{"id":"https://openalex.org/W1996672446","doi":"https://doi.org/10.2147/ijn.s58487","title":"Interaction of gelatin with polyenes modulates antifungal activity and biocompatibility of electrospun fiber mats","display_name":"Interaction of gelatin with polyenes modulates antifungal activity and biocompatibility of electrospun fiber mats","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1996672446","doi":"https://doi.org/10.2147/ijn.s58487","mag":"1996672446","pmid":"https://pubmed.ncbi.nlm.nih.gov/24920895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4043707"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s58487","doi":"https://doi.org/10.2147/ijn.s58487","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s58487","pdf_url":"https://www.dovepress.com/getfile.php?fileID=20217","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=20217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035157534","display_name":"Rajamani Lakshminarayanan","orcid":"https://orcid.org/0000-0001-8214-5315","observed_orcids":["https://orcid.org/0000-0001-8214-5315"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Rajamani Lakshminarayanan","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I4210116917","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036117183","display_name":"Radhakrishnan Sridhar","orcid":"https://orcid.org/0000-0002-5068-3175","observed_orcids":["https://orcid.org/0000-0002-5068-3175"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Radhakrishnan Sridhar","raw_affiliation_strings":["Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore","Center for Nanofibers and Nanotechnology, National University of Singapore,","Department of Mechanical Engineering, National University of Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Center for Nanofibers and Nanotechnology, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059594060","display_name":"Xian Jun Loh","orcid":"https://orcid.org/0000-0001-8118-6502","observed_orcids":["https://orcid.org/0000-0001-8118-6502"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210123095","display_name":"Institute of Materials Research and Engineering","ror":"https://ror.org/02sepg748","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210123095","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xian Jun Loh","raw_affiliation_strings":["Institute of Materials Research and Engineering, ASTAR (Agency for Science, Technology and Research), 3 Research Link, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materials Research and Engineering, ASTAR (Agency for Science, Technology and Research), 3 Research Link, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210123095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064163160","display_name":"Muruganantham Nandhakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Muruganantham Nandhakumar","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045929103","display_name":"Veluchamy A. Barathi","orcid":"https://orcid.org/0000-0002-6477-9784","observed_orcids":["https://orcid.org/0000-0002-6477-9784"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Veluchamy Amutha Barathi","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore ; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore,","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore ; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061933398","display_name":"Kalaipriya Madhaiyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Madhaiyan Kalaipriya","raw_affiliation_strings":["Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore","Center for Nanofibers and Nanotechnology, National University of Singapore,","Department of Mechanical Engineering, National University of Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Center for Nanofibers and Nanotechnology, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023054533","display_name":"Jia Lin Kwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jia Lin Kwan","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014496709","display_name":"Shou Ping Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shou Ping Liu","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I4210116917","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger Wilmer Beuerman","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","Singapore Eye Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore ; Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I4210116917","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Singapore Eye Research Institute,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034165453","display_name":"Seeram Ramakrishna","orcid":"https://orcid.org/0000-0001-8479-8686","observed_orcids":["https://orcid.org/0000-0001-8479-8686"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Seeram Ramakrishna","raw_affiliation_strings":["Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore ; NUS Nanoscience and Nanotechnology Initiative, Singapore","Center for Nanofibers and Nanotechnology, National University of Singapore,","Department of Mechanical Engineering, National University of Singapore,","NUS Nanoscience and Nanotechnology Initiative, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore, Singapore ; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore ; NUS Nanoscience and Nanotechnology Initiative, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Center for Nanofibers and Nanotechnology, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"NUS Nanoscience and Nanotechnology Initiative, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035157534"],"corresponding_institution_ids":["https://openalex.org/I4210116917","https://openalex.org/I4210126319"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":4.6694,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.96519238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"2439","last_page":"2439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11511","display_name":"Dyeing and Modifying Textile Fibers","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/polyene-antibiotics","display_name":"polyene antibiotics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/electrospun-fiber-mats","display_name":"electrospun mats","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antifungal-drug-delivery","display_name":"antifungal drug delivery","score":0.8610000014305115},{"id":"https://openalex.org/keywords/terbinafine","display_name":"terbinafine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9769999980926514},{"id":"https://openalex.org/keywords/natamycin","display_name":"natamycin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/filamentous-fungi","display_name":"filamentous fungi","score":0.6679999828338623},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/corneal-fibroblasts","display_name":"corneal fibroblasts","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/topical-antifungal-therapy","display_name":"topical antifungal therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/superficial-skin-infections","display_name":"superficial skin infections","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.8747354745864868},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.7635810375213623},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7564046382904053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6222006678581238},{"id":"https://openalex.org/C144796933","wikidata":"https://www.wikidata.org/wiki/Q1533542","display_name":"Electrospinning","level":3,"score":0.5855997204780579},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4301057457923889},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42459675669670105},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3933907151222229},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.32995694875717163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24877148866653442},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.18696171045303345},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15516245365142822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14555850625038147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11747777462005615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0803702175617218},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004595","descriptor_name":"Electroplating","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008567","descriptor_name":"Membranes, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012399","descriptor_name":"Rotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.2147/ijn.s58487","doi":"https://doi.org/10.2147/ijn.s58487","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s58487","pdf_url":"https://www.dovepress.com/getfile.php?fileID=20217","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4043707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4043707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:24920895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24920895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:tampub.uta.fi:10024/100109","doi":null,"is_oa":true,"landing_page_url":"http://tampub.uta.fi/handle/10024/100109","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"publishedVersion"},{"id":"pmh:oai:doaj.org/article:be3a9f87322248b7ba5a939e379eb494","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be3a9f87322248b7ba5a939e379eb494","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2439-2458 (2014)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/16884","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/interaction-of-gelatin-with-polyenes-modulates-antifungal-activity-and-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:trepo.tuni.fi:10024/100109","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/100109","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"}],"best_oa_location":{"id":"doi:10.2147/ijn.s58487","doi":"https://doi.org/10.2147/ijn.s58487","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s58487","pdf_url":"https://www.dovepress.com/getfile.php?fileID=20217","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996672446.pdf","grobid_xml":"https://content.openalex.org/works/W1996672446.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1964104586","https://openalex.org/W1967789669","https://openalex.org/W1969449166","https://openalex.org/W1969529086","https://openalex.org/W1974206701","https://openalex.org/W1980964205","https://openalex.org/W1984562540","https://openalex.org/W1986503147","https://openalex.org/W1988799094","https://openalex.org/W1991158714","https://openalex.org/W1999003507","https://openalex.org/W2002596833","https://openalex.org/W2002809107","https://openalex.org/W2003564377","https://openalex.org/W2003629764","https://openalex.org/W2007499283","https://openalex.org/W2008805549","https://openalex.org/W2011175537","https://openalex.org/W2014188602","https://openalex.org/W2016609595","https://openalex.org/W2045227360","https://openalex.org/W2048074482","https://openalex.org/W2051558930","https://openalex.org/W2052647448","https://openalex.org/W2053603737","https://openalex.org/W2055593282","https://openalex.org/W2056013343","https://openalex.org/W2066543594","https://openalex.org/W2073053027","https://openalex.org/W2073760577","https://openalex.org/W2075956036","https://openalex.org/W2082939222","https://openalex.org/W2083392617","https://openalex.org/W2084495529","https://openalex.org/W2090296204","https://openalex.org/W2090702750","https://openalex.org/W2107794472","https://openalex.org/W2112188937","https://openalex.org/W2112487751","https://openalex.org/W2115341132","https://openalex.org/W2121876863","https://openalex.org/W2129312417","https://openalex.org/W2129725688","https://openalex.org/W2134120449","https://openalex.org/W2137037625","https://openalex.org/W2141746397","https://openalex.org/W2142335027","https://openalex.org/W2145536375","https://openalex.org/W2148261517","https://openalex.org/W2156486682","https://openalex.org/W2157248428","https://openalex.org/W2158363156","https://openalex.org/W2163989602","https://openalex.org/W2323570170","https://openalex.org/W2327246950","https://openalex.org/W2424906403","https://openalex.org/W2575699064","https://openalex.org/W2787789903","https://openalex.org/W2949145884","https://openalex.org/W4246585686"],"related_works":["https://openalex.org/W4406327950","https://openalex.org/W3167825048","https://openalex.org/W4409994100","https://openalex.org/W2966634647","https://openalex.org/W7213769444","https://openalex.org/W2340941381","https://openalex.org/W2521404237","https://openalex.org/W4200297560","https://openalex.org/W2788453286","https://openalex.org/W7132578175"],"abstract_inverted_index":{"Topical":[0],"application":[1],"of":[2,30,57,73,112,148,153,159,176,181,183,197],"antifungals":[3,92,134],"does":[4],"not":[5],"have":[6],"predictable":[7],"or":[8],"well-controlled":[9],"release":[10],"characteristics":[11],"and":[12,35,44,67,75,126,135,150,171],"requires":[13],"reapplication":[14],"to":[15,167],"achieve":[16],"therapeutic":[17],"local":[18],"concentration":[19],"in":[20,60,64,194],"a":[21,61,139],"reasonable":[22],"time":[23],"period.":[24],"In":[25],"this":[26],"article,":[27],"the":[28,68,71,89,94,113,141,144,151,156,184,195],"efficacy":[29],"five":[31],"different":[32],"US":[33],"Food":[34],"Drug":[36],"Administration-approved":[37],"antifungal-loaded":[38,186],"(amphotericin":[39],"B,":[40],"natamycin,":[41],"terbinafine,":[42],"fluconazole,":[43],"itraconazole)":[45],"electrospun":[46],"gelatin":[47,136,149,154,187],"fiber":[48,65,163,188],"mats":[49,69,80,109,118,164,189],"were":[50,81,165],"compared.":[51],"Morphological":[52],"studies":[53],"show":[54],"that":[55],"incorporation":[56],"polyenes":[58,142],"resulted":[59],"two-fold":[62],"increase":[63],"diameter":[66],"inhibit":[70],"growth":[72],"yeasts":[74],"filamentous":[76,85],"fungal":[77,86],"pathogens.":[78],"Terbinafine-loaded":[79],"effective":[82],"against":[83,99,110],"three":[84],"species.":[87],"Among":[88],"two":[90],"azole":[91],"compared,":[93],"itraconazole-loaded":[95],"mat":[96],"was":[97,105],"potent":[98],"Aspergillus":[100],"strains.":[101],"However,":[102],"activity":[103,158,182],"loss":[104],"observed":[106],"for":[107],"fluconazole-loaded":[108],"all":[111],"test":[114],"organisms.":[115],"The":[116,161,174],"polyene-loaded":[117,162],"displayed":[119],"rapid":[120],"candidacidal":[121],"activities":[122],"as":[123],"well.":[124],"Biophysical":[125],"rheological":[127],"measurements":[128],"indicate":[129],"strong":[130],"interactions":[131],"between":[132],"polyene":[133,185],"matrix.":[137],"As":[138],"result,":[140],"stabilized":[143],"triple":[145],"helical":[146],"conformation":[147],"presence":[152],"decreased":[155],"hemolytic":[157],"polyenes.":[160],"noncytotoxic":[166],"primary":[168],"human":[169],"corneal":[170],"sclera":[172],"fibroblasts.":[173],"reduction":[175],"toxicity":[177],"with":[178],"complete":[179],"retention":[180],"can":[190],"provide":[191],"new":[192],"opportunities":[193],"management":[196],"superficial":[198],"skin":[199],"infections.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
