septic":[128],"injuries,":[129],"seems":[130,187],"both":[137],"Ca(2+)-dependent":[139],"as":[140,142],"well":[141],"Ca(2+)-independent":[143],"pathways.":[145],"conditions":[148,214],"cause":[152],"inappropriate":[154],"generation":[158],"myocyte,":[162],"hepatocyte,":[163],"while":[166],"they":[167],"lead":[168,216],"down-regulation":[171],"T":[176],"cells.":[177],"that":[182],"causes":[183],"proliferation":[185],"suppression":[186],"decrease":[191],"activation":[194],"tyrosine":[197],"kinases,":[198],"which":[199],"subsequently":[200],"down-regulates":[201],"signaling.":[203],"delineation":[205],"derangements":[208],"trauma,":[210],"burn,":[211],"sepsis":[213],"can":[215],"development":[218],"therapeutic":[220],"interventions":[221],"against":[222],"disturbed":[224],"vital":[229],"systems.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
